CD37 — 40 ClinVar variants
All ClinVar germline CD37 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 35 flagged for review →
3 Benign · 2 Likely benign · 35 Uncertain significance
Full CD37 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 35
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 21
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CD37 p.Arg112Gly Uncertain significance Single submitter
- CD37 p.Arg112Pro Uncertain significance Single submitter
- CD37 p.Arg281Ser Uncertain significance Single submitter
- CD37 p.Asn275Lys Uncertain significance Single submitter
- CD37 p.Gln232Lys Uncertain significance Single submitter
- CD37 p.Glu124Lys Uncertain significance Single submitter
- CD37 p.Gly169Asp Uncertain significance Single submitter
- CD37 p.His272Tyr Uncertain significance Single submitter
- CD37 p.Ile108Thr Uncertain significance Single submitter
- CD37 p.Ile216Thr Uncertain significance Single submitter
- CD37 p.Ile36Asn Uncertain significance Single submitter
- CD37 p.Leu28Pro Uncertain significance Single submitter
- CD37 p.Leu49Phe Uncertain significance Single submitter
- CD37 p.Lys195Met Uncertain significance Single submitter
- CD37 p.Lys40Glu Uncertain significance Single submitter
- CD37 p.Phe148Ser Uncertain significance Single submitter
- CD37 p.Ser118Thr Uncertain significance Single submitter
- CD37 p.Ser58Tyr Uncertain significance Single submitter
- CD37 p.Ser6Asn Uncertain significance Single submitter
- CD37 p.Thr100Ile Uncertain significance Single submitter
- CD37 p.Val164Ala Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- CD37 p.Ala221Thr Uncertain significance Single submitter
- CD37 p.Arg120Leu Uncertain significance Single submitter
- CD37 p.Arg281Cys Uncertain significance Single submitter
- CD37 p.Asn170Asp Uncertain significance Single submitter
- CD37 p.Gly171Trp Uncertain significance Single submitter
- CD37 p.Gly233Asp Uncertain significance Single submitter
- CD37 p.Gly247Val Uncertain significance Single submitter
- CD37 p.Gly33Ser Uncertain significance Single submitter
- CD37 p.Ile225Val Uncertain significance Single submitter
- CD37 p.Ile243Thr Uncertain significance Single submitter
- CD37 p.Ile245Thr Uncertain significance Single submitter
- CD37 p.Val123Leu Uncertain significance Single submitter
- CD37 p.Val44Met Uncertain significance Single submitter
- CD37 p.Val77Met Uncertain significance Single submitter
All CD37 variants
Benign 3
- p.Val44= Multiple submitters
- c.685-7C>T Single submitter
- p.Val122Ile Single submitter
Likely benign 2
- p.Asp121Glu Single submitter
- p.Ser213Asn Single submitter
Uncertain significance 35
- p.Ala221Thr Single submitter ⚠
- p.Arg112Gly Single submitter ⚠
- p.Arg112Pro Single submitter ⚠
- p.Arg120Leu Single submitter ⚠
- p.Arg281Cys Single submitter ⚠
- p.Arg281Ser Single submitter ⚠
- p.Asn170Asp Single submitter ⚠
- p.Asn275Lys Single submitter ⚠
- p.Gln232Lys Single submitter ⚠
- p.Glu124Lys Single submitter ⚠
- p.Gly169Asp Single submitter ⚠
- p.Gly171Trp Single submitter ⚠
- p.Gly233Asp Single submitter ⚠
- p.Gly247Val Single submitter ⚠
- p.Gly33Ser Single submitter ⚠
- p.His272Tyr Single submitter ⚠
- p.Ile108Thr Single submitter ⚠
- p.Ile216Thr Single submitter ⚠
- p.Ile225Val Single submitter ⚠
- p.Ile243Thr Single submitter ⚠
- p.Ile245Thr Single submitter ⚠
- p.Ile36Asn Single submitter ⚠
- p.Leu28Pro Single submitter ⚠
- p.Leu49Phe Single submitter ⚠
- p.Lys195Met Single submitter ⚠
- p.Lys40Glu Single submitter ⚠
- p.Phe148Ser Single submitter ⚠
- p.Ser118Thr Single submitter ⚠
- p.Ser58Tyr Single submitter ⚠
- p.Ser6Asn Single submitter ⚠
- p.Thr100Ile Single submitter ⚠
- p.Val123Leu Single submitter ⚠
- p.Val164Ala Single submitter ⚠
- p.Val44Met Single submitter ⚠
- p.Val77Met Single submitter ⚠