CD22 — 130 ClinVar variants

All ClinVar germline CD22 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 105 flagged for review →

1 Conflicting · 4 Benign · 18 Likely benign · 107 Uncertain significance

Full CD22 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 105

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 1

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

CD22 p.Arg669His Conflicting Single submitter

Predictors lean, ClinVar uncertain 85

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 19

The independent predictors disagree with each other — read with care.

All CD22 variants

Conflicting classifications of pathogenicity 1

p.Arg669His Single submitter ⚠

Benign 4

p.Ala391Thr Multiple submitters
p.Cys265= Multiple submitters
p.Gly551Arg Multiple submitters
p.Pro681= Multiple submitters

Likely benign 18

p.Gly727Ser Multiple submitters
c.2209-8C>T Single submitter
p.Ala461Thr Single submitter
p.Ala798Val Single submitter
p.Arg711= Single submitter
p.Cys39= Single submitter
p.Gln152Arg Single submitter
p.Glu266Lys Single submitter
p.Leu692Val Single submitter
p.Lys66Gln Single submitter
p.Met600Ile Single submitter
p.Met783Thr Single submitter
p.Pro317Ser Single submitter
p.Ser190Leu Single submitter
p.Ser625Tyr Single submitter
p.Ser780= Single submitter
p.Ser79Asn Single submitter
p.Val315Leu Single submitter

Uncertain significance 107

p.Ala17Val Single submitter ⚠
p.Ala498Ser Single submitter ⚠
p.Ala656Thr Single submitter ⚠
p.Ala702Thr Single submitter ⚠
p.Arg407Lys Single submitter ⚠
p.Arg453Gln Single submitter ⚠
p.Arg511Gln Single submitter ⚠
p.Arg548Gly Single submitter ⚠
p.Arg548Met Single submitter ⚠
p.Arg597Cys Single submitter ⚠
p.Arg597His Single submitter ⚠
p.Arg774Pro Single submitter ⚠
p.Arg802Cys Single submitter ⚠
p.Arg802His Single submitter ⚠
p.Asn358Lys Single submitter ⚠
p.Asn358Ser Single submitter ⚠
p.Asn428Ile Single submitter ⚠
p.Asn621Ser Single submitter ⚠
p.Asp259Gly Single submitter ⚠
p.Asp302Asn Single submitter ⚠
p.Asp302Tyr Single submitter ⚠
p.Asp50Glu Single submitter ⚠
p.Asp559His Single submitter ⚠
p.Asp619Asn Single submitter ⚠
p.Asp792Asn Single submitter ⚠
p.Asp806Asn Single submitter ⚠
p.Asp97Tyr Single submitter ⚠
p.Cys219Phe Single submitter ⚠
p.Cys704Tyr Single submitter ⚠
p.Gln328His Single submitter ⚠
p.Gln528Arg Single submitter ⚠
p.Gln605Lys Single submitter ⚠
p.Gln660Arg Single submitter ⚠
p.Gln728His Single submitter ⚠
p.Gln784Arg Single submitter ⚠
p.Gln784His Single submitter ⚠
p.Glu130Lys Single submitter ⚠
p.Glu298Lys Single submitter ⚠
p.Glu518Lys Single submitter ⚠
p.Glu682Asp Single submitter ⚠
p.Glu744Gln Single submitter ⚠
p.Glu818Lys Single submitter ⚠
p.Gly318Arg Single submitter ⚠
p.Gly410Arg Single submitter ⚠
p.Gly468Arg Single submitter ⚠
p.Gly551Glu Single submitter ⚠
p.Gly5Ser Single submitter ⚠
p.Gly655Cys Single submitter ⚠
p.Gly666Ser Single submitter ⚠
p.Gly819Arg Single submitter ⚠
p.Gly829Ala Single submitter ⚠
p.Gly831Arg Single submitter ⚠
p.Gly96Glu Single submitter ⚠
p.His520Pro Single submitter ⚠
p.His626Tyr Single submitter ⚠
p.His747Tyr Single submitter ⚠
p.Ile132fs Single submitter
p.Ile145Val Single submitter ⚠
p.Leu11Pro Single submitter ⚠
p.Leu296Gln Single submitter ⚠
p.Leu352Phe Single submitter ⚠
p.Leu387Phe Single submitter ⚠
p.Leu550Pro Single submitter ⚠
p.Lys100Thr Single submitter ⚠
p.Lys205Gln Single submitter ⚠
p.Lys243Asn Single submitter ⚠
p.Lys385Glu Single submitter ⚠
p.Lys735Glu Single submitter ⚠
p.Lys846Arg Single submitter ⚠
p.Met373Ile Single submitter ⚠
p.Phe531Leu Single submitter ⚠
p.Pro149Ser Single submitter ⚠
p.Pro171Leu Single submitter ⚠
p.Pro317Leu Single submitter ⚠
p.Pro342Leu Single submitter ⚠
p.Pro429Ala Single submitter ⚠
p.Pro431Leu Single submitter ⚠
p.Pro602Leu Single submitter ⚠
p.Pro648Leu Single submitter ⚠
p.Pro812Thr Single submitter ⚠
p.Pro815Ser Single submitter ⚠
p.Ser202Arg Single submitter ⚠
p.Ser202Asn Single submitter
p.Ser260Pro Single submitter ⚠
p.Ser304Asn Single submitter ⚠
p.Ser562Cys Single submitter ⚠
p.Ser618Ile Single submitter ⚠
p.Ser69Leu Single submitter ⚠
p.Thr189Ala Single submitter ⚠
p.Thr189Pro Single submitter ⚠
p.Thr31Ile Single submitter ⚠
p.Thr404Ser Single submitter ⚠
p.Thr45Ile Single submitter ⚠
p.Thr715Ser Single submitter ⚠
p.Thr793Met Single submitter ⚠
p.Trp210Arg Single submitter ⚠
p.Trp477Arg Single submitter ⚠
p.Trp543Ser Single submitter ⚠
p.Trp585Arg Single submitter ⚠
p.Tyr364His Single submitter ⚠
p.Tyr46Cys Single submitter
p.Val12Ala Single submitter ⚠
p.Val217Met Single submitter ⚠
p.Val234Leu Single submitter ⚠
p.Val267Ile Single submitter ⚠
p.Val323Met Single submitter ⚠
p.Val92Met Single submitter ⚠