CD34 — 51 ClinVar variants
All ClinVar germline CD34 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 46 flagged for review →
5 Likely benign · 46 Uncertain significance
Full CD34 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 46
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 31
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CD34 p.Ala222Val Uncertain significance Single submitter
- CD34 p.Ala224Asp Uncertain significance Single submitter
- CD34 p.Ala234Thr Uncertain significance Single submitter
- CD34 p.Ala349Thr Uncertain significance Single submitter
- CD34 p.Arg314His Uncertain significance Single submitter
- CD34 p.Arg323Lys Uncertain significance Single submitter
- CD34 p.Asn85Ser Uncertain significance Single submitter
- CD34 p.Cys242Ser Uncertain significance Single submitter
- CD34 p.Glu218Asp Uncertain significance Single submitter
- CD34 p.Glu218Lys Uncertain significance Single submitter
- CD34 p.Gly325Asp Uncertain significance Single submitter
- CD34 p.Gly334Ser Uncertain significance Single submitter
- CD34 p.Gly344Ala Uncertain significance Single submitter
- CD34 p.Gly351Glu Uncertain significance Single submitter
- CD34 p.Gly365Arg Uncertain significance Single submitter
- CD34 p.Gly47Arg Uncertain significance Single submitter
- CD34 p.Ile86Leu Uncertain significance Single submitter
- CD34 p.Ile86Met Uncertain significance Single submitter
- CD34 p.Leu67Val Uncertain significance Single submitter
- CD34 p.Lys135Asn Uncertain significance Single submitter
- CD34 p.Pro160Ser Uncertain significance Single submitter
- CD34 p.Pro166Ser Uncertain significance Single submitter
- CD34 p.Ser265Pro Uncertain significance Single submitter
- CD34 p.Ser354Arg Uncertain significance Single submitter
- CD34 p.Ser354Ile Uncertain significance Single submitter
- CD34 p.Ser69Asn Uncertain significance Single submitter
- CD34 p.Thr18Pro Uncertain significance Single submitter
- CD34 p.Thr320Ser Uncertain significance Single submitter
- CD34 p.Val110Leu Uncertain significance Single submitter
- CD34 p.Val379Leu Uncertain significance Single submitter
- CD34 p.Val380Met Uncertain significance Single submitter
Predictors split 15
The independent predictors disagree with each other — read with care.
- CD34 p.Arg315His Uncertain significance Single submitter
- CD34 p.Asn333His Uncertain significance Single submitter
- CD34 p.Asn362Lys Uncertain significance Single submitter
- CD34 p.Asn51Asp Uncertain significance Single submitter
- CD34 p.Cys21Gly Uncertain significance Single submitter
- CD34 p.Gly365Asp Uncertain significance Single submitter
- CD34 p.Leu22Trp Uncertain significance Single submitter
- CD34 p.Leu25Ser Uncertain significance Single submitter
- CD34 p.Met260Arg Uncertain significance Single submitter
- CD34 p.Pro343His Uncertain significance Single submitter
- CD34 p.Ser118Asn Uncertain significance Single submitter
- CD34 p.Ser95Ala Uncertain significance Single submitter
- CD34 p.Thr114Ile Uncertain significance Single submitter
- CD34 p.Thr162Ala Uncertain significance Single submitter
- CD34 p.Val355Met Uncertain significance Single submitter
All CD34 variants
Likely benign 5
- p.Val127Ile Multiple submitters
- p.Ala82Thr Single submitter
- p.Asn80Ser Single submitter
- p.Glu217Lys Single submitter
- p.Gly37Ser Single submitter
Uncertain significance 46
- p.Ala222Val Single submitter ⚠
- p.Ala224Asp Single submitter ⚠
- p.Ala234Thr Single submitter ⚠
- p.Ala349Thr Single submitter ⚠
- p.Arg314His Single submitter ⚠
- p.Arg315His Single submitter ⚠
- p.Arg323Lys Single submitter ⚠
- p.Asn333His Single submitter ⚠
- p.Asn362Lys Single submitter ⚠
- p.Asn51Asp Single submitter ⚠
- p.Asn85Ser Single submitter ⚠
- p.Cys21Gly Single submitter ⚠
- p.Cys242Ser Single submitter ⚠
- p.Glu218Asp Single submitter ⚠
- p.Glu218Lys Single submitter ⚠
- p.Gly325Asp Single submitter ⚠
- p.Gly334Ser Single submitter ⚠
- p.Gly344Ala Single submitter ⚠
- p.Gly351Glu Single submitter ⚠
- p.Gly365Arg Single submitter ⚠
- p.Gly365Asp Single submitter ⚠
- p.Gly47Arg Single submitter ⚠
- p.Ile86Leu Single submitter ⚠
- p.Ile86Met Single submitter ⚠
- p.Leu22Trp Single submitter ⚠
- p.Leu25Ser Single submitter ⚠
- p.Leu67Val Single submitter ⚠
- p.Lys135Asn Single submitter ⚠
- p.Met260Arg Single submitter ⚠
- p.Pro160Ser Single submitter ⚠
- p.Pro166Ser Single submitter ⚠
- p.Pro343His Single submitter ⚠
- p.Ser118Asn Single submitter ⚠
- p.Ser265Pro Single submitter ⚠
- p.Ser354Arg Single submitter ⚠
- p.Ser354Ile Single submitter ⚠
- p.Ser69Asn Single submitter ⚠
- p.Ser95Ala Single submitter ⚠
- p.Thr114Ile Single submitter ⚠
- p.Thr162Ala Single submitter ⚠
- p.Thr18Pro Single submitter ⚠
- p.Thr320Ser Single submitter ⚠
- p.Val110Leu Single submitter ⚠
- p.Val355Met Single submitter ⚠
- p.Val379Leu Single submitter ⚠
- p.Val380Met Single submitter ⚠