CD200R1L — 45 ClinVar variants
All ClinVar germline CD200R1L variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 43 flagged for review →
2 Likely benign · 43 Uncertain significance
Full CD200R1L gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 43
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 21
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CD200R1L c.-126G>C Uncertain significance Single submitter
- CD200R1L c.-92T>C Uncertain significance Single submitter
- CD200R1L p.Ala37Thr Uncertain significance Single submitter
- CD200R1L p.Arg208Lys Uncertain significance Single submitter
- CD200R1L p.Arg92Cys Uncertain significance Single submitter
- CD200R1L p.Gln85Arg Uncertain significance Single submitter
- CD200R1L p.Gln85Glu Uncertain significance Single submitter
- CD200R1L p.Gly181Val Uncertain significance Single submitter
- CD200R1L p.His245Arg Uncertain significance Single submitter
- CD200R1L p.Ile135Val Uncertain significance Single submitter
- CD200R1L p.Ile243Leu Uncertain significance Single submitter
- CD200R1L p.Ile36Thr Uncertain significance Single submitter
- CD200R1L p.Leu207Phe Uncertain significance Single submitter
- CD200R1L p.Leu227Val Uncertain significance Single submitter
- CD200R1L p.Lys174Asn Uncertain significance Single submitter
- CD200R1L p.Lys183Asn Uncertain significance Single submitter
- CD200R1L p.Met1Thr Uncertain significance Single submitter
- CD200R1L p.Phe228Ser Uncertain significance Single submitter
- CD200R1L p.Ser87Leu Uncertain significance Single submitter
- CD200R1L p.Thr194Ser Uncertain significance Single submitter
- CD200R1L p.Val229Met Uncertain significance Single submitter
Predictors split 22
The independent predictors disagree with each other — read with care.
- CD200R1L c.-109T>G Uncertain significance Single submitter
- CD200R1L p.Ala141Thr Uncertain significance Single submitter
- CD200R1L p.Arg115Cys Uncertain significance Single submitter
- CD200R1L p.Asp88His Uncertain significance Single submitter
- CD200R1L p.Glu66Gly Uncertain significance Single submitter
- CD200R1L p.Gly100Glu Uncertain significance Single submitter
- CD200R1L p.Gly236Arg Uncertain significance Single submitter
- CD200R1L p.Ile77Arg Uncertain significance Single submitter
- CD200R1L p.Leu193Phe Uncertain significance Single submitter
- CD200R1L p.Lys197Asn Uncertain significance Single submitter
- CD200R1L p.Phe113Cys Uncertain significance Single submitter
- CD200R1L p.Ser198Arg Uncertain significance Single submitter
- CD200R1L p.Ser212Ala Uncertain significance Single submitter
- CD200R1L p.Ser212Cys Uncertain significance Single submitter
- CD200R1L p.Thr124Ile Uncertain significance Single submitter
- CD200R1L p.Thr185Ile Uncertain significance Single submitter
- CD200R1L p.Thr57Arg Uncertain significance Single submitter
- CD200R1L p.Tyr60Cys Uncertain significance Single submitter
- CD200R1L p.Val121Met Uncertain significance Single submitter
- CD200R1L p.Val23Leu Uncertain significance Single submitter
- CD200R1L p.Val30Met Uncertain significance Single submitter
- CD200R1L p.Val94Gly Uncertain significance Single submitter
All CD200R1L variants
Likely benign 2
- p.Thr96Ile Single submitter
- p.Val201Ile Single submitter
Uncertain significance 43
- c.-109T>G Single submitter ⚠
- c.-126G>C Single submitter ⚠
- c.-92T>C Single submitter ⚠
- p.Ala141Thr Single submitter ⚠
- p.Ala37Thr Single submitter ⚠
- p.Arg115Cys Single submitter ⚠
- p.Arg208Lys Single submitter ⚠
- p.Arg92Cys Single submitter ⚠
- p.Asp88His Single submitter ⚠
- p.Gln85Arg Single submitter ⚠
- p.Gln85Glu Single submitter ⚠
- p.Glu66Gly Single submitter ⚠
- p.Gly100Glu Single submitter ⚠
- p.Gly181Val Single submitter ⚠
- p.Gly236Arg Single submitter ⚠
- p.His245Arg Single submitter ⚠
- p.Ile135Val Single submitter ⚠
- p.Ile243Leu Single submitter ⚠
- p.Ile36Thr Single submitter ⚠
- p.Ile77Arg Single submitter ⚠
- p.Leu193Phe Single submitter ⚠
- p.Leu207Phe Single submitter ⚠
- p.Leu227Val Single submitter ⚠
- p.Lys174Asn Single submitter ⚠
- p.Lys183Asn Single submitter ⚠
- p.Lys197Asn Single submitter ⚠
- p.Met1Thr Single submitter ⚠
- p.Phe113Cys Single submitter ⚠
- p.Phe228Ser Single submitter ⚠
- p.Ser198Arg Single submitter ⚠
- p.Ser212Ala Single submitter ⚠
- p.Ser212Cys Single submitter ⚠
- p.Ser87Leu Single submitter ⚠
- p.Thr124Ile Single submitter ⚠
- p.Thr185Ile Single submitter ⚠
- p.Thr194Ser Single submitter ⚠
- p.Thr57Arg Single submitter ⚠
- p.Tyr60Cys Single submitter ⚠
- p.Val121Met Single submitter ⚠
- p.Val229Met Single submitter ⚠
- p.Val23Leu Single submitter ⚠
- p.Val30Met Single submitter ⚠
- p.Val94Gly Single submitter ⚠