CD226 — 54 ClinVar variants
All ClinVar germline CD226 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 48 flagged for review →
7 Likely benign · 47 Uncertain significance
Full CD226 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 48
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 33
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CD226 p.Ala133Val Uncertain significance Single submitter
- CD226 p.Ala16Gly Uncertain significance Single submitter
- CD226 p.Ala226Thr Uncertain significance Single submitter
- CD226 p.Ala76Thr Uncertain significance Single submitter
- CD226 p.Ala76Val Uncertain significance Single submitter
- CD226 p.Asn298Ser Uncertain significance Single submitter
- CD226 p.Asn299Asp Uncertain significance Single submitter
- CD226 p.Asp246Asn Uncertain significance Single submitter
- CD226 p.Gln115Lys Uncertain significance Single submitter
- CD226 p.Gln153Arg Uncertain significance Single submitter
- CD226 p.Glu19Lys Uncertain significance Single submitter
- CD226 p.Glu319Gly Uncertain significance Single submitter
- CD226 p.Gly116Arg Uncertain significance Single submitter
- CD226 p.Gly54Arg Uncertain significance Single submitter
- CD226 p.His183Arg Uncertain significance Single submitter
- CD226 p.Ile140Met Uncertain significance Single submitter
- CD226 p.Ile140Val Uncertain significance Single submitter
- CD226 p.Ile304Val Uncertain significance Single submitter
- CD226 p.Lys146Arg Uncertain significance Single submitter
- CD226 p.Lys244Arg Uncertain significance Single submitter
- CD226 p.Met86Thr Uncertain significance Single submitter
- CD226 p.Pro170Leu Uncertain significance Single submitter
- CD226 p.Thr112Ser Uncertain significance Single submitter
- CD226 p.Thr117Ile Uncertain significance Single submitter
- CD226 p.Thr213Arg Uncertain significance Single submitter
- CD226 p.Thr250Ser Uncertain significance Single submitter
- CD226 p.Thr317Lys Uncertain significance Single submitter
- CD226 p.Thr85Met Uncertain significance Single submitter
- CD226 p.Trp50Arg Uncertain significance Single submitter
- CD226 p.Tyr106Ser Uncertain significance Single submitter
- CD226 p.Val103Ile Uncertain significance Single submitter
- CD226 p.Val163Leu Uncertain significance Single submitter
- CD226 p.Val206Ile Uncertain significance Single submitter
Predictors split 15
The independent predictors disagree with each other — read with care.
- CD226 p.Ala9Pro Uncertain significance Single submitter
- CD226 p.Arg193Gly Uncertain significance Single submitter
- CD226 p.Asn198Thr Uncertain significance Single submitter
- CD226 p.His12Arg Uncertain significance Single submitter
- CD226 p.Leu7Phe Uncertain significance Single submitter
- CD226 p.Leu82Phe Uncertain significance Single submitter
- CD226 p.Phe63Cys Uncertain significance Single submitter
- CD226 p.Pro144Leu Uncertain significance Single submitter
- CD226 p.Pro210Arg Uncertain significance Single submitter
- CD226 p.Ser142Leu Uncertain significance Single submitter
- CD226 p.Ser227Ile Uncertain significance Single submitter
- CD226 p.Thr151Ile Uncertain significance Single submitter
- CD226 p.Thr25Ile Uncertain significance Single submitter
- CD226 p.Tyr223Cys Likely benign Single submitter
- CD226 p.Val79Ala Uncertain significance Single submitter
All CD226 variants
Likely benign 7
- p.Arg185Lys Single submitter
- p.Arg283Lys Single submitter
- p.Asp211Asn Single submitter
- p.Glu31Lys Single submitter
- p.Ile44Thr Single submitter
- p.Tyr223Cys Single submitter ⚠
- p.Val208Ile Single submitter
Uncertain significance 47
- p.Ala133Val Single submitter ⚠
- p.Ala16Gly Single submitter ⚠
- p.Ala226Thr Single submitter ⚠
- p.Ala76Thr Single submitter ⚠
- p.Ala76Val Single submitter ⚠
- p.Ala9Pro Single submitter ⚠
- p.Arg193Gly Single submitter ⚠
- p.Asn198Thr Single submitter ⚠
- p.Asn298Ser Single submitter ⚠
- p.Asn299Asp Single submitter ⚠
- p.Asp246Asn Single submitter ⚠
- p.Gln115Lys Single submitter ⚠
- p.Gln153Arg Single submitter ⚠
- p.Glu19Lys Single submitter ⚠
- p.Glu319Gly Single submitter ⚠
- p.Gly116Arg Single submitter ⚠
- p.Gly54Arg Single submitter ⚠
- p.His12Arg Single submitter ⚠
- p.His183Arg Single submitter ⚠
- p.Ile140Met Single submitter ⚠
- p.Ile140Val Single submitter ⚠
- p.Ile304Val Single submitter ⚠
- p.Leu7Phe Single submitter ⚠
- p.Leu82Phe Single submitter ⚠
- p.Lys146Arg Single submitter ⚠
- p.Lys244Arg Single submitter ⚠
- p.Met86Thr Single submitter ⚠
- p.Phe63Cys Single submitter ⚠
- p.Pro144Leu Single submitter ⚠
- p.Pro170Leu Single submitter ⚠
- p.Pro210Arg Single submitter ⚠
- p.Ser142Leu Single submitter ⚠
- p.Ser227Ile Single submitter ⚠
- p.Thr112Ser Single submitter ⚠
- p.Thr117Ile Single submitter ⚠
- p.Thr151Ile Single submitter ⚠
- p.Thr213Arg Single submitter ⚠
- p.Thr250Ser Single submitter ⚠
- p.Thr25Ile Single submitter ⚠
- p.Thr317Lys Single submitter ⚠
- p.Thr85Met Single submitter ⚠
- p.Trp50Arg Single submitter ⚠
- p.Tyr106Ser Single submitter ⚠
- p.Val103Ile Single submitter ⚠
- p.Val163Leu Single submitter ⚠
- p.Val206Ile Single submitter ⚠
- p.Val79Ala Single submitter ⚠