CD2 — 64 ClinVar variants
All ClinVar germline CD2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 57 flagged for review →
1 Benign · 8 Likely benign · 55 Uncertain significance
Full CD2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 57
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 30
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CD2 p.Ala270Thr Uncertain significance Single submitter
- CD2 p.Ala292Ser Uncertain significance Single submitter
- CD2 p.Ala342Thr Uncertain significance Single submitter
- CD2 p.Arg129Lys Uncertain significance Single submitter
- CD2 p.Arg243Gln Uncertain significance Single submitter
- CD2 p.Arg243Leu Uncertain significance Single submitter
- CD2 p.Arg263Gln Uncertain significance Single submitter
- CD2 p.Asp55Glu Uncertain significance Single submitter
- CD2 p.Gln49Arg Uncertain significance Single submitter
- CD2 p.Glu205Gly Uncertain significance Single submitter
- CD2 p.Gly162Glu Uncertain significance Single submitter
- CD2 p.Gly340Ala Uncertain significance Single submitter
- CD2 p.His96Tyr Uncertain significance Single submitter
- CD2 p.Ile140Thr Uncertain significance Single submitter
- CD2 p.Ile172Val Uncertain significance Single submitter
- CD2 p.Ile216Val Uncertain significance Single submitter
- CD2 p.Lys25Arg Uncertain significance Single submitter
- CD2 p.Lys88Gln Uncertain significance Single submitter
- CD2 p.Lys95Glu Uncertain significance Single submitter
- CD2 p.Pro276Thr Uncertain significance Single submitter
- CD2 p.Ser108Leu Uncertain significance Single submitter
- CD2 p.Ser179Thr Uncertain significance Single submitter
- CD2 p.Ser196Thr Uncertain significance Single submitter
- CD2 p.Thr138Ile Uncertain significance Single submitter
- CD2 p.Thr83Ile Uncertain significance Single submitter
- CD2 p.Tyr211His Uncertain significance Single submitter
- CD2 p.Tyr211Ser Uncertain significance Single submitter
- CD2 p.Val117Met Uncertain significance Single submitter
- CD2 p.Val171Phe Uncertain significance Single submitter
-
CD2 p.Gly325Ala
Uncertain significance
No assertion criteria
prostate cancer
Predictors split 27
The independent predictors disagree with each other — read with care.
- CD2 p.Arg129Trp Uncertain significance Single submitter
- CD2 p.Arg296Cys Uncertain significance Single submitter
- CD2 p.Arg296His Uncertain significance Single submitter
- CD2 p.Arg303Cys Uncertain significance Single submitter
- CD2 p.Arg303His Uncertain significance Single submitter
- CD2 p.Gln102His Uncertain significance Single submitter
- CD2 p.Glu195Lys Uncertain significance Single submitter
- CD2 p.Glu26Lys Uncertain significance Single submitter
- CD2 p.Glu80Gly Uncertain significance Single submitter
- CD2 p.Gly340Trp Uncertain significance Single submitter
- CD2 p.Gly38Asp Likely benign Single submitter
- CD2 p.Ile41Leu Uncertain significance Single submitter
- CD2 p.Ile54Val Uncertain significance Single submitter
- CD2 p.Ile68Thr Uncertain significance Single submitter
- CD2 p.Ile94Met Uncertain significance Single submitter
- CD2 p.Leu222Phe Uncertain significance Single submitter
- CD2 p.Lys6Glu Uncertain significance Single submitter
- CD2 p.Pro154Leu Uncertain significance Single submitter
- CD2 p.Pro298Leu Likely benign Single submitter
- CD2 p.Pro312Thr Uncertain significance Single submitter
- CD2 p.Pro315Leu Uncertain significance Single submitter
- CD2 p.Ser347Phe Uncertain significance Single submitter
- CD2 p.Thr278Ile Uncertain significance Single submitter
- CD2 p.Thr28Met Uncertain significance Single submitter
- CD2 p.Trp34Cys Uncertain significance Single submitter
- CD2 p.Val107Leu Uncertain significance Single submitter
- CD2 p.Val231Leu Uncertain significance Single submitter
All CD2 variants
Benign 1
- p.Pro315= Single submitter
Likely benign 8
- p.Gly262Ser Single submitter
- p.Gly38Asp Single submitter ⚠
- p.Leu223Phe Single submitter
- p.Lys85Glu Single submitter
- p.Lys88Glu Single submitter
- p.Pro298Leu Single submitter ⚠
- p.Ser47Gly Single submitter
- p.Val231Ile Single submitter
Uncertain significance 55
- p.Ala270Thr Single submitter ⚠
- p.Ala292Ser Single submitter ⚠
- p.Ala342Thr Single submitter ⚠
- p.Arg129Lys Single submitter ⚠
- p.Arg129Trp Single submitter ⚠
- p.Arg243Gln Single submitter ⚠
- p.Arg243Leu Single submitter ⚠
- p.Arg263Gln Single submitter ⚠
- p.Arg296Cys Single submitter ⚠
- p.Arg296His Single submitter ⚠
- p.Arg303Cys Single submitter ⚠
- p.Arg303His Single submitter ⚠
- p.Asp55Glu Single submitter ⚠
- p.Gln102His Single submitter ⚠
- p.Gln49Arg Single submitter ⚠
- p.Glu195Lys Single submitter ⚠
- p.Glu205Gly Single submitter ⚠
- p.Glu26Lys Single submitter ⚠
- p.Glu80Gly Single submitter ⚠
- p.Gly162Glu Single submitter ⚠
- p.Gly340Ala Single submitter ⚠
- p.Gly340Trp Single submitter ⚠
- p.His96Tyr Single submitter ⚠
- p.Ile140Thr Single submitter ⚠
- p.Ile172Val Single submitter ⚠
- p.Ile216Val Single submitter ⚠
- p.Ile41Leu Single submitter ⚠
- p.Ile54Val Single submitter ⚠
- p.Ile68Thr Single submitter ⚠
- p.Ile94Met Single submitter ⚠
- p.Leu222Phe Single submitter ⚠
- p.Lys25Arg Single submitter ⚠
- p.Lys6Glu Single submitter ⚠
- p.Lys88Gln Single submitter ⚠
- p.Lys95Glu Single submitter ⚠
- p.Pro154Leu Single submitter ⚠
- p.Pro276Thr Single submitter ⚠
- p.Pro312Thr Single submitter ⚠
- p.Pro315Leu Single submitter ⚠
- p.Ser108Leu Single submitter ⚠
- p.Ser179Thr Single submitter ⚠
- p.Ser196Thr Single submitter ⚠
- p.Ser347Phe Single submitter ⚠
- p.Thr138Ile Single submitter ⚠
- p.Thr278Ile Single submitter ⚠
- p.Thr28Met Single submitter ⚠
- p.Thr83Ile Single submitter ⚠
- p.Trp34Cys Single submitter ⚠
- p.Tyr211His Single submitter ⚠
- p.Tyr211Ser Single submitter ⚠
- p.Val107Leu Single submitter ⚠
- p.Val117Met Single submitter ⚠
- p.Val171Phe Single submitter ⚠
- p.Val231Leu Single submitter ⚠
- p.Gly325Ala No assertion criteria prostate cancer ⚠