CCR6 — 35 ClinVar variants
All ClinVar germline CCR6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 28 flagged for review →
1 Benign · 1 Benign/Likely benign · 6 Likely benign · 27 Uncertain significance
Full CCR6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 28
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 17
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCR6 p.Ala110Val Uncertain significance Single submitter
- CCR6 p.Ala265Thr Uncertain significance Single submitter
- CCR6 p.Ala265Val Uncertain significance Single submitter
- CCR6 p.Ala364Thr Uncertain significance Single submitter
- CCR6 p.Gln39Arg Uncertain significance Single submitter
- CCR6 p.Gly216Arg Uncertain significance Single submitter
- CCR6 p.Gly3Arg Uncertain significance Single submitter
- CCR6 p.Ile208Val Uncertain significance Single submitter
- CCR6 p.Leu34Ser Uncertain significance Single submitter
- CCR6 p.Leu94Phe Uncertain significance Single submitter
- CCR6 p.Lys283Glu Uncertain significance Single submitter
- CCR6 p.Met284Thr Uncertain significance Single submitter
- CCR6 p.Met374Val Uncertain significance Single submitter
- CCR6 p.Phe236Leu Uncertain significance Single submitter
- CCR6 p.Phe346Leu Uncertain significance Single submitter
- CCR6 p.Pro162Ser Uncertain significance Single submitter
- CCR6 p.Pro50Leu Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- CCR6 p.Arg157Gln Uncertain significance Single submitter
- CCR6 p.Arg163Ser Uncertain significance Single submitter
- CCR6 p.Glu40Lys Uncertain significance Single submitter
- CCR6 p.Leu331Trp Uncertain significance Single submitter
- CCR6 p.Lys251Glu Uncertain significance Single submitter
- CCR6 p.Met230Ile Uncertain significance Single submitter
- CCR6 p.Ser158Tyr Likely benign Single submitter
- CCR6 p.Ser45Phe Uncertain significance Single submitter
- CCR6 p.Val273Phe Uncertain significance Single submitter
- CCR6 p.Val68Met Uncertain significance Single submitter
- CCR6 p.Val83Phe Uncertain significance Single submitter
All CCR6 variants
Benign 1
- p.Arg159= Multiple submitters
Benign/Likely benign 1
- p.Ala369Val Multiple submitters
Likely benign 6
- p.Arg163His Single submitter
- p.Gly350Arg Single submitter
- p.Pro50= Single submitter
- p.Ser158Tyr Single submitter ⚠
- p.Ser194Arg Single submitter
- p.Thr117Met Single submitter
Uncertain significance 27
- p.Ala110Val Single submitter ⚠
- p.Ala265Thr Single submitter ⚠
- p.Ala265Val Single submitter ⚠
- p.Ala364Thr Single submitter ⚠
- p.Arg157Gln Single submitter ⚠
- p.Arg163Ser Single submitter ⚠
- p.Gln39Arg Single submitter ⚠
- p.Glu40Lys Single submitter ⚠
- p.Gly216Arg Single submitter ⚠
- p.Gly3Arg Single submitter ⚠
- p.Ile208Val Single submitter ⚠
- p.Leu331Trp Single submitter ⚠
- p.Leu34Ser Single submitter ⚠
- p.Leu94Phe Single submitter ⚠
- p.Lys251Glu Single submitter ⚠
- p.Lys283Glu Single submitter ⚠
- p.Met230Ile Single submitter ⚠
- p.Met284Thr Single submitter ⚠
- p.Met374Val Single submitter ⚠
- p.Phe236Leu Single submitter ⚠
- p.Phe346Leu Single submitter ⚠
- p.Pro162Ser Single submitter ⚠
- p.Pro50Leu Single submitter ⚠
- p.Ser45Phe Single submitter ⚠
- p.Val273Phe Single submitter ⚠
- p.Val68Met Single submitter ⚠
- p.Val83Phe Single submitter ⚠