CD300LF — 41 ClinVar variants
All ClinVar germline CD300LF variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 32 flagged for review →
8 Likely benign · 33 Uncertain significance
Full CD300LF gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 32
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 25
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CD300LF p.Arg55Gln Uncertain significance Single submitter
- CD300LF p.Asn88Thr Uncertain significance Single submitter
- CD300LF p.Asp102Glu Uncertain significance Single submitter
- CD300LF p.Asp202Asn Uncertain significance Single submitter
- CD300LF p.Cys108Tyr Uncertain significance Single submitter
- CD300LF p.Gln132Arg Uncertain significance Single submitter
- CD300LF p.Glu72Gln Uncertain significance Single submitter
- CD300LF p.His150Tyr Uncertain significance Single submitter
- CD300LF p.Ile18Thr Uncertain significance Single submitter
- CD300LF p.Ile58Leu Uncertain significance Single submitter
- CD300LF p.Leu254Phe Uncertain significance Single submitter
- CD300LF p.Leu273Pro Uncertain significance Single submitter
- CD300LF p.Lys154Arg Uncertain significance Single submitter
- CD300LF p.Lys154Gln Uncertain significance Single submitter
- CD300LF p.Pro139Gln Uncertain significance Single submitter
- CD300LF p.Pro198His Uncertain significance Single submitter
- CD300LF p.Pro217Thr Uncertain significance Single submitter
- CD300LF p.Pro281Leu Uncertain significance Single submitter
- CD300LF p.Ser35Phe Uncertain significance Single submitter
- CD300LF p.Ser44Leu Uncertain significance Single submitter
- CD300LF p.Thr222Met Uncertain significance Single submitter
- CD300LF p.Thr37Ile Uncertain significance Single submitter
- CD300LF p.Thr90Met Uncertain significance Single submitter
- CD300LF p.Tyr249Cys Uncertain significance Single submitter
- CD300LF p.Val171Met Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- CD300LF p.Ala103Val Uncertain significance Single submitter
- CD300LF p.Arg79Gln Uncertain significance Single submitter
- CD300LF p.Arg79Pro Uncertain significance Single submitter
- CD300LF p.Arg79Trp Uncertain significance Single submitter
- CD300LF p.Arg89Cys Uncertain significance Single submitter
- CD300LF p.Gly24Ser Uncertain significance Single submitter
- CD300LF p.Pro25Ser Uncertain significance Single submitter
All CD300LF variants
Likely benign 8
- p.Arg60His Single submitter
- p.Asp97Glu Single submitter
- p.Gly143Ser Single submitter
- p.Gly275Ser Single submitter
- p.Lys100Arg Single submitter
- p.Lys151Asn Single submitter
- p.Lys83Arg Single submitter
- p.Thr90= Single submitter
Uncertain significance 33
- p.Ala103Val Single submitter ⚠
- p.Arg55Gln Single submitter ⚠
- p.Arg55Gly Single submitter
- p.Arg79Gln Single submitter ⚠
- p.Arg79Pro Single submitter ⚠
- p.Arg79Trp Single submitter ⚠
- p.Arg89Cys Single submitter ⚠
- p.Asn88Thr Single submitter ⚠
- p.Asp102Glu Single submitter ⚠
- p.Asp202Asn Single submitter ⚠
- p.Cys108Tyr Single submitter ⚠
- p.Gln132Arg Single submitter ⚠
- p.Glu72Gln Single submitter ⚠
- p.Gly24Ser Single submitter ⚠
- p.His150Tyr Single submitter ⚠
- p.Ile18Thr Single submitter ⚠
- p.Ile58Leu Single submitter ⚠
- p.Leu254Phe Single submitter ⚠
- p.Leu273Pro Single submitter ⚠
- p.Lys154Arg Single submitter ⚠
- p.Lys154Gln Single submitter ⚠
- p.Pro139Gln Single submitter ⚠
- p.Pro198His Single submitter ⚠
- p.Pro217Thr Single submitter ⚠
- p.Pro25Ser Single submitter ⚠
- p.Pro281Leu Single submitter ⚠
- p.Ser35Phe Single submitter ⚠
- p.Ser44Leu Single submitter ⚠
- p.Thr222Met Single submitter ⚠
- p.Thr37Ile Single submitter ⚠
- p.Thr90Met Single submitter ⚠
- p.Tyr249Cys Single submitter ⚠
- p.Val171Met Single submitter ⚠