CCR7 — 34 ClinVar variants
All ClinVar germline CCR7 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 31 flagged for review →
1 Benign · 2 Likely benign · 31 Uncertain significance
Full CCR7 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 31
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 16
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCR7 p.Ala261Ser Uncertain significance Single submitter
- CCR7 p.Ala327Thr Uncertain significance Single submitter
- CCR7 p.Ala58Gly Uncertain significance Single submitter
- CCR7 p.Arg363His Uncertain significance Single submitter
- CCR7 p.Gln224His Uncertain significance Single submitter
- CCR7 p.Ile150Thr Uncertain significance Single submitter
- CCR7 p.Ile273Val Uncertain significance Single submitter
- CCR7 p.Leu194Ile Uncertain significance Single submitter
- CCR7 p.Leu352Phe Uncertain significance Single submitter
- CCR7 p.Leu43Phe Uncertain significance Single submitter
- CCR7 p.Lys339Arg Uncertain significance Single submitter
- CCR7 p.Met366Val Uncertain significance Single submitter
- CCR7 p.Met64Val Uncertain significance Single submitter
- CCR7 p.Ser296Thr Uncertain significance Single submitter
- CCR7 p.Thr93Asn Uncertain significance Single submitter
- CCR7 p.Trp355Arg Uncertain significance Single submitter
Predictors split 15
The independent predictors disagree with each other — read with care.
- CCR7 p.Ala307Thr Uncertain significance Single submitter
- CCR7 p.Arg170His Uncertain significance Single submitter
- CCR7 p.Arg248Leu Uncertain significance Single submitter
- CCR7 p.Arg318His Uncertain significance Single submitter
- CCR7 p.Arg362Trp Uncertain significance Single submitter
- CCR7 p.Asn259Lys Uncertain significance Single submitter
- CCR7 p.Gln227Glu Uncertain significance Single submitter
- CCR7 p.Ile132Thr Uncertain significance Single submitter
- CCR7 p.Leu16Phe Uncertain significance Single submitter
- CCR7 p.Met144Leu Uncertain significance Single submitter
- CCR7 p.Phe241Ser Uncertain significance Single submitter
- CCR7 p.Ser295Arg Uncertain significance Single submitter
- CCR7 p.Ser9Asn Uncertain significance Single submitter
- CCR7 p.Thr311Ser Uncertain significance Single submitter
- CCR7 p.Val80Met Uncertain significance Single submitter
All CCR7 variants
Benign 1
- p.Arg154= Multiple submitters
Likely benign 2
- p.Arg201Lys Single submitter
- p.Val310Ile Single submitter
Uncertain significance 31
- p.Ala261Ser Single submitter ⚠
- p.Ala307Thr Single submitter ⚠
- p.Ala327Thr Single submitter ⚠
- p.Ala58Gly Single submitter ⚠
- p.Arg170His Single submitter ⚠
- p.Arg248Leu Single submitter ⚠
- p.Arg318His Single submitter ⚠
- p.Arg362Trp Single submitter ⚠
- p.Arg363His Single submitter ⚠
- p.Asn259Lys Single submitter ⚠
- p.Gln224His Single submitter ⚠
- p.Gln227Glu Single submitter ⚠
- p.Ile132Thr Single submitter ⚠
- p.Ile150Thr Single submitter ⚠
- p.Ile273Val Single submitter ⚠
- p.Leu16Phe Single submitter ⚠
- p.Leu194Ile Single submitter ⚠
- p.Leu352Phe Single submitter ⚠
- p.Leu43Phe Single submitter ⚠
- p.Lys339Arg Single submitter ⚠
- p.Met144Leu Single submitter ⚠
- p.Met366Val Single submitter ⚠
- p.Met64Val Single submitter ⚠
- p.Phe241Ser Single submitter ⚠
- p.Ser295Arg Single submitter ⚠
- p.Ser296Thr Single submitter ⚠
- p.Ser9Asn Single submitter ⚠
- p.Thr311Ser Single submitter ⚠
- p.Thr93Asn Single submitter ⚠
- p.Trp355Arg Single submitter ⚠
- p.Val80Met Single submitter ⚠