CCT6A — 53 ClinVar variants
All ClinVar germline CCT6A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 43 flagged for review →
1 Benign · 1 Likely benign · 51 Uncertain significance
Full CCT6A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 43
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 29
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCT6A p.Ala14Val Uncertain significance Single submitter
- CCT6A p.Ala2Pro Uncertain significance Single submitter
- CCT6A p.Ala452Val Uncertain significance Single submitter
- CCT6A p.Ala468Gly Uncertain significance Single submitter
- CCT6A p.Ala489Thr Uncertain significance Single submitter
- CCT6A p.Ala74Thr Uncertain significance Single submitter
- CCT6A p.Ala83Val Uncertain significance Single submitter
- CCT6A p.Arg217Gln Uncertain significance Single submitter
- CCT6A p.Arg279Gly Uncertain significance Single submitter
- CCT6A p.Arg523Gln Uncertain significance Single submitter
- CCT6A p.Asn482Ser Uncertain significance Single submitter
- CCT6A p.Gln182Arg Uncertain significance Single submitter
- CCT6A p.Glu136Lys Uncertain significance Single submitter
- CCT6A p.Glu352Asp Uncertain significance Single submitter
- CCT6A p.Ile149Lys Uncertain significance Single submitter
- CCT6A p.Ile274Val Uncertain significance Single submitter
- CCT6A p.Ile98Met Uncertain significance Single submitter
- CCT6A p.Leu206Phe Uncertain significance Single submitter
- CCT6A p.Leu384Val Uncertain significance Single submitter
- CCT6A p.Lys55Arg Uncertain significance Single submitter
- CCT6A p.Met487Thr Uncertain significance Single submitter
- CCT6A p.Met487Val Uncertain significance Single submitter
- CCT6A p.Pro427Arg Uncertain significance Single submitter
- CCT6A p.Ser111Phe Uncertain significance Single submitter
- CCT6A p.Ser175Ala Uncertain significance Single submitter
- CCT6A p.Ser205Arg Uncertain significance Single submitter
- CCT6A p.Thr82Ala Uncertain significance Single submitter
- CCT6A p.Val13Met Uncertain significance Single submitter
- CCT6A p.Val391Met Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- CCT6A p.Ala401Gly Uncertain significance Single submitter
- CCT6A p.Ala452Ser Uncertain significance Single submitter
- CCT6A p.Asp86Ala Uncertain significance Single submitter
- CCT6A p.Glu276Gln Uncertain significance Single submitter
- CCT6A p.Gly247Ala Uncertain significance Single submitter
- CCT6A p.Gly431Ser Uncertain significance Single submitter
- CCT6A p.His161Asp Uncertain significance Single submitter
- CCT6A p.Phe266Tyr Uncertain significance Single submitter
- CCT6A p.Ser155Cys Uncertain significance Single submitter
- CCT6A p.Thr57Ser Uncertain significance Single submitter
- CCT6A p.Tyr229His Uncertain significance Single submitter
- CCT6A p.Tyr353Cys Uncertain significance Single submitter
- CCT6A p.Val225Leu Uncertain significance Single submitter
- CCT6A p.Val271Phe Uncertain significance Single submitter
All CCT6A variants
Benign 1
- p.Ser473= Multiple submitters
Likely benign 1
- p.Phe336Leu Single submitter
Uncertain significance 51
- c.1450+1G>A Single submitter
- p.Ala14Val Single submitter ⚠
- p.Ala253Val Single submitter
- p.Ala2Pro Single submitter ⚠
- p.Ala401Gly Single submitter ⚠
- p.Ala452Ser Single submitter ⚠
- p.Ala452Val Single submitter ⚠
- p.Ala468Gly Single submitter ⚠
- p.Ala489Thr Single submitter ⚠
- p.Ala74Thr Single submitter ⚠
- p.Ala83Val Single submitter ⚠
- p.Arg217Gln Single submitter ⚠
- p.Arg279Gly Single submitter ⚠
- p.Arg523Gln Single submitter ⚠
- p.Asn482Ser Single submitter ⚠
- p.Asp86Ala Single submitter ⚠
- p.Gln182Arg Single submitter ⚠
- p.Glu136Lys Single submitter ⚠
- p.Glu276Gln Single submitter ⚠
- p.Glu352Asp Single submitter ⚠
- p.Gly247Ala Single submitter ⚠
- p.Gly431Ser Single submitter ⚠
- p.His161Asp Single submitter ⚠
- p.Ile149Lys Single submitter ⚠
- p.Ile274Val Single submitter ⚠
- p.Ile98Met Single submitter ⚠
- p.Leu206Phe Single submitter ⚠
- p.Leu384Val Single submitter ⚠
- p.Leu504Phe Single submitter
- p.Lys222Asn Single submitter
- p.Lys273Asn Single submitter
- p.Lys55Arg Single submitter ⚠
- p.Met487Thr Single submitter ⚠
- p.Met487Val Single submitter ⚠
- p.Phe266Tyr Single submitter ⚠
- p.Pro427Arg Single submitter ⚠
- p.Pro486Thr Single submitter
- p.Ser111Phe Single submitter ⚠
- p.Ser155Cys Single submitter ⚠
- p.Ser175Ala Single submitter ⚠
- p.Ser205Arg Single submitter ⚠
- p.Thr232Ser Single submitter
- p.Thr57Ser Single submitter ⚠
- p.Thr82Ala Single submitter ⚠
- p.Tyr229His Single submitter ⚠
- p.Tyr250fs Single submitter CCT6A-associated neurodevelopmental disorder
- p.Tyr353Cys Single submitter ⚠
- p.Val13Met Single submitter ⚠
- p.Val225Leu Single submitter ⚠
- p.Val271Phe Single submitter ⚠
- p.Val391Met Single submitter ⚠