CD300A — 51 ClinVar variants
All ClinVar germline CD300A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 44 flagged for review →
8 Likely benign · 43 Uncertain significance
Full CD300A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 44
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 21
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CD300A p.Ala6Thr Uncertain significance Single submitter
- CD300A p.Arg262Gly Uncertain significance Single submitter
- CD300A p.Arg285Pro Uncertain significance Single submitter
- CD300A p.Cys103Tyr Uncertain significance Single submitter
- CD300A p.Cys15Tyr Uncertain significance Single submitter
- CD300A p.Glu173Asp Uncertain significance Single submitter
- CD300A p.Ile136Thr Uncertain significance Single submitter
- CD300A p.Ile279Leu Uncertain significance Single submitter
- CD300A p.Ile279Thr Uncertain significance Single submitter
- CD300A p.Leu18Val Uncertain significance Single submitter
- CD300A p.Lys244Asn Uncertain significance Single submitter
- CD300A p.Met131Val Uncertain significance Single submitter
- CD300A p.Met203Val Uncertain significance Single submitter
- CD300A p.Pro108Leu Uncertain significance Single submitter
- CD300A p.Pro126Gln Uncertain significance Single submitter
- CD300A p.Pro247Leu Uncertain significance Single submitter
- CD300A p.Pro284Ser Uncertain significance Single submitter
- CD300A p.Ser142Thr Uncertain significance Single submitter
- CD300A p.Thr143Ala Uncertain significance Single submitter
- CD300A p.Tyr38Cys Uncertain significance Single submitter
- CD300A p.Val159Ala Uncertain significance Single submitter
Predictors split 23
The independent predictors disagree with each other — read with care.
- CD300A p.Ala98Gly Uncertain significance Single submitter
- CD300A p.Asn176Tyr Uncertain significance Single submitter
- CD300A p.Glu63Asp Uncertain significance Single submitter
- CD300A p.Gly14Glu Uncertain significance Single submitter
- CD300A p.Gly30Arg Uncertain significance Single submitter
- CD300A p.Gly66Val Uncertain significance Single submitter
- CD300A p.His230Arg Uncertain significance Single submitter
- CD300A p.His266Tyr Uncertain significance Single submitter
- CD300A p.His42Gln Uncertain significance Single submitter
- CD300A p.Leu3Gln Uncertain significance Single submitter
- CD300A p.Pro133Leu Uncertain significance Single submitter
- CD300A p.Pro13Ala Uncertain significance Single submitter
- CD300A p.Ser269Leu Uncertain significance Single submitter
- CD300A p.Ser269Pro Uncertain significance Single submitter
- CD300A p.Thr129Met Uncertain significance Single submitter
- CD300A p.Thr143Arg Uncertain significance Single submitter
- CD300A p.Thr145Arg Uncertain significance Single submitter
- CD300A p.Trp2Cys Uncertain significance Single submitter
- CD300A p.Trp5Cys Uncertain significance Single submitter
- CD300A p.Val117Ile Likely benign Single submitter
- CD300A p.Val120Ala Uncertain significance Single submitter
- CD300A p.Val24Met Uncertain significance Single submitter
- CD300A p.Val253Leu Uncertain significance Single submitter
All CD300A variants
Likely benign 8
- p.Arg285Gln Single submitter
- p.Glu287Lys Single submitter
- p.His42Tyr Single submitter
- p.Phe113Leu Single submitter
- p.Thr225= Single submitter
- p.Thr23= Single submitter
- p.Trp207Arg Single submitter
- p.Val117Ile Single submitter ⚠
Uncertain significance 43
- p.Ala6Thr Single submitter ⚠
- p.Ala98Gly Single submitter ⚠
- p.Arg262Gly Single submitter ⚠
- p.Arg285Pro Single submitter ⚠
- p.Asn176Tyr Single submitter ⚠
- p.Cys103Tyr Single submitter ⚠
- p.Cys15Tyr Single submitter ⚠
- p.Glu173Asp Single submitter ⚠
- p.Glu63Asp Single submitter ⚠
- p.Gly14Glu Single submitter ⚠
- p.Gly30Arg Single submitter ⚠
- p.Gly66Val Single submitter ⚠
- p.His230Arg Single submitter ⚠
- p.His266Tyr Single submitter ⚠
- p.His42Gln Single submitter ⚠
- p.Ile136Thr Single submitter ⚠
- p.Ile279Leu Single submitter ⚠
- p.Ile279Thr Single submitter ⚠
- p.Leu18Val Single submitter ⚠
- p.Leu3Gln Single submitter ⚠
- p.Lys244Asn Single submitter ⚠
- p.Met131Val Single submitter ⚠
- p.Met203Val Single submitter ⚠
- p.Pro108Leu Single submitter ⚠
- p.Pro126Gln Single submitter ⚠
- p.Pro133Leu Single submitter ⚠
- p.Pro13Ala Single submitter ⚠
- p.Pro247Leu Single submitter ⚠
- p.Pro284Ser Single submitter ⚠
- p.Ser142Thr Single submitter ⚠
- p.Ser269Leu Single submitter ⚠
- p.Ser269Pro Single submitter ⚠
- p.Thr129Met Single submitter ⚠
- p.Thr143Ala Single submitter ⚠
- p.Thr143Arg Single submitter ⚠
- p.Thr145Arg Single submitter ⚠
- p.Trp2Cys Single submitter ⚠
- p.Trp5Cys Single submitter ⚠
- p.Tyr38Cys Single submitter ⚠
- p.Val120Ala Single submitter ⚠
- p.Val159Ala Single submitter ⚠
- p.Val24Met Single submitter ⚠
- p.Val253Leu Single submitter ⚠