CCT4 — 78 ClinVar variants
All ClinVar germline CCT4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 75 flagged for review →
1 Benign · 1 Likely benign · 76 Uncertain significance
Full CCT4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 75
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 43
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCT4 p.Ala113Val Uncertain significance Single submitter
- CCT4 p.Ala308Val Uncertain significance Single submitter
- CCT4 p.Arg441Pro Uncertain significance Single submitter
- CCT4 p.Arg483Gly Uncertain significance Single submitter
- CCT4 p.Arg539Gln Uncertain significance Single submitter
- CCT4 p.Arg8Gln Uncertain significance Single submitter
- CCT4 p.Asn172Asp Uncertain significance Single submitter
- CCT4 p.Asn318Ser Uncertain significance Single submitter
- CCT4 p.Asn37Ser Uncertain significance Single submitter
- CCT4 p.Asp268Gly Uncertain significance Single submitter
- CCT4 p.Asp273Glu Uncertain significance Single submitter
- CCT4 p.Asp307Val Uncertain significance Single submitter
- CCT4 p.Asp63Tyr Uncertain significance Single submitter
- CCT4 p.Cys252Trp Uncertain significance Single submitter
- CCT4 p.Gln271Arg Uncertain significance Single submitter
- CCT4 p.Gln301His Uncertain significance Single submitter
- CCT4 p.Gln350His Uncertain significance Single submitter
- CCT4 p.Gly294Arg Uncertain significance Single submitter
- CCT4 p.His129Arg Uncertain significance Single submitter
- CCT4 p.His315Arg Uncertain significance Single submitter
- CCT4 p.His484Pro Uncertain significance Single submitter
- CCT4 p.Ile132Val Uncertain significance Single submitter
- CCT4 p.Ile145Val Uncertain significance Single submitter
- CCT4 p.Ile208Thr Uncertain significance Single submitter
- CCT4 p.Ile249Thr Uncertain significance Single submitter
- CCT4 p.Ile328Thr Uncertain significance Single submitter
- CCT4 p.Ile388Thr Uncertain significance Single submitter
- CCT4 p.Ile412Val Uncertain significance Single submitter
- CCT4 p.Ile48Val Uncertain significance Single submitter
- CCT4 p.Ile77Val Uncertain significance Single submitter
- CCT4 p.Leu148Phe Uncertain significance Single submitter
- CCT4 p.Leu148Trp Uncertain significance Single submitter
- CCT4 p.Lys59Glu Uncertain significance Single submitter
- CCT4 p.Met323Ile Uncertain significance Single submitter
- CCT4 p.Phe251Leu Uncertain significance Single submitter
- CCT4 p.Pro511Ser Uncertain significance Single submitter
- CCT4 p.Ser202Asn Uncertain significance Single submitter
- CCT4 p.Tyr24Phe Uncertain significance Single submitter
- CCT4 p.Tyr282Asp Uncertain significance Single submitter
- CCT4 p.Val211Ile Uncertain significance Single submitter
- CCT4 p.Val266Ile Uncertain significance Single submitter
- CCT4 p.Val516Leu Uncertain significance Single submitter
-
CCT4 p.Leu298Phe
Uncertain significance
No assertion criteria
CCT4-related disorder
Predictors split 32
The independent predictors disagree with each other — read with care.
- CCT4 p.Ala113Gly Uncertain significance Single submitter
- CCT4 p.Ala408Ser Uncertain significance Single submitter
- CCT4 p.Ala41Thr Uncertain significance Single submitter
- CCT4 p.Ala518Ser Uncertain significance Single submitter
- CCT4 p.Arg274Gln Uncertain significance Single submitter
- CCT4 p.Arg452His Uncertain significance Single submitter
- CCT4 p.Arg483Gln Uncertain significance Single submitter
- CCT4 p.Arg496Gln Uncertain significance Single submitter
- CCT4 p.Asp118Gly Uncertain significance Single submitter
- CCT4 p.Asp196His Uncertain significance Single submitter
- CCT4 p.Asp28Gly Uncertain significance Single submitter
- CCT4 p.Glu364Asp Uncertain significance Single submitter
- CCT4 p.Glu438Gly Uncertain significance Single submitter
- CCT4 p.Gly20Glu Uncertain significance Single submitter
- CCT4 p.Gly357Ala Uncertain significance Single submitter
- CCT4 p.Ile100Thr Uncertain significance Single submitter
- CCT4 p.Ile33Met Uncertain significance Single submitter
- CCT4 p.Ile340Met Uncertain significance Single submitter
- CCT4 p.Ile412Thr Uncertain significance Single submitter
- CCT4 p.Leu116Phe Uncertain significance Single submitter
- CCT4 p.Leu223Phe Uncertain significance Single submitter
- CCT4 p.Lys143Arg Uncertain significance Single submitter
- CCT4 p.Met186Val Uncertain significance Single submitter
- CCT4 p.Met458Val Uncertain significance Single submitter
- CCT4 p.Pro154Ser Uncertain significance Single submitter
- CCT4 p.Pro197Gln Uncertain significance Single submitter
- CCT4 p.Ser202Gly Uncertain significance Single submitter
- CCT4 p.Thr131Ala Uncertain significance Single submitter
- CCT4 p.Thr162Ile Uncertain significance Single submitter
- CCT4 p.Thr239Ile Uncertain significance Single submitter
- CCT4 p.Thr342Asn Uncertain significance Single submitter
- CCT4 p.Val224Met Uncertain significance Single submitter
All CCT4 variants
Benign 1
- c.128-17_128-16dup Single submitter
Likely benign 1
- p.Gly22Ser Single submitter
Uncertain significance 76
- p.Ala113Gly Single submitter ⚠
- p.Ala113Val Single submitter ⚠
- p.Ala308Val Single submitter ⚠
- p.Ala408Ser Single submitter ⚠
- p.Ala41Thr Single submitter ⚠
- p.Ala518Ser Single submitter ⚠
- p.Arg274Gln Single submitter ⚠
- p.Arg441Pro Single submitter ⚠
- p.Arg452His Single submitter ⚠
- p.Arg483Gln Single submitter ⚠
- p.Arg483Gly Single submitter ⚠
- p.Arg496Gln Single submitter ⚠
- p.Arg539Gln Single submitter ⚠
- p.Arg8Gln Single submitter ⚠
- p.Asn172Asp Single submitter ⚠
- p.Asn318Ser Single submitter ⚠
- p.Asn37Ser Single submitter ⚠
- p.Asp118Gly Single submitter ⚠
- p.Asp196His Single submitter ⚠
- p.Asp268Gly Single submitter ⚠
- p.Asp273Glu Single submitter ⚠
- p.Asp28Gly Single submitter ⚠
- p.Asp307Val Single submitter ⚠
- p.Asp63Tyr Single submitter ⚠
- p.Cys252Trp Single submitter ⚠
- p.Gln271Arg Single submitter ⚠
- p.Gln301His Single submitter ⚠
- p.Gln350His Single submitter ⚠
- p.Glu364Asp Single submitter ⚠
- p.Glu438Gly Single submitter ⚠
- p.Gly20Glu Single submitter ⚠
- p.Gly294Arg Single submitter ⚠
- p.Gly357Ala Single submitter ⚠
- p.His129Arg Single submitter ⚠
- p.His315Arg Single submitter ⚠
- p.His484Pro Single submitter ⚠
- p.Ile100Thr Single submitter ⚠
- p.Ile112del Single submitter
- p.Ile132Val Single submitter ⚠
- p.Ile145Val Single submitter ⚠
- p.Ile208Thr Single submitter ⚠
- p.Ile249Thr Single submitter ⚠
- p.Ile328Thr Single submitter ⚠
- p.Ile33Met Single submitter ⚠
- p.Ile340Met Single submitter ⚠
- p.Ile388Thr Single submitter ⚠
- p.Ile412Thr Single submitter ⚠
- p.Ile412Val Single submitter ⚠
- p.Ile48Val Single submitter ⚠
- p.Ile77Val Single submitter ⚠
- p.Leu116Phe Single submitter ⚠
- p.Leu148Phe Single submitter ⚠
- p.Leu148Trp Single submitter ⚠
- p.Leu223Phe Single submitter ⚠
- p.Lys143Arg Single submitter ⚠
- p.Lys59Glu Single submitter ⚠
- p.Met186Val Single submitter ⚠
- p.Met323Ile Single submitter ⚠
- p.Met458Val Single submitter ⚠
- p.Phe251Leu Single submitter ⚠
- p.Pro154Ser Single submitter ⚠
- p.Pro197Gln Single submitter ⚠
- p.Pro511Ser Single submitter ⚠
- p.Ser202Asn Single submitter ⚠
- p.Ser202Gly Single submitter ⚠
- p.Thr131Ala Single submitter ⚠
- p.Thr162Ile Single submitter ⚠
- p.Thr239Ile Single submitter ⚠
- p.Thr342Asn Single submitter ⚠
- p.Tyr24Phe Single submitter ⚠
- p.Tyr282Asp Single submitter ⚠
- p.Val211Ile Single submitter ⚠
- p.Val224Met Single submitter ⚠
- p.Val266Ile Single submitter ⚠
- p.Val516Leu Single submitter ⚠
- p.Leu298Phe No assertion criteria CCT4-related disorder ⚠