CD300LD — 32 ClinVar variants
All ClinVar germline CD300LD variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 30 flagged for review →
3 Likely benign · 29 Uncertain significance
Full CD300LD gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 30
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 13
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CD300LD p.Ala148Val Uncertain significance Single submitter
- CD300LD p.Ala18Val Uncertain significance Single submitter
- CD300LD p.Ala56Gly Uncertain significance Single submitter
- CD300LD p.Ala56Thr Uncertain significance Single submitter
- CD300LD p.Arg193Lys Uncertain significance Single submitter
- CD300LD p.Arg52Gln Uncertain significance Single submitter
- CD300LD p.Asp57Asn Uncertain significance Single submitter
- CD300LD p.Glu134Gly Uncertain significance Single submitter
- CD300LD p.Lys119Arg Uncertain significance Single submitter
- CD300LD p.Lys76Asn Uncertain significance Single submitter
- CD300LD p.Met180Ile Uncertain significance Single submitter
- CD300LD p.Ser163Asn Uncertain significance Single submitter
- CD300LD p.Thr152Ala Uncertain significance Single submitter
Predictors split 17
The independent predictors disagree with each other — read with care.
- CD300LD p.Cys107Arg Uncertain significance Single submitter
- CD300LD p.Glu31Gly Uncertain significance Single submitter
- CD300LD p.Gly127Asp Likely benign Single submitter
- CD300LD p.Gly29Ala Uncertain significance Single submitter
- CD300LD p.Gly33Ser Uncertain significance Single submitter
- CD300LD p.Met94Val Uncertain significance Single submitter
- CD300LD p.Pro13Ser Uncertain significance Single submitter
- CD300LD p.Pro190Thr Uncertain significance Single submitter
- CD300LD p.Ser154Asn Uncertain significance Single submitter
- CD300LD p.Ser194Phe Uncertain significance Single submitter
- CD300LD p.Thr123Pro Uncertain significance Single submitter
- CD300LD p.Thr137Asn Uncertain significance Single submitter
- CD300LD p.Thr47Ile Uncertain significance Single submitter
- CD300LD p.Tyr41Cys Uncertain significance Single submitter
- CD300LD p.Val184Ile Uncertain significance Single submitter
- CD300LD p.Val37Met Uncertain significance Single submitter
- CD300LD p.Val92Met Uncertain significance Single submitter
All CD300LD variants
Likely benign 3
- p.Ala19Thr Single submitter
- p.Glu95= Single submitter
- p.Gly127Asp Single submitter ⚠
Uncertain significance 29
- p.Ala148Val Single submitter ⚠
- p.Ala18Val Single submitter ⚠
- p.Ala56Gly Single submitter ⚠
- p.Ala56Thr Single submitter ⚠
- p.Arg193Lys Single submitter ⚠
- p.Arg52Gln Single submitter ⚠
- p.Asp57Asn Single submitter ⚠
- p.Cys107Arg Single submitter ⚠
- p.Glu134Gly Single submitter ⚠
- p.Glu31Gly Single submitter ⚠
- p.Gly29Ala Single submitter ⚠
- p.Gly33Ser Single submitter ⚠
- p.Lys119Arg Single submitter ⚠
- p.Lys76Asn Single submitter ⚠
- p.Met180Ile Single submitter ⚠
- p.Met94Val Single submitter ⚠
- p.Pro13Ser Single submitter ⚠
- p.Pro190Thr Single submitter ⚠
- p.Ser154Asn Single submitter ⚠
- p.Ser163Asn Single submitter ⚠
- p.Ser194Phe Single submitter ⚠
- p.Thr123Pro Single submitter ⚠
- p.Thr137Asn Single submitter ⚠
- p.Thr152Ala Single submitter ⚠
- p.Thr47Ile Single submitter ⚠
- p.Tyr41Cys Single submitter ⚠
- p.Val184Ile Single submitter ⚠
- p.Val37Met Single submitter ⚠
- p.Val92Met Single submitter ⚠