CCT7 — 56 ClinVar variants
All ClinVar germline CCT7 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 56 flagged for review →
1 Pathogenic · 55 Uncertain significance
Full CCT7 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 56
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors vs ClinVar 1
ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.
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CCT7 p.Ser525Leu
Pathogenic
No assertion criteria
Myocardial infarction, susceptibility to, 1
Predictors lean, ClinVar uncertain 30
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCT7 p.Ala299Gly Uncertain significance Single submitter
- CCT7 p.Ala506Val Uncertain significance Single submitter
- CCT7 p.Arg126Cys Uncertain significance Single submitter
- CCT7 p.Arg344Gln Uncertain significance Single submitter
- CCT7 p.Arg387Gln Uncertain significance Single submitter
- CCT7 p.Arg499Gln Uncertain significance Single submitter
- CCT7 p.Asn501Ile Uncertain significance Single submitter
- CCT7 p.Asn60Lys Uncertain significance Single submitter
- CCT7 p.Asn60Ser Uncertain significance Single submitter
- CCT7 p.Asp70Gly Uncertain significance Single submitter
- CCT7 p.Glu11Val Uncertain significance Single submitter
- CCT7 p.Gly115Arg Uncertain significance Single submitter
- CCT7 p.Gly115Val Uncertain significance Single submitter
- CCT7 p.Gly471Trp Uncertain significance Single submitter
- CCT7 p.Gly538Asp Uncertain significance Single submitter
- CCT7 p.Ile237Thr Uncertain significance Single submitter
- CCT7 p.Ile295Thr Uncertain significance Single submitter
- CCT7 p.Ile395Met Uncertain significance Single submitter
- CCT7 p.Leu293Val Uncertain significance Single submitter
- CCT7 p.Leu416Phe Uncertain significance Single submitter
- CCT7 p.Lys366Glu Uncertain significance Single submitter
- CCT7 p.Pro235Arg Uncertain significance Single submitter
- CCT7 p.Pro446Ser Uncertain significance Single submitter
- CCT7 p.Ser507Phe Uncertain significance Single submitter
- CCT7 p.Thr129Ile Uncertain significance Single submitter
- CCT7 p.Thr473Ala Uncertain significance Single submitter
- CCT7 p.Thr519Ala Uncertain significance Single submitter
- CCT7 p.Val108Leu Uncertain significance Single submitter
- CCT7 p.Val341Met Uncertain significance Single submitter
- CCT7 p.Val514Met Uncertain significance Single submitter
Predictors split 25
The independent predictors disagree with each other — read with care.
- CCT7 p.Ala101Thr Uncertain significance Single submitter
- CCT7 p.Ala182Thr Uncertain significance Single submitter
- CCT7 p.Ala502Val Uncertain significance Single submitter
- CCT7 p.Ala510Val Uncertain significance Single submitter
- CCT7 p.Arg467Gly Uncertain significance Single submitter
- CCT7 p.Arg535Trp Uncertain significance Single submitter
- CCT7 p.Arg537His Uncertain significance Single submitter
- CCT7 p.Arg539Cys Uncertain significance Single submitter
- CCT7 p.Arg539Pro Uncertain significance Single submitter
- CCT7 p.Arg541His Uncertain significance Single submitter
- CCT7 p.Asn272Tyr Uncertain significance Single submitter
- CCT7 p.Gln346Arg Uncertain significance Single submitter
- CCT7 p.Gly471Ala Uncertain significance Single submitter
- CCT7 p.Ile484Val Uncertain significance Single submitter
- CCT7 p.Lys401Arg Uncertain significance Single submitter
- CCT7 p.Lys55Ile Uncertain significance Single submitter
- CCT7 p.Met160Val Uncertain significance Single submitter
- CCT7 p.Met497Val Uncertain significance Single submitter
- CCT7 p.Pro428Leu Uncertain significance Single submitter
- CCT7 p.Pro530Ser Uncertain significance Single submitter
- CCT7 p.Pro542Thr Uncertain significance Single submitter
- CCT7 p.Val143Met Uncertain significance Single submitter
- CCT7 p.Val23Met Uncertain significance Single submitter
- CCT7 p.Val516Ile Uncertain significance Single submitter
- CCT7 p.Val72Ile Uncertain significance Single submitter
All CCT7 variants
Pathogenic 1
- p.Ser525Leu No assertion criteria Myocardial infarction, susceptibility to, 1 ⚠
Uncertain significance 55
- p.Ala101Thr Single submitter ⚠
- p.Ala182Thr Single submitter ⚠
- p.Ala299Gly Single submitter ⚠
- p.Ala502Val Single submitter ⚠
- p.Ala506Val Single submitter ⚠
- p.Ala510Val Single submitter ⚠
- p.Arg126Cys Single submitter ⚠
- p.Arg344Gln Single submitter ⚠
- p.Arg387Gln Single submitter ⚠
- p.Arg467Gly Single submitter ⚠
- p.Arg499Gln Single submitter ⚠
- p.Arg535Trp Single submitter ⚠
- p.Arg537His Single submitter ⚠
- p.Arg539Cys Single submitter ⚠
- p.Arg539Pro Single submitter ⚠
- p.Arg541His Single submitter ⚠
- p.Asn272Tyr Single submitter ⚠
- p.Asn501Ile Single submitter ⚠
- p.Asn60Lys Single submitter ⚠
- p.Asn60Ser Single submitter ⚠
- p.Asp70Gly Single submitter ⚠
- p.Gln346Arg Single submitter ⚠
- p.Glu11Val Single submitter ⚠
- p.Gly115Arg Single submitter ⚠
- p.Gly115Val Single submitter ⚠
- p.Gly471Ala Single submitter ⚠
- p.Gly471Trp Single submitter ⚠
- p.Gly538Asp Single submitter ⚠
- p.Ile237Thr Single submitter ⚠
- p.Ile295Thr Single submitter ⚠
- p.Ile395Met Single submitter ⚠
- p.Ile484Val Single submitter ⚠
- p.Leu293Val Single submitter ⚠
- p.Leu416Phe Single submitter ⚠
- p.Lys366Glu Single submitter ⚠
- p.Lys401Arg Single submitter ⚠
- p.Lys55Ile Single submitter ⚠
- p.Met160Val Single submitter ⚠
- p.Met497Val Single submitter ⚠
- p.Pro235Arg Single submitter ⚠
- p.Pro428Leu Single submitter ⚠
- p.Pro446Ser Single submitter ⚠
- p.Pro530Ser Single submitter ⚠
- p.Pro542Thr Single submitter ⚠
- p.Ser507Phe Single submitter ⚠
- p.Thr129Ile Single submitter ⚠
- p.Thr473Ala Single submitter ⚠
- p.Thr519Ala Single submitter ⚠
- p.Val108Leu Single submitter ⚠
- p.Val143Met Single submitter ⚠
- p.Val23Met Single submitter ⚠
- p.Val341Met Single submitter ⚠
- p.Val514Met Single submitter ⚠
- p.Val516Ile Single submitter ⚠
- p.Val72Ile Single submitter ⚠