CCR9 — 53 ClinVar variants
All ClinVar germline CCR9 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 50 flagged for review →
1 Conflicting · 2 Benign · 1 Likely benign · 49 Uncertain significance
Full CCR9 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 50
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors agree, ClinVar conflicts 1
ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.
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CCR9 p.Ala14Ser
Conflicting
Single submitter
Bardet-Biedl syndrome 17
Predictors lean, ClinVar uncertain 29
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCR9 p.Arg325Leu Uncertain significance Single submitter
- CCR9 p.Asp16Asn Uncertain significance Single submitter
- CCR9 p.Asp16Glu Uncertain significance Single submitter
- CCR9 p.Asp205Asn Uncertain significance Single submitter
- CCR9 p.Asp84Asn Uncertain significance Single submitter
- CCR9 p.Gln111Lys Uncertain significance Single submitter
- CCR9 p.Gln342Arg Uncertain significance Single submitter
- CCR9 p.Glu206Asp Uncertain significance Single submitter
- CCR9 p.Ile236Val Uncertain significance Single submitter
- CCR9 p.Ile60Leu Uncertain significance Single submitter
- CCR9 p.Leu163Phe Uncertain significance Single submitter
- CCR9 p.Leu210Met Uncertain significance Single submitter
- CCR9 p.Leu210Pro Uncertain significance Single submitter
- CCR9 p.Leu210Val Uncertain significance Single submitter
- CCR9 p.Leu265Val Uncertain significance Single submitter
- CCR9 p.Met13Thr Uncertain significance Single submitter
- CCR9 p.Met13Val Uncertain significance Single submitter
- CCR9 p.Met152Thr Uncertain significance Single submitter
- CCR9 p.Met200Val Uncertain significance Single submitter
- CCR9 p.Met25Thr Uncertain significance Single submitter
- CCR9 p.Met85Thr Uncertain significance Single submitter
- CCR9 p.Phe114Ile Uncertain significance Single submitter
- CCR9 p.Phe114Leu Uncertain significance Single submitter
- CCR9 p.Phe86Leu Uncertain significance Single submitter
- CCR9 p.Pro52Ser Uncertain significance Single submitter
- CCR9 p.Thr235Ala Uncertain significance Single submitter
- CCR9 p.Trp343Ser Uncertain significance Single submitter
- CCR9 p.Val259Ile Uncertain significance Single submitter
- CCR9 p.Val29Ile Uncertain significance Single submitter
Predictors split 20
The independent predictors disagree with each other — read with care.
- CCR9 p.Cys311Ser Uncertain significance Single submitter
- CCR9 p.Gly194Ser Uncertain significance Single submitter
- CCR9 p.Gly336Asp Uncertain significance Single submitter
- CCR9 p.Ile242Thr Uncertain significance Single submitter
- CCR9 p.Leu163Trp Uncertain significance Single submitter
- CCR9 p.Leu175Ser Uncertain significance Single submitter
- CCR9 p.Leu64Ser Uncertain significance Single submitter
- CCR9 p.Leu96Ile Uncertain significance Single submitter
- CCR9 p.Lys254Asn Uncertain significance Single submitter
- CCR9 p.Phe346Leu Uncertain significance Single submitter
- CCR9 p.Ser187Gly Uncertain significance Single submitter
- CCR9 p.Ser339Asn Uncertain significance Single submitter
- CCR9 p.Ser8Arg Uncertain significance Single submitter
- CCR9 p.Thr278Ile Uncertain significance Single submitter
- CCR9 p.Thr304Ile Uncertain significance Single submitter
- CCR9 p.Thr7Lys Uncertain significance Single submitter
- CCR9 p.Trp343Gly Uncertain significance Single submitter
- CCR9 p.Val262Ile Uncertain significance Single submitter
- CCR9 p.Val43Ile Uncertain significance Single submitter
- CCR9 p.Val58Met Uncertain significance Single submitter
All CCR9 variants
Conflicting classifications of pathogenicity 1
- p.Ala14Ser Single submitter Bardet-Biedl syndrome 17 ⚠
Benign 2
- p.Leu136= Multiple submitters
- p.Ile92Val Single submitter
Likely benign 1
- p.Ala231Thr Single submitter
Uncertain significance 49
- p.Arg325Leu Single submitter ⚠
- p.Asp16Asn Single submitter ⚠
- p.Asp16Glu Single submitter ⚠
- p.Asp205Asn Single submitter ⚠
- p.Asp84Asn Single submitter ⚠
- p.Cys311Ser Single submitter ⚠
- p.Gln111Lys Single submitter ⚠
- p.Gln342Arg Single submitter ⚠
- p.Glu206Asp Single submitter ⚠
- p.Gly194Ser Single submitter ⚠
- p.Gly336Asp Single submitter ⚠
- p.Ile236Val Single submitter ⚠
- p.Ile242Thr Single submitter ⚠
- p.Ile60Leu Single submitter ⚠
- p.Leu163Phe Single submitter ⚠
- p.Leu163Trp Single submitter ⚠
- p.Leu175Ser Single submitter ⚠
- p.Leu210Met Single submitter ⚠
- p.Leu210Pro Single submitter ⚠
- p.Leu210Val Single submitter ⚠
- p.Leu265Val Single submitter ⚠
- p.Leu64Ser Single submitter ⚠
- p.Leu96Ile Single submitter ⚠
- p.Lys254Asn Single submitter ⚠
- p.Met13Thr Single submitter ⚠
- p.Met13Val Single submitter ⚠
- p.Met152Thr Single submitter ⚠
- p.Met200Val Single submitter ⚠
- p.Met25Thr Single submitter ⚠
- p.Met85Thr Single submitter ⚠
- p.Phe114Ile Single submitter ⚠
- p.Phe114Leu Single submitter ⚠
- p.Phe346Leu Single submitter ⚠
- p.Phe86Leu Single submitter ⚠
- p.Pro52Ser Single submitter ⚠
- p.Ser187Gly Single submitter ⚠
- p.Ser339Asn Single submitter ⚠
- p.Ser8Arg Single submitter ⚠
- p.Thr235Ala Single submitter ⚠
- p.Thr278Ile Single submitter ⚠
- p.Thr304Ile Single submitter ⚠
- p.Thr7Lys Single submitter ⚠
- p.Trp343Gly Single submitter ⚠
- p.Trp343Ser Single submitter ⚠
- p.Val259Ile Single submitter ⚠
- p.Val262Ile Single submitter ⚠
- p.Val29Ile Single submitter ⚠
- p.Val43Ile Single submitter ⚠
- p.Val58Met Single submitter ⚠