CD274 — 16 ClinVar variants
All ClinVar germline CD274 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 11 flagged for review →
4 Benign · 2 Likely benign · 10 Uncertain significance
Full CD274 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 11
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 6
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CD274 p.Arg186Ser Uncertain significance Single submitter
- CD274 p.Asn183Thr Uncertain significance Single submitter
- CD274 p.Asn278His Uncertain significance Single submitter
- CD274 p.Glu205Asp Uncertain significance Single submitter
- CD274 p.Met115Val Uncertain significance Single submitter
- CD274 p.Thr277Ala Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All CD274 variants
Benign 4
- c.*2635A>G Multiple submitters
- c.*93G>A Multiple submitters
- p.Ala121= Single submitter
- p.Gln66= Single submitter
Likely benign 2
- p.Pro146Arg Single submitter
- p.Val21Ile Single submitter ⚠
Uncertain significance 10
- p.Arg186Ser Single submitter ⚠
- p.Asn183Thr Single submitter ⚠
- p.Asn278His Single submitter ⚠
- p.Glu205Asp Single submitter ⚠
- p.Glu217Lys Single submitter ⚠
- p.Met115Val Single submitter ⚠
- p.Pro146Thr Single submitter ⚠
- p.Ser176Cys Single submitter ⚠
- p.Thr182Ile Single submitter ⚠
- p.Thr277Ala Single submitter ⚠