CD300LB — 34 ClinVar variants
All ClinVar germline CD300LB variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 23 flagged for review →
8 Likely benign · 26 Uncertain significance
Full CD300LB gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 23
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 9
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CD300LB p.Ala26Ser Uncertain significance Single submitter
- CD300LB p.Arg177Gly Uncertain significance Single submitter
- CD300LB p.Asn136Asp Uncertain significance Single submitter
- CD300LB p.Glu180Val Uncertain significance Single submitter
- CD300LB p.Pro186Ser Uncertain significance Single submitter
- CD300LB p.Ser137Asn Uncertain significance Single submitter
- CD300LB p.Ser67Leu Uncertain significance Single submitter
- CD300LB p.Thr196Ile Uncertain significance Single submitter
- CD300LB p.Trp42Arg Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- CD300LB p.Ala26Val Uncertain significance Single submitter
- CD300LB p.Arg25Thr Uncertain significance Single submitter
- CD300LB p.Arg51Gln Uncertain significance Single submitter
- CD300LB p.Arg54Cys Uncertain significance Single submitter
- CD300LB p.Arg54His Uncertain significance Single submitter
- CD300LB p.Asn81Lys Uncertain significance Single submitter
- CD300LB p.Glu28Lys Uncertain significance Single submitter
- CD300LB p.Gly20Asp Uncertain significance Single submitter
- CD300LB p.Gly30Trp Uncertain significance Single submitter
- CD300LB p.Ile62Leu Uncertain significance Single submitter
- CD300LB p.Leu113Phe Uncertain significance Single submitter
- CD300LB p.Leu12Phe Uncertain significance Single submitter
- CD300LB p.Lys173Glu Uncertain significance Single submitter
- CD300LB p.Lys47Arg Uncertain significance Single submitter
All CD300LB variants
Likely benign 8
- c.-27C>T Single submitter
- p.Arg96Gln Single submitter
- p.Gly144Ser Single submitter
- p.His146Tyr Single submitter
- p.Leu170= Single submitter
- p.Ser192= Single submitter
- p.Val121Ile Single submitter
- p.Val53Ala Single submitter
Uncertain significance 26
- c.-14G>T Single submitter
- c.-42T>A Single submitter
- c.-59G>T Single submitter
- p.Ala26Ser Single submitter ⚠
- p.Ala26Val Single submitter ⚠
- p.Arg177Gly Single submitter ⚠
- p.Arg25Thr Single submitter ⚠
- p.Arg51Gln Single submitter ⚠
- p.Arg54Cys Single submitter ⚠
- p.Arg54His Single submitter ⚠
- p.Asn136Asp Single submitter ⚠
- p.Asn81Lys Single submitter ⚠
- p.Glu180Val Single submitter ⚠
- p.Glu28Lys Single submitter ⚠
- p.Gly20Asp Single submitter ⚠
- p.Gly30Trp Single submitter ⚠
- p.Ile62Leu Single submitter ⚠
- p.Leu113Phe Single submitter ⚠
- p.Leu12Phe Single submitter ⚠
- p.Lys173Glu Single submitter ⚠
- p.Lys47Arg Single submitter ⚠
- p.Pro186Ser Single submitter ⚠
- p.Ser137Asn Single submitter ⚠
- p.Ser67Leu Single submitter ⚠
- p.Thr196Ile Single submitter ⚠
- p.Trp42Arg Single submitter ⚠