CD164L2 — 32 ClinVar variants
All ClinVar germline CD164L2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 31 flagged for review →
32 Uncertain significance
Full CD164L2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 31
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 19
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CD164L2 p.Ala132Thr Uncertain significance Single submitter
- CD164L2 p.Ala24Val Uncertain significance Single submitter
- CD164L2 p.Ala40Ser Uncertain significance Single submitter
- CD164L2 p.Ala53Thr Uncertain significance Single submitter
- CD164L2 p.Arg43Pro Uncertain significance Single submitter
- CD164L2 p.Cys108Gly Uncertain significance Single submitter
- CD164L2 p.Cys88Arg Uncertain significance Single submitter
- CD164L2 p.Cys88Tyr Uncertain significance Single submitter
- CD164L2 p.Gln171Arg Uncertain significance Single submitter
- CD164L2 p.Gln25His Uncertain significance Single submitter
- CD164L2 p.Gly144Arg Uncertain significance Single submitter
- CD164L2 p.Gly39Val Uncertain significance Single submitter
- CD164L2 p.Gly98Asp Uncertain significance Single submitter
- CD164L2 p.His113Arg Uncertain significance Single submitter
- CD164L2 p.Leu152Pro Uncertain significance Single submitter
- CD164L2 p.Leu57Arg Uncertain significance Single submitter
- CD164L2 p.Phe162Ser Uncertain significance Single submitter
- CD164L2 p.Pro127Leu Uncertain significance Single submitter
- CD164L2 p.Val59Ala Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- CD164L2 p.Arg104Leu Uncertain significance Single submitter
- CD164L2 p.Arg10Pro Uncertain significance Single submitter
- CD164L2 p.Arg7Cys Uncertain significance Single submitter
- CD164L2 p.Glu84Lys Uncertain significance Single submitter
- CD164L2 p.His112Tyr Uncertain significance Single submitter
- CD164L2 p.His161Asp Uncertain significance Single submitter
- CD164L2 p.Leu20Pro Uncertain significance Single submitter
- CD164L2 p.Pro119Arg Uncertain significance Single submitter
- CD164L2 p.Pro82Gln Uncertain significance Single submitter
- CD164L2 p.Ser100Phe Uncertain significance Single submitter
- CD164L2 p.Thr172Ala Uncertain significance Single submitter
- CD164L2 p.Val147Met Uncertain significance Single submitter
All CD164L2 variants
Uncertain significance 32
- p.Ala132Thr Single submitter ⚠
- p.Ala24Val Single submitter ⚠
- p.Ala40Ser Single submitter ⚠
- p.Ala53Thr Single submitter ⚠
- p.Arg104Leu Single submitter ⚠
- p.Arg10Pro Single submitter ⚠
- p.Arg43Pro Single submitter ⚠
- p.Arg7Cys Single submitter ⚠
- p.Cys108Gly Single submitter ⚠
- p.Cys88Arg Single submitter ⚠
- p.Cys88Tyr Single submitter ⚠
- p.Gln171Arg Single submitter ⚠
- p.Gln25His Single submitter ⚠
- p.Glu84Lys Single submitter ⚠
- p.Gly144Arg Single submitter ⚠
- p.Gly39Val Single submitter ⚠
- p.Gly98Asp Single submitter ⚠
- p.His112Tyr Single submitter ⚠
- p.His113Arg Single submitter ⚠
- p.His161Asp Single submitter ⚠
- p.Leu152Pro Single submitter ⚠
- p.Leu20Pro Single submitter ⚠
- p.Leu57Arg Single submitter ⚠
- p.Phe162Ser Single submitter ⚠
- p.Pro119Arg Single submitter ⚠
- p.Pro127Leu Single submitter ⚠
- p.Pro82Gln Single submitter ⚠
- p.Ser100Phe Single submitter ⚠
- p.Thr172Ala Single submitter ⚠
- p.Val147Met Single submitter ⚠
- p.Val59Ala Single submitter ⚠
- p.Val76= Single submitter