CD163 — 126 ClinVar variants
All ClinVar germline CD163 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 106 flagged for review →
10 Benign · 9 Likely benign · 107 Uncertain significance
Full CD163 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 106
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 57
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CD163 c.3344-41T>C Uncertain significance Single submitter
- CD163 c.3344-75C>T Uncertain significance Single submitter
- CD163 c.3344-8T>C Uncertain significance Single submitter
- CD163 p.Ala1025Ser Uncertain significance Single submitter
- CD163 p.Ala104Gly Uncertain significance Single submitter
- CD163 p.Ala303Thr Uncertain significance Single submitter
- CD163 p.Ala666Thr Uncertain significance Single submitter
- CD163 p.Arg1047His Uncertain significance Single submitter
- CD163 p.Arg112His Uncertain significance Single submitter
- CD163 p.Arg121His Uncertain significance Single submitter
- CD163 p.Arg163His Uncertain significance Single submitter
- CD163 p.Arg18Ser Uncertain significance Single submitter
- CD163 p.Asn23Thr Uncertain significance Single submitter
- CD163 p.Asn537Asp Uncertain significance Single submitter
- CD163 p.Asn609Ser Uncertain significance Single submitter
- CD163 p.Asn789Ser Uncertain significance Single submitter
- CD163 p.Asn994Ser Uncertain significance Single submitter
- CD163 p.Asp55His Uncertain significance Single submitter
- CD163 p.Asp900Ala Uncertain significance Single submitter
- CD163 p.Cys291Phe Uncertain significance Single submitter
- CD163 p.Cys355Phe Uncertain significance Single submitter
- CD163 p.Cys626Trp Uncertain significance Single submitter
- CD163 p.Cys925Ser Uncertain significance Single submitter
- CD163 p.Cys998Tyr Uncertain significance Single submitter
- CD163 p.Gln145Lys Uncertain significance Single submitter
- CD163 p.Gln425Arg Uncertain significance Single submitter
- CD163 p.Gln718Arg Uncertain significance Single submitter
- CD163 p.Glu201Lys Uncertain significance Single submitter
- CD163 p.Gly294Ser Uncertain significance Single submitter
- CD163 p.Gly802Ser Uncertain significance Single submitter
- CD163 p.His464Arg Uncertain significance Single submitter
- CD163 p.His651Tyr Uncertain significance Single submitter
- CD163 p.His754Arg Uncertain significance Single submitter
- CD163 p.Ile705Thr Uncertain significance Single submitter
- CD163 p.Ile714Leu Uncertain significance Single submitter
- CD163 p.Leu515Val Uncertain significance Single submitter
- CD163 p.Lys137Arg Uncertain significance Single submitter
- CD163 p.Lys997Asn Uncertain significance Single submitter
- CD163 p.Lys999Gln Uncertain significance Single submitter
- CD163 p.Lys99Gln Uncertain significance Single submitter
- CD163 p.Met649Leu Uncertain significance Single submitter
- CD163 p.Met822Thr Uncertain significance Single submitter
- CD163 p.Met82Val Uncertain significance Single submitter
- CD163 p.Met884Val Uncertain significance Single submitter
- CD163 p.Pro26Leu Uncertain significance Single submitter
- CD163 p.Pro700Leu Uncertain significance Single submitter
- CD163 p.Ser1045Leu Uncertain significance Single submitter
- CD163 p.Ser42Thr Uncertain significance Single submitter
- CD163 p.Ser747Thr Uncertain significance Single submitter
- CD163 p.Thr1041Pro Uncertain significance Single submitter
- CD163 p.Trp72Ser Uncertain significance Single submitter
- CD163 p.Val118Ile Uncertain significance Single submitter
- CD163 p.Val269Ala Uncertain significance Single submitter
- CD163 p.Val628Ile Uncertain significance Single submitter
- CD163 p.Val756Ala Uncertain significance Single submitter
- CD163 p.Val841Ile Uncertain significance Single submitter
- CD163 p.Val890Met Uncertain significance Single submitter
Predictors split 49
The independent predictors disagree with each other — read with care.
- CD163 p.Ile342Val Benign Multiple submitters
- CD163 p.Ser570Asn Benign Multiple submitters
- CD163 p.Ala1025Glu Uncertain significance Single submitter
- CD163 p.Ala1025Thr Uncertain significance Single submitter
- CD163 p.Ala1053Thr Uncertain significance Single submitter
- CD163 p.Ala126Asp Uncertain significance Single submitter
- CD163 p.Ala768Ser Uncertain significance Single submitter
- CD163 p.Arg1097Trp Uncertain significance Single submitter
- CD163 p.Arg163Cys Uncertain significance Single submitter
- CD163 p.Arg381His Uncertain significance Single submitter
- CD163 p.Arg490His Uncertain significance Single submitter
- CD163 p.Arg584His Uncertain significance Single submitter
- CD163 p.Arg794Gly Uncertain significance Single submitter
- CD163 p.Arg930Ile Uncertain significance Single submitter
- CD163 p.Asn156Thr Uncertain significance Single submitter
- CD163 p.Asn77Thr Uncertain significance Single submitter
- CD163 p.Asp129Gly Uncertain significance Single submitter
- CD163 p.Asp270Val Uncertain significance Single submitter
- CD163 p.Asp745Glu Uncertain significance Single submitter
- CD163 p.Glu785Gly Uncertain significance Single submitter
- CD163 p.Glu857Lys Uncertain significance Single submitter
- CD163 p.Gly444Arg Uncertain significance Single submitter
- CD163 p.Gly534Arg Uncertain significance Single submitter
- CD163 p.Gly536Ala Uncertain significance Single submitter
- CD163 p.Gly643Val Uncertain significance Single submitter
- CD163 p.Gly790Glu Uncertain significance Single submitter
- CD163 p.Ile1052Phe Uncertain significance Single submitter
- CD163 p.Leu1061Pro Uncertain significance Single submitter
- CD163 p.Leu554Phe Uncertain significance Single submitter
- CD163 p.Leu630Phe Uncertain significance Single submitter
- CD163 p.Lys811Glu Uncertain significance Single submitter
- CD163 p.Pro591Leu Uncertain significance Single submitter
- CD163 p.Ser204Arg Uncertain significance Single submitter
- CD163 p.Ser207Arg Uncertain significance Single submitter
- CD163 p.Ser473Leu Uncertain significance Single submitter
- CD163 p.Ser568Arg Uncertain significance Single submitter
- CD163 p.Ser908Tyr Uncertain significance Single submitter
- CD163 p.Ser918Leu Uncertain significance Single submitter
- CD163 p.Trp402Arg Uncertain significance Single submitter
- CD163 p.Trp457Arg Uncertain significance Single submitter
- CD163 p.Val269Glu Uncertain significance Single submitter
- CD163 p.Val386Ile Uncertain significance Single submitter
- CD163 p.Val388Leu Uncertain significance Single submitter
- CD163 p.Val491Ile Uncertain significance Single submitter
- CD163 p.Val514Ile Uncertain significance Single submitter
- CD163 p.Val576Leu Uncertain significance Single submitter
- CD163 p.Val722Ile Uncertain significance Single submitter
- CD163 p.Val863Met Uncertain significance Single submitter
- CD163 p.Val942Met Uncertain significance Single submitter
All CD163 variants
Benign 10
- c.3344-24C>A Multiple submitters
- c.457+9T>A Multiple submitters
- p.Asn642Lys Multiple submitters
- p.Asn892= Multiple submitters
- p.Cys1008= Multiple submitters
- p.Ile342Val Multiple submitters ⚠
- p.Leu867= Multiple submitters
- p.Ser570Asn Multiple submitters ⚠
- p.Thr74= Multiple submitters
- p.Thr921= Single submitter
Likely benign 9
- c.3344-56G>A Multiple submitters
- p.Arg1044His Single submitter
- p.Arg562= Single submitter
- p.Arg637His Single submitter
- p.His799Arg Single submitter
- p.Leu1071Trp Single submitter
- p.Phe1069Leu Single submitter
- p.Thr162= Single submitter
- p.Val1060Ile Single submitter
Uncertain significance 107
- c.1100-317C>A Single submitter squamous cell carcinoma
- c.3344-144C>G Single submitter lung adenocarcinoma
- c.3344-41T>C Single submitter ⚠
- c.3344-75C>T Single submitter ⚠
- c.3344-8T>C Single submitter ⚠
- p.Ala1025Glu Single submitter ⚠
- p.Ala1025Ser Single submitter ⚠
- p.Ala1025Thr Single submitter ⚠
- p.Ala104Gly Single submitter ⚠
- p.Ala1053Thr Single submitter ⚠
- p.Ala126Asp Single submitter ⚠
- p.Ala15= Single submitter lung adenocarcinoma
- p.Ala303Thr Single submitter ⚠
- p.Ala666Thr Single submitter ⚠
- p.Ala768Ser Single submitter ⚠
- p.Arg1047His Single submitter ⚠
- p.Arg1097Trp Single submitter ⚠
- p.Arg112His Single submitter ⚠
- p.Arg121His Single submitter ⚠
- p.Arg163Cys Single submitter ⚠
- p.Arg163His Single submitter ⚠
- p.Arg18Ser Single submitter ⚠
- p.Arg381His Single submitter ⚠
- p.Arg490His Single submitter ⚠
- p.Arg584His Single submitter ⚠
- p.Arg794Gly Single submitter ⚠
- p.Arg930Ile Single submitter ⚠
- p.Asn156Thr Single submitter ⚠
- p.Asn23Thr Single submitter ⚠
- p.Asn537Asp Single submitter ⚠
- p.Asn609Ser Single submitter ⚠
- p.Asn77Thr Single submitter ⚠
- p.Asn789Ser Single submitter ⚠
- p.Asn994Ser Single submitter ⚠
- p.Asp129Gly Single submitter ⚠
- p.Asp270Val Single submitter ⚠
- p.Asp55His Single submitter ⚠
- p.Asp745Glu Single submitter ⚠
- p.Asp900Ala Single submitter ⚠
- p.Cys291Phe Single submitter ⚠
- p.Cys355Phe Single submitter ⚠
- p.Cys626Trp Single submitter ⚠
- p.Cys925Ser Single submitter ⚠
- p.Cys998Tyr Single submitter ⚠
- p.Gln145Lys Single submitter ⚠
- p.Gln425Arg Single submitter ⚠
- p.Gln718Arg Single submitter ⚠
- p.Glu201Lys Single submitter ⚠
- p.Glu785Gly Single submitter ⚠
- p.Glu857Lys Single submitter ⚠
- p.Gly294Ser Single submitter ⚠
- p.Gly444Arg Single submitter ⚠
- p.Gly534Arg Single submitter ⚠
- p.Gly536Ala Single submitter ⚠
- p.Gly643Val Single submitter ⚠
- p.Gly790Glu Single submitter ⚠
- p.Gly802Ser Single submitter ⚠
- p.His464Arg Single submitter ⚠
- p.His651Tyr Single submitter ⚠
- p.His754Arg Single submitter ⚠
- p.Ile1052Phe Single submitter ⚠
- p.Ile705Thr Single submitter ⚠
- p.Ile714Leu Single submitter ⚠
- p.Leu1061Pro Single submitter ⚠
- p.Leu515Val Single submitter ⚠
- p.Leu554Phe Single submitter ⚠
- p.Leu630Phe Single submitter ⚠
- p.Lys137Arg Single submitter ⚠
- p.Lys811Glu Single submitter ⚠
- p.Lys997Asn Single submitter ⚠
- p.Lys999Gln Single submitter ⚠
- p.Lys99Gln Single submitter ⚠
- p.Met649Leu Single submitter ⚠
- p.Met822Thr Single submitter ⚠
- p.Met82Val Single submitter ⚠
- p.Met884Val Single submitter ⚠
- p.Pro26Leu Single submitter ⚠
- p.Pro591Leu Single submitter ⚠
- p.Pro700Leu Single submitter ⚠
- p.Ser1045Leu Single submitter ⚠
- p.Ser204Arg Single submitter ⚠
- p.Ser207Arg Single submitter ⚠
- p.Ser42Thr Single submitter ⚠
- p.Ser473Leu Single submitter ⚠
- p.Ser568Arg Single submitter ⚠
- p.Ser747Thr Single submitter ⚠
- p.Ser908Tyr Single submitter ⚠
- p.Ser918Leu Single submitter ⚠
- p.Thr1041Pro Single submitter ⚠
- p.Trp402Arg Single submitter ⚠
- p.Trp457Arg Single submitter ⚠
- p.Trp72Ser Single submitter ⚠
- p.Val118Ile Single submitter ⚠
- p.Val269Ala Single submitter ⚠
- p.Val269Glu Single submitter ⚠
- p.Val386Ile Single submitter ⚠
- p.Val388Leu Single submitter ⚠
- p.Val491Ile Single submitter ⚠
- p.Val514Ile Single submitter ⚠
- p.Val576Leu Single submitter ⚠
- p.Val628Ile Single submitter ⚠
- p.Val722Ile Single submitter ⚠
- p.Val756Ala Single submitter ⚠
- p.Val841Ile Single submitter ⚠
- p.Val863Met Single submitter ⚠
- p.Val890Met Single submitter ⚠
- p.Val942Met Single submitter ⚠