CD163L1 — 190 ClinVar variants
All ClinVar germline CD163L1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 158 flagged for review →
1 Benign · 29 Likely benign · 160 Uncertain significance
Full CD163L1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 158
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 123
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CD163L1 p.Ala1012Thr Uncertain significance Single submitter
- CD163L1 p.Ala1175Val Uncertain significance Single submitter
- CD163L1 p.Ala1195Thr Uncertain significance Single submitter
- CD163L1 p.Ala1264Ser Uncertain significance Single submitter
- CD163L1 p.Ala1299Thr Uncertain significance Single submitter
- CD163L1 p.Ala1327Thr Uncertain significance Single submitter
- CD163L1 p.Ala1355Val Uncertain significance Single submitter
- CD163L1 p.Ala454Thr Uncertain significance Single submitter
- CD163L1 p.Ala481Ser Uncertain significance Single submitter
- CD163L1 p.Ala579Thr Uncertain significance Single submitter
- CD163L1 p.Ala616Thr Uncertain significance Single submitter
- CD163L1 p.Ala618Asp Uncertain significance Single submitter
- CD163L1 p.Ala724Ser Uncertain significance Single submitter
- CD163L1 p.Ala778Val Uncertain significance Single submitter
- CD163L1 p.Arg1037His Uncertain significance Single submitter
- CD163L1 p.Arg1044His Uncertain significance Single submitter
- CD163L1 p.Arg106Ile Uncertain significance Single submitter
- CD163L1 p.Arg1126Gly Uncertain significance Single submitter
- CD163L1 p.Arg130Gln Uncertain significance Single submitter
- CD163L1 p.Arg1400Lys Uncertain significance Single submitter
- CD163L1 p.Arg215Ser Uncertain significance Single submitter
- CD163L1 p.Arg420Cys Uncertain significance Single submitter
- CD163L1 p.Arg420His Uncertain significance Single submitter
- CD163L1 p.Arg421His Uncertain significance Single submitter
- CD163L1 p.Arg460Gln Uncertain significance Single submitter
- CD163L1 p.Arg817His Uncertain significance Single submitter
- CD163L1 p.Arg961His Uncertain significance Single submitter
- CD163L1 p.Arg961Pro Uncertain significance Single submitter
- CD163L1 p.Asn1354Asp Uncertain significance Single submitter
- CD163L1 p.Asn162Thr Uncertain significance Single submitter
- CD163L1 p.Asn247Asp Uncertain significance Single submitter
- CD163L1 p.Asn334Ser Uncertain significance Single submitter
- CD163L1 p.Asn348Ser Uncertain significance Single submitter
- CD163L1 p.Asn590His Uncertain significance Single submitter
- CD163L1 p.Asn717Asp Uncertain significance Single submitter
- CD163L1 p.Asp1054His Uncertain significance Single submitter
- CD163L1 p.Asp1252Gly Uncertain significance Single submitter
- CD163L1 p.Asp1439Asn Uncertain significance Single submitter
- CD163L1 p.Asp340Gly Uncertain significance Single submitter
- CD163L1 p.Asp350Tyr Uncertain significance Single submitter
- CD163L1 p.Cys287Gly Uncertain significance Single submitter
- CD163L1 p.Cys300Arg Uncertain significance Single submitter
- CD163L1 p.Cys652Tyr Uncertain significance Single submitter
- CD163L1 p.Cys728Tyr Uncertain significance Single submitter
- CD163L1 p.Cys733Arg Uncertain significance Single submitter
- CD163L1 p.Gln280Leu Uncertain significance Single submitter
- CD163L1 p.Gln494Glu Uncertain significance Single submitter
- CD163L1 p.Gln68Arg Uncertain significance Single submitter
- CD163L1 p.Glu1254Lys Uncertain significance Single submitter
- CD163L1 p.Glu1405Gln Uncertain significance Single submitter
- CD163L1 p.Glu1418Gln Uncertain significance Single submitter
- CD163L1 p.Glu881Ala Uncertain significance Single submitter
- CD163L1 p.Gly1025Asp Uncertain significance Single submitter
- CD163L1 p.Gly1078Asp Uncertain significance Single submitter
- CD163L1 p.Gly108Ala Uncertain significance Single submitter
- CD163L1 p.Gly108Glu Uncertain significance Single submitter
- CD163L1 p.Gly1268Asp Uncertain significance Single submitter
- CD163L1 p.Gly140Arg Uncertain significance Single submitter
- CD163L1 p.Gly273Glu Uncertain significance Single submitter
- CD163L1 p.Gly345Arg Uncertain significance Single submitter
- CD163L1 p.Gly559Val Uncertain significance Single submitter
- CD163L1 p.Gly602Arg Uncertain significance Single submitter
- CD163L1 p.Gly911Arg Uncertain significance Single submitter
- CD163L1 p.His1216Arg Uncertain significance Single submitter
- CD163L1 p.His1409Pro Uncertain significance Single submitter
- CD163L1 p.His1421Pro Uncertain significance Single submitter
- CD163L1 p.His524Tyr Uncertain significance Single submitter
- CD163L1 p.His812Tyr Uncertain significance Single submitter
- CD163L1 p.His870Gln Uncertain significance Single submitter
- CD163L1 p.His879Tyr Uncertain significance Single submitter
- CD163L1 p.Ile1176Val Uncertain significance Single submitter
- CD163L1 p.Ile1217Ser Uncertain significance Single submitter
- CD163L1 p.Ile1219Met Uncertain significance Single submitter
- CD163L1 p.Ile1246Val Uncertain significance Single submitter
- CD163L1 p.Ile538Val Uncertain significance Single submitter
- CD163L1 p.Ile546Thr Uncertain significance Single submitter
- CD163L1 p.Ile955Val Uncertain significance Single submitter
- CD163L1 p.Leu1370Ile Uncertain significance Single submitter
- CD163L1 p.Leu214Trp Uncertain significance Single submitter
- CD163L1 p.Leu264Pro Uncertain significance Single submitter
- CD163L1 p.Leu317Val Uncertain significance Single submitter
- CD163L1 p.Leu766Phe Uncertain significance Single submitter
- CD163L1 p.Leu984Ile Uncertain significance Single submitter
- CD163L1 p.Lys408Arg Uncertain significance Single submitter
- CD163L1 p.Lys87Arg Uncertain significance Single submitter
- CD163L1 p.Met688Thr Uncertain significance Single submitter
- CD163L1 p.Met721Thr Uncertain significance Single submitter
- CD163L1 p.Met754Val Uncertain significance Single submitter
- CD163L1 p.Met981Leu Uncertain significance Single submitter
- CD163L1 p.Ser1349Leu Uncertain significance Single submitter
- CD163L1 p.Ser134Gly Uncertain significance Single submitter
- CD163L1 p.Ser1426Pro Uncertain significance Single submitter
- CD163L1 p.Ser204Phe Uncertain significance Single submitter
- CD163L1 p.Ser319Thr Uncertain significance Single submitter
- CD163L1 p.Ser443Thr Uncertain significance Single submitter
- CD163L1 p.Ser790Leu Uncertain significance Single submitter
- CD163L1 p.Ser7Leu Uncertain significance Single submitter
- CD163L1 p.Ser825Pro Uncertain significance Single submitter
- CD163L1 p.Ser867Arg Uncertain significance Single submitter
- CD163L1 p.Ser887Thr Uncertain significance Single submitter
- CD163L1 p.Ser959Asn Uncertain significance Single submitter
- CD163L1 p.Thr1000Arg Uncertain significance Single submitter
- CD163L1 p.Thr1000Ile Uncertain significance Single submitter
- CD163L1 p.Thr1215Met Uncertain significance Single submitter
- CD163L1 p.Thr1397Ala Uncertain significance Single submitter
- CD163L1 p.Thr188Ala Uncertain significance Single submitter
- CD163L1 p.Thr27Ala Uncertain significance Single submitter
- CD163L1 p.Trp283Ser Uncertain significance Single submitter
- CD163L1 p.Trp612Cys Uncertain significance Single submitter
- CD163L1 p.Tyr642Cys Uncertain significance Single submitter
- CD163L1 p.Tyr954Cys Uncertain significance Single submitter
- CD163L1 p.Val1014Ile Uncertain significance Single submitter
- CD163L1 p.Val1081Glu Uncertain significance Single submitter
- CD163L1 p.Val1167Ile Uncertain significance Single submitter
- CD163L1 p.Val1374Ala Uncertain significance Single submitter
- CD163L1 p.Val158Met Uncertain significance Single submitter
- CD163L1 p.Val25Gly Uncertain significance Single submitter
- CD163L1 p.Val347Ile Uncertain significance Single submitter
- CD163L1 p.Val543Ile Uncertain significance Single submitter
- CD163L1 p.Val703Ile Uncertain significance Single submitter
- CD163L1 p.Val711Met Uncertain significance Single submitter
- CD163L1 p.Val798Ile Uncertain significance Single submitter
- CD163L1 p.Val960Ala Uncertain significance Single submitter
Predictors split 35
The independent predictors disagree with each other — read with care.
- CD163L1 p.Ala1046Val Uncertain significance Single submitter
- CD163L1 p.Ala123Gly Uncertain significance Single submitter
- CD163L1 p.Arg1314Trp Uncertain significance Single submitter
- CD163L1 p.Arg274Ser Uncertain significance Single submitter
- CD163L1 p.Arg591Leu Likely benign Single submitter
- CD163L1 p.Arg729Gly Uncertain significance Single submitter
- CD163L1 p.Arg817Cys Uncertain significance Single submitter
- CD163L1 p.Arg935Cys Uncertain significance Single submitter
- CD163L1 p.Asp1063Val Uncertain significance Single submitter
- CD163L1 p.Asp1124Gly Uncertain significance Single submitter
- CD163L1 p.Asp220Asn Uncertain significance Single submitter
- CD163L1 p.Asp249Gly Uncertain significance Single submitter
- CD163L1 p.Asp648His Uncertain significance Single submitter
- CD163L1 p.Asp677Glu Uncertain significance Single submitter
- CD163L1 p.Cys407Ser Uncertain significance Single submitter
- CD163L1 p.Cys412Tyr Uncertain significance Single submitter
- CD163L1 p.Cys699Ser Uncertain significance Single submitter
- CD163L1 p.Gln302His Uncertain significance Single submitter
- CD163L1 p.Gln409Pro Uncertain significance Single submitter
- CD163L1 p.Glu1319Asp Uncertain significance Single submitter
- CD163L1 p.Glu248Val Uncertain significance Single submitter
- CD163L1 p.Gly1190Arg Uncertain significance Single submitter
- CD163L1 p.Gly1251Arg Uncertain significance Single submitter
- CD163L1 p.Gly183Val Uncertain significance Single submitter
- CD163L1 p.Gly320Arg Uncertain significance Single submitter
- CD163L1 p.Gly641Arg Uncertain significance Single submitter
- CD163L1 p.Gly695Arg Uncertain significance Single submitter
- CD163L1 p.His1127Gln Uncertain significance Single submitter
- CD163L1 p.His1337Gln Uncertain significance Single submitter
- CD163L1 p.Leu264Phe Uncertain significance Single submitter
- CD163L1 p.Ser544Pro Uncertain significance Single submitter
- CD163L1 p.Trp132Arg Uncertain significance Single submitter
- CD163L1 p.Trp176Gly Uncertain significance Single submitter
- CD163L1 p.Trp646Arg Uncertain significance Single submitter
- CD163L1 p.Val726Ala Uncertain significance Single submitter
All CD163L1 variants
Benign 1
- p.Ser1274Tyr Single submitter
Likely benign 29
- p.Ala1012Ser Single submitter
- p.Ala1131= Single submitter
- p.Ala96Thr Single submitter
- p.Arg1118= Single submitter
- p.Arg1118His Single submitter
- p.Arg1126= Single submitter
- p.Arg1314Gln Single submitter
- p.Arg591Leu Single submitter ⚠
- p.Arg603Gln Single submitter
- p.Arg738Lys Single submitter
- p.Asn162Ser Single submitter
- p.Asp1101= Single submitter
- p.Glu1093= Single submitter
- p.Glu388Gly Single submitter
- p.Glu556Lys Single submitter
- p.Gly1055Ser Single submitter
- p.Gly1094= Single submitter
- p.Gly1250Glu Single submitter
- p.Met272Val Single submitter
- p.Met981Val Single submitter
- p.Phe1091= Single submitter
- p.Ser1356Pro Single submitter
- p.Thr1174Ala Single submitter
- p.Thr574Ile Single submitter
- p.Val1081= Single submitter
- p.Val1087= Single submitter
- p.Val416Ile Single submitter
- p.Val566Ile Single submitter
- p.Glu725Asp No assertion criteria EBV-positive nodal T- and NK-cell lymphoma
Uncertain significance 160
- p.Ala1012Thr Single submitter ⚠
- p.Ala1046Val Single submitter ⚠
- p.Ala1175Val Single submitter ⚠
- p.Ala1195Thr Single submitter ⚠
- p.Ala123Gly Single submitter ⚠
- p.Ala1264Ser Single submitter ⚠
- p.Ala1299Thr Single submitter ⚠
- p.Ala1327Thr Single submitter ⚠
- p.Ala1355Val Single submitter ⚠
- p.Ala454Thr Single submitter ⚠
- p.Ala481Ser Single submitter ⚠
- p.Ala579Thr Single submitter ⚠
- p.Ala616Thr Single submitter ⚠
- p.Ala618Asp Single submitter ⚠
- p.Ala724Ser Single submitter ⚠
- p.Ala778Val Single submitter ⚠
- p.Arg1037His Single submitter ⚠
- p.Arg1044His Single submitter ⚠
- p.Arg106Ile Single submitter ⚠
- p.Arg1126Gly Single submitter ⚠
- p.Arg130Gln Single submitter ⚠
- p.Arg1314Trp Single submitter ⚠
- p.Arg1400Lys Single submitter ⚠
- p.Arg167Thr Single submitter
- p.Arg215Ser Single submitter ⚠
- p.Arg274Ser Single submitter ⚠
- p.Arg420Cys Single submitter ⚠
- p.Arg420His Single submitter ⚠
- p.Arg421His Single submitter ⚠
- p.Arg460Gln Single submitter ⚠
- p.Arg729Gly Single submitter ⚠
- p.Arg817Cys Single submitter ⚠
- p.Arg817His Single submitter ⚠
- p.Arg935Cys Single submitter ⚠
- p.Arg961His Single submitter ⚠
- p.Arg961Pro Single submitter ⚠
- p.Asn1354Asp Single submitter ⚠
- p.Asn162Thr Single submitter ⚠
- p.Asn247Asp Single submitter ⚠
- p.Asn334Ser Single submitter ⚠
- p.Asn348Ser Single submitter ⚠
- p.Asn590His Single submitter ⚠
- p.Asn717Asp Single submitter ⚠
- p.Asp1054His Single submitter ⚠
- p.Asp1063Val Single submitter ⚠
- p.Asp1124Gly Single submitter ⚠
- p.Asp1252Gly Single submitter ⚠
- p.Asp1439Asn Single submitter ⚠
- p.Asp220Asn Single submitter ⚠
- p.Asp249Gly Single submitter ⚠
- p.Asp340Gly Single submitter ⚠
- p.Asp350Tyr Single submitter ⚠
- p.Asp648His Single submitter ⚠
- p.Asp677Glu Single submitter ⚠
- p.Cys287Gly Single submitter ⚠
- p.Cys300Arg Single submitter ⚠
- p.Cys407Ser Single submitter ⚠
- p.Cys412Tyr Single submitter ⚠
- p.Cys652Tyr Single submitter ⚠
- p.Cys699Ser Single submitter ⚠
- p.Cys728Tyr Single submitter ⚠
- p.Cys733Arg Single submitter ⚠
- p.Gln280Leu Single submitter ⚠
- p.Gln302His Single submitter ⚠
- p.Gln409Pro Single submitter ⚠
- p.Gln494Glu Single submitter ⚠
- p.Gln68Arg Single submitter ⚠
- p.Glu121Lys Single submitter
- p.Glu1254Lys Single submitter ⚠
- p.Glu1319Asp Single submitter ⚠
- p.Glu1405Gln Single submitter ⚠
- p.Glu1418Gln Single submitter ⚠
- p.Glu248Val Single submitter ⚠
- p.Glu881Ala Single submitter ⚠
- p.Gly1025Asp Single submitter ⚠
- p.Gly1078Asp Single submitter ⚠
- p.Gly108Ala Single submitter ⚠
- p.Gly108Glu Single submitter ⚠
- p.Gly1190Arg Single submitter ⚠
- p.Gly1251Arg Single submitter ⚠
- p.Gly1268Asp Single submitter ⚠
- p.Gly140Arg Single submitter ⚠
- p.Gly183Val Single submitter ⚠
- p.Gly273Glu Single submitter ⚠
- p.Gly320Arg Single submitter ⚠
- p.Gly345Arg Single submitter ⚠
- p.Gly559Val Single submitter ⚠
- p.Gly602Arg Single submitter ⚠
- p.Gly641Arg Single submitter ⚠
- p.Gly695Arg Single submitter ⚠
- p.Gly911Arg Single submitter ⚠
- p.His1127Gln Single submitter ⚠
- p.His1216Arg Single submitter ⚠
- p.His1337Gln Single submitter ⚠
- p.His1409Pro Single submitter ⚠
- p.His1421Pro Single submitter ⚠
- p.His524Tyr Single submitter ⚠
- p.His812Tyr Single submitter ⚠
- p.His870Gln Single submitter ⚠
- p.His879Tyr Single submitter ⚠
- p.Ile1176Val Single submitter ⚠
- p.Ile1217Ser Single submitter ⚠
- p.Ile1219Met Single submitter ⚠
- p.Ile1246Val Single submitter ⚠
- p.Ile538Val Single submitter ⚠
- p.Ile546Thr Single submitter ⚠
- p.Ile955Val Single submitter ⚠
- p.Leu1287Arg Single submitter
- p.Leu1370Ile Single submitter ⚠
- p.Leu214Trp Single submitter ⚠
- p.Leu264Phe Single submitter ⚠
- p.Leu264Pro Single submitter ⚠
- p.Leu317Val Single submitter ⚠
- p.Leu766Phe Single submitter ⚠
- p.Leu984Ile Single submitter ⚠
- p.Lys408Arg Single submitter ⚠
- p.Lys87Arg Single submitter ⚠
- p.Met688Thr Single submitter ⚠
- p.Met721Thr Single submitter ⚠
- p.Met754Val Single submitter ⚠
- p.Met981Leu Single submitter ⚠
- p.Ser1349Leu Single submitter ⚠
- p.Ser134Gly Single submitter ⚠
- p.Ser1426Pro Single submitter ⚠
- p.Ser204Phe Single submitter ⚠
- p.Ser319Thr Single submitter ⚠
- p.Ser443Thr Single submitter ⚠
- p.Ser544Pro Single submitter ⚠
- p.Ser790Leu Single submitter ⚠
- p.Ser7Leu Single submitter ⚠
- p.Ser825Pro Single submitter ⚠
- p.Ser867Arg Single submitter ⚠
- p.Ser887Thr Single submitter ⚠
- p.Ser959Asn Single submitter ⚠
- p.Thr1000Arg Single submitter ⚠
- p.Thr1000Ile Single submitter ⚠
- p.Thr1215Met Single submitter ⚠
- p.Thr1397Ala Single submitter ⚠
- p.Thr188Ala Single submitter ⚠
- p.Thr27Ala Single submitter ⚠
- p.Trp132Arg Single submitter ⚠
- p.Trp176Gly Single submitter ⚠
- p.Trp283Ser Single submitter ⚠
- p.Trp612Cys Single submitter ⚠
- p.Trp646Arg Single submitter ⚠
- p.Tyr642Cys Single submitter ⚠
- p.Tyr954Cys Single submitter ⚠
- p.Val1014Ile Single submitter ⚠
- p.Val1081Glu Single submitter ⚠
- p.Val1167Ile Single submitter ⚠
- p.Val1374Ala Single submitter ⚠
- p.Val158Met Single submitter ⚠
- p.Val25Gly Single submitter ⚠
- p.Val347Ile Single submitter ⚠
- p.Val543Ile Single submitter ⚠
- p.Val703Ile Single submitter ⚠
- p.Val711Met Single submitter ⚠
- p.Val726Ala Single submitter ⚠
- p.Val798Ile Single submitter ⚠
- p.Val960Ala Single submitter ⚠