CCT8 — 75 ClinVar variants
All ClinVar germline CCT8 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 71 flagged for review →
1 Benign · 3 Likely benign · 71 Uncertain significance
Full CCT8 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 71
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 43
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCT8 p.Ala12Thr Uncertain significance Single submitter
- CCT8 p.Ala298Thr Uncertain significance Single submitter
- CCT8 p.Ala35Thr Uncertain significance Single submitter
- CCT8 p.Ala447Val Uncertain significance Single submitter
- CCT8 p.Ala451Thr Uncertain significance Single submitter
- CCT8 p.Ala8Pro Uncertain significance Single submitter
- CCT8 p.Arg404Gly Uncertain significance Single submitter
- CCT8 p.Arg520Gly Uncertain significance Single submitter
- CCT8 p.Asn102Lys Uncertain significance Single submitter
- CCT8 p.Asp158Glu Uncertain significance Single submitter
- CCT8 p.Asp405Val Uncertain significance Single submitter
- CCT8 p.Cys148Arg Uncertain significance Single submitter
- CCT8 p.Cys36Phe Uncertain significance Single submitter
- CCT8 p.Gln185Glu Uncertain significance Single submitter
- CCT8 p.Glu343Gly Uncertain significance Single submitter
- CCT8 p.Glu94Lys Uncertain significance Single submitter
- CCT8 p.Gly122Arg Uncertain significance Single submitter
- CCT8 p.Gly18Glu Uncertain significance Single submitter
- CCT8 p.Gly287Val Uncertain significance Single submitter
- CCT8 p.Gly370Ser Uncertain significance Single submitter
- CCT8 p.Ile190Val Uncertain significance Single submitter
- CCT8 p.Ile375Val Uncertain significance Single submitter
- CCT8 p.Leu112Val Uncertain significance Single submitter
- CCT8 p.Leu15Phe Uncertain significance Single submitter
- CCT8 p.Leu182Pro Uncertain significance Single submitter
- CCT8 p.Leu498Ile Uncertain significance Single submitter
- CCT8 p.Lys326Glu Uncertain significance Single submitter
- CCT8 p.Lys62Glu Uncertain significance Single submitter
- CCT8 p.Lys7Glu Uncertain significance Single submitter
- CCT8 p.Pro334Arg Uncertain significance Single submitter
- CCT8 p.Ser189Pro Uncertain significance Single submitter
- CCT8 p.Ser269Asn Uncertain significance Single submitter
- CCT8 p.Thr101Ile Uncertain significance Single submitter
- CCT8 p.Thr227Ala Uncertain significance Single submitter
- CCT8 p.Thr331Ile Uncertain significance Single submitter
- CCT8 p.Thr337Ala Uncertain significance Single submitter
- CCT8 p.Thr398Ser Uncertain significance Single submitter
- CCT8 p.Tyr30Phe Uncertain significance Single submitter
- CCT8 p.Val376Gly Uncertain significance Single submitter
- CCT8 p.Val458Ile Uncertain significance Single submitter
- CCT8 p.Val478Ile Uncertain significance Single submitter
- CCT8 p.Val518Ala Uncertain significance Single submitter
- CCT8 p.Val65Leu Uncertain significance Single submitter
Predictors split 28
The independent predictors disagree with each other — read with care.
- CCT8 p.Ala186Thr Uncertain significance Single submitter
- CCT8 p.Ala442Gly Uncertain significance Single submitter
- CCT8 p.Ala451Val Uncertain significance Single submitter
- CCT8 p.Arg155Gln Uncertain significance Single submitter
- CCT8 p.Arg407Cys Uncertain significance Single submitter
- CCT8 p.Arg44His Uncertain significance Single submitter
- CCT8 p.Asn67Thr Uncertain significance Single submitter
- CCT8 p.Asp544Val Uncertain significance Single submitter
- CCT8 p.Cys430Ser Uncertain significance Single submitter
- CCT8 p.Glu434Gln Uncertain significance Single submitter
- CCT8 p.Gly100Asp Uncertain significance Single submitter
- CCT8 p.Gly412Ser Uncertain significance Single submitter
- CCT8 p.Ile157Thr Uncertain significance Single submitter
- CCT8 p.Ile508Val Uncertain significance Single submitter
- CCT8 p.Lys400Arg Uncertain significance Single submitter
- CCT8 p.Lys476Asn Uncertain significance Single submitter
- CCT8 p.Lys540Glu Uncertain significance Single submitter
- CCT8 p.Phe22Leu Uncertain significance Single submitter
- CCT8 p.Pro535Ser Uncertain significance Single submitter
- CCT8 p.Ser233Thr Uncertain significance Single submitter
- CCT8 p.Thr232Ala Uncertain significance Single submitter
- CCT8 p.Thr512Ile Uncertain significance Single submitter
- CCT8 p.Thr71Ala Uncertain significance Single submitter
- CCT8 p.Tyr308Cys Uncertain significance Single submitter
- CCT8 p.Tyr351Asp Uncertain significance Single submitter
- CCT8 p.Tyr351Cys Likely benign Single submitter
- CCT8 p.Val313Met Uncertain significance Single submitter
- CCT8 p.Val87Ile Uncertain significance Single submitter
All CCT8 variants
Benign 1
- p.Val409Ile Multiple submitters
Likely benign 3
- p.Ser194= Single submitter
- p.Tyr351Cys Single submitter ⚠
- p.Val291Ile Single submitter
Uncertain significance 71
- p.Ala12Thr Single submitter ⚠
- p.Ala186Thr Single submitter ⚠
- p.Ala298Thr Single submitter ⚠
- p.Ala35Thr Single submitter ⚠
- p.Ala442Gly Single submitter ⚠
- p.Ala447Val Single submitter ⚠
- p.Ala451Thr Single submitter ⚠
- p.Ala451Val Single submitter ⚠
- p.Ala8Pro Single submitter ⚠
- p.Arg155Gln Single submitter ⚠
- p.Arg404Gly Single submitter ⚠
- p.Arg407Cys Single submitter ⚠
- p.Arg44His Single submitter ⚠
- p.Arg520Gly Single submitter ⚠
- p.Asn102Lys Single submitter ⚠
- p.Asn67Thr Single submitter ⚠
- p.Asp158Glu Single submitter ⚠
- p.Asp405Val Single submitter ⚠
- p.Asp544Val Single submitter ⚠
- p.Cys148Arg Single submitter ⚠
- p.Cys36Phe Single submitter ⚠
- p.Cys430Ser Single submitter ⚠
- p.Gln185Glu Single submitter ⚠
- p.Glu343Gly Single submitter ⚠
- p.Glu434Gln Single submitter ⚠
- p.Glu94Lys Single submitter ⚠
- p.Gly100Asp Single submitter ⚠
- p.Gly122Arg Single submitter ⚠
- p.Gly18Glu Single submitter ⚠
- p.Gly287Val Single submitter ⚠
- p.Gly370Ser Single submitter ⚠
- p.Gly412Ser Single submitter ⚠
- p.Ile157Thr Single submitter ⚠
- p.Ile190Val Single submitter ⚠
- p.Ile375Val Single submitter ⚠
- p.Ile508Val Single submitter ⚠
- p.Leu112Val Single submitter ⚠
- p.Leu15Phe Single submitter ⚠
- p.Leu182Pro Single submitter ⚠
- p.Leu498Ile Single submitter ⚠
- p.Lys326Glu Single submitter ⚠
- p.Lys400Arg Single submitter ⚠
- p.Lys476Asn Single submitter ⚠
- p.Lys540Glu Single submitter ⚠
- p.Lys62Glu Single submitter ⚠
- p.Lys7Glu Single submitter ⚠
- p.Phe22Leu Single submitter ⚠
- p.Pro334Arg Single submitter ⚠
- p.Pro535Ser Single submitter ⚠
- p.Ser189Pro Single submitter ⚠
- p.Ser233Thr Single submitter ⚠
- p.Ser269Asn Single submitter ⚠
- p.Thr101Ile Single submitter ⚠
- p.Thr227Ala Single submitter ⚠
- p.Thr232Ala Single submitter ⚠
- p.Thr331Ile Single submitter ⚠
- p.Thr337Ala Single submitter ⚠
- p.Thr398Ser Single submitter ⚠
- p.Thr512Ile Single submitter ⚠
- p.Thr71Ala Single submitter ⚠
- p.Tyr308Cys Single submitter ⚠
- p.Tyr30Phe Single submitter ⚠
- p.Tyr351Asp Single submitter ⚠
- p.Val313Met Single submitter ⚠
- p.Val376Gly Single submitter ⚠
- p.Val458Ile Single submitter ⚠
- p.Val478Ile Single submitter ⚠
- p.Val518Ala Single submitter ⚠
- p.Val65Leu Single submitter ⚠
- p.Val87Ile Single submitter ⚠
- p.Asn309fs No assertion criteria