CD300C — 46 ClinVar variants
All ClinVar germline CD300C variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 42 flagged for review →
4 Likely benign · 42 Uncertain significance
Full CD300C gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 42
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 22
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CD300C p.Ala13Gly Uncertain significance Single submitter
- CD300C p.Ala89Thr Uncertain significance Single submitter
- CD300C p.Arg210Ser Uncertain significance Single submitter
- CD300C p.Arg44His Uncertain significance Single submitter
- CD300C p.Arg44Pro Uncertain significance Single submitter
- CD300C p.Glu126Lys Uncertain significance Single submitter
- CD300C p.Glu170Lys Uncertain significance Single submitter
- CD300C p.Gly135Arg Uncertain significance Single submitter
- CD300C p.Gly135Glu Uncertain significance Single submitter
- CD300C p.Gly150Ala Uncertain significance Single submitter
- CD300C p.Gly73Glu Uncertain significance Single submitter
- CD300C p.His158Leu Uncertain significance Single submitter
- CD300C p.Ile62Ser Uncertain significance Single submitter
- CD300C p.Ile84Leu Uncertain significance Single submitter
- CD300C p.Phe179Ile Uncertain significance Single submitter
- CD300C p.Phe93Leu Uncertain significance Single submitter
- CD300C p.Pro115Leu Uncertain significance Single submitter
- CD300C p.Pro133Leu Uncertain significance Single submitter
- CD300C p.Pro59Gln Uncertain significance Single submitter
- CD300C p.Ser172Arg Uncertain significance Single submitter
- CD300C p.Ser180Thr Uncertain significance Single submitter
- CD300C p.Ser8Leu Uncertain significance Single submitter
Predictors split 20
The independent predictors disagree with each other — read with care.
- CD300C p.Ala89Val Uncertain significance Single submitter
- CD300C p.Glu98Asp Uncertain significance Single submitter
- CD300C p.Ile68Thr Uncertain significance Single submitter
- CD300C p.Leu186Phe Uncertain significance Single submitter
- CD300C p.Pro24Leu Uncertain significance Single submitter
- CD300C p.Ser197Thr Uncertain significance Single submitter
- CD300C p.Ser40Gly Uncertain significance Single submitter
- CD300C p.Thr107Ala Uncertain significance Single submitter
- CD300C p.Thr107Ile Uncertain significance Single submitter
- CD300C p.Thr136Met Uncertain significance Single submitter
- CD300C p.Thr153Met Uncertain significance Single submitter
- CD300C p.Thr164Ile Uncertain significance Single submitter
- CD300C p.Trp109Arg Uncertain significance Single submitter
- CD300C p.Val127Ala Uncertain significance Single submitter
- CD300C p.Val129Glu Uncertain significance Single submitter
- CD300C p.Val129Leu Uncertain significance Single submitter
- CD300C p.Val131Met Uncertain significance Single submitter
- CD300C p.Val157Met Uncertain significance Single submitter
- CD300C p.Val19Ala Uncertain significance Single submitter
- CD300C p.Val35Met Uncertain significance Single submitter
All CD300C variants
Likely benign 4
- p.Arg118Gln Single submitter
- p.Arg183His Single submitter
- p.Glu126Gln Single submitter
- p.Val202Ile Single submitter
Uncertain significance 42
- p.Ala13Gly Single submitter ⚠
- p.Ala89Thr Single submitter ⚠
- p.Ala89Val Single submitter ⚠
- p.Arg210Ser Single submitter ⚠
- p.Arg44His Single submitter ⚠
- p.Arg44Pro Single submitter ⚠
- p.Glu126Lys Single submitter ⚠
- p.Glu170Lys Single submitter ⚠
- p.Glu98Asp Single submitter ⚠
- p.Gly135Arg Single submitter ⚠
- p.Gly135Glu Single submitter ⚠
- p.Gly150Ala Single submitter ⚠
- p.Gly73Glu Single submitter ⚠
- p.His158Leu Single submitter ⚠
- p.Ile62Ser Single submitter ⚠
- p.Ile68Thr Single submitter ⚠
- p.Ile84Leu Single submitter ⚠
- p.Leu186Phe Single submitter ⚠
- p.Phe179Ile Single submitter ⚠
- p.Phe93Leu Single submitter ⚠
- p.Pro115Leu Single submitter ⚠
- p.Pro133Leu Single submitter ⚠
- p.Pro24Leu Single submitter ⚠
- p.Pro59Gln Single submitter ⚠
- p.Ser172Arg Single submitter ⚠
- p.Ser180Thr Single submitter ⚠
- p.Ser197Thr Single submitter ⚠
- p.Ser40Gly Single submitter ⚠
- p.Ser8Leu Single submitter ⚠
- p.Thr107Ala Single submitter ⚠
- p.Thr107Ile Single submitter ⚠
- p.Thr136Met Single submitter ⚠
- p.Thr153Met Single submitter ⚠
- p.Thr164Ile Single submitter ⚠
- p.Trp109Arg Single submitter ⚠
- p.Val127Ala Single submitter ⚠
- p.Val129Glu Single submitter ⚠
- p.Val129Leu Single submitter ⚠
- p.Val131Met Single submitter ⚠
- p.Val157Met Single submitter ⚠
- p.Val19Ala Single submitter ⚠
- p.Val35Met Single submitter ⚠