CD244 — 52 ClinVar variants
All ClinVar germline CD244 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 40 flagged for review →
4 Benign · 10 Likely benign · 38 Uncertain significance
Full CD244 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 40
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 22
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CD244 c.380-3C>T Uncertain significance Single submitter
- CD244 c.380-4C>T Uncertain significance Single submitter
- CD244 p.Ala234Ser Uncertain significance Single submitter
- CD244 p.Arg355His Uncertain significance Single submitter
- CD244 p.Asn349Lys Uncertain significance Single submitter
- CD244 p.Asn80Asp Uncertain significance Single submitter
- CD244 p.Cys152Phe Uncertain significance Single submitter
- CD244 p.Cys194Tyr Uncertain significance Single submitter
- CD244 p.Gln137Lys Uncertain significance Single submitter
- CD244 p.Gln40Glu Uncertain significance Single submitter
- CD244 p.Gln40Lys Uncertain significance Single submitter
- CD244 p.His217Gln Uncertain significance Single submitter
- CD244 p.Ile86Val Uncertain significance Single submitter
- CD244 p.Phe220Leu Uncertain significance Single submitter
- CD244 p.Phe236Ser Uncertain significance Single submitter
- CD244 p.Phe83Tyr Uncertain significance Single submitter
- CD244 p.Pro285Leu Uncertain significance Single submitter
- CD244 p.Pro302Thr Uncertain significance Single submitter
- CD244 p.Pro350Ser Uncertain significance Single submitter
- CD244 p.Pro36Ser Uncertain significance Single submitter
- CD244 p.Ser168Thr Uncertain significance Single submitter
-
CD244 p.Arg324Lys
Uncertain significance
No assertion criteria
prostate cancer
Predictors split 18
The independent predictors disagree with each other — read with care.
- CD244 p.Arg133Cys Uncertain significance Single submitter
- CD244 p.Asn360Lys Uncertain significance Single submitter
- CD244 p.Asp268His Uncertain significance Single submitter
- CD244 p.Gly19Asp Uncertain significance Single submitter
- CD244 p.Ile340Thr Uncertain significance Single submitter
- CD244 p.Ile44Met Uncertain significance Single submitter
- CD244 p.Leu207Pro Uncertain significance Single submitter
- CD244 p.Leu90Trp Uncertain significance Single submitter
- CD244 p.Lys139Asn Uncertain significance Single submitter
- CD244 p.Pro307Arg Uncertain significance Single submitter
- CD244 p.Ser155Phe Uncertain significance Single submitter
- CD244 p.Ser31Asn Uncertain significance Single submitter
- CD244 p.Ser323Tyr Uncertain significance Single submitter
- CD244 p.Thr206Asn Uncertain significance Single submitter
- CD244 p.Thr303Met Uncertain significance Single submitter
- CD244 p.Val154Asp Uncertain significance Single submitter
- CD244 p.Val184Ile Likely benign Single submitter
-
CD244 p.Arg355Cys
Benign
No assertion criteria
CD244-related disorder
All CD244 variants
Benign 4
- c.*578T>C Multiple submitters
- p.Ile229Val Multiple submitters
- p.Leu13= Multiple submitters
- p.Arg355Cys No assertion criteria CD244-related disorder ⚠
Likely benign 10
- p.Asp127His Single submitter
- p.Gln218His Single submitter
- p.His65Gln Single submitter
- p.Ile265Val Single submitter
- p.Pro75Thr Single submitter
- p.Ser204Asn Single submitter
- p.Ser33Leu Single submitter
- p.Thr118Arg Single submitter
- p.Tyr179His Single submitter
- p.Val184Ile Single submitter ⚠
Uncertain significance 38
- c.380-3C>T Single submitter ⚠
- c.380-4C>T Single submitter ⚠
- p.Ala234Ser Single submitter ⚠
- p.Arg133Cys Single submitter ⚠
- p.Arg355His Single submitter ⚠
- p.Asn349Lys Single submitter ⚠
- p.Asn360Lys Single submitter ⚠
- p.Asn80Asp Single submitter ⚠
- p.Asp268His Single submitter ⚠
- p.Cys152Phe Single submitter ⚠
- p.Cys194Tyr Single submitter ⚠
- p.Gln137Lys Single submitter ⚠
- p.Gln40Glu Single submitter ⚠
- p.Gln40Lys Single submitter ⚠
- p.Gly19Asp Single submitter ⚠
- p.His217Gln Single submitter ⚠
- p.Ile340Thr Single submitter ⚠
- p.Ile44Met Single submitter ⚠
- p.Ile86Val Single submitter ⚠
- p.Leu207Pro Single submitter ⚠
- p.Leu90Trp Single submitter ⚠
- p.Lys139Asn Single submitter ⚠
- p.Phe220Leu Single submitter ⚠
- p.Phe236Ser Single submitter ⚠
- p.Phe83Tyr Single submitter ⚠
- p.Pro285Leu Single submitter ⚠
- p.Pro302Thr Single submitter ⚠
- p.Pro307Arg Single submitter ⚠
- p.Pro350Ser Single submitter ⚠
- p.Pro36Ser Single submitter ⚠
- p.Ser155Phe Single submitter ⚠
- p.Ser168Thr Single submitter ⚠
- p.Ser31Asn Single submitter ⚠
- p.Ser323Tyr Single submitter ⚠
- p.Thr206Asn Single submitter ⚠
- p.Thr303Met Single submitter ⚠
- p.Val154Asp Single submitter ⚠
- p.Arg324Lys No assertion criteria prostate cancer ⚠