CD47 — 24 ClinVar variants
All ClinVar germline CD47 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 23 flagged for review →
24 Uncertain significance
Full CD47 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 23
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 12
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CD47 p.Ala178Gly Uncertain significance Single submitter
- CD47 p.Ala281Thr Uncertain significance Single submitter
- CD47 p.Asp104Asn Uncertain significance Single submitter
- CD47 p.Ile150Val Uncertain significance Single submitter
- CD47 p.Ile153Val Uncertain significance Single submitter
- CD47 p.Ile244Thr Uncertain significance Single submitter
- CD47 p.Met319Val Uncertain significance Single submitter
- CD47 p.Pro269Ala Uncertain significance Single submitter
- CD47 p.Thr25Ser Uncertain significance Single submitter
- CD47 p.Thr31Met Uncertain significance Single submitter
- CD47 p.Val238Ile Uncertain significance Single submitter
- CD47 p.Val88Ala Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- CD47 p.Glu128Lys Uncertain significance Single submitter
- CD47 p.Gly318Ala Uncertain significance Single submitter
- CD47 p.Ile127Leu Uncertain significance Single submitter
- CD47 p.Ile195Leu Uncertain significance Single submitter
- CD47 p.Ile221Met Uncertain significance Single submitter
- CD47 p.Ile241Met Uncertain significance Single submitter
- CD47 p.Lys85Asn Uncertain significance Single submitter
- CD47 p.Met319Arg Uncertain significance Single submitter
- CD47 p.Ser257Asn Uncertain significance Single submitter
- CD47 p.Ser316Leu Uncertain significance Single submitter
- CD47 p.Tyr249Cys Uncertain significance Single submitter
All CD47 variants
Uncertain significance 24
- p.Ala178Gly Single submitter ⚠
- p.Ala281Thr Single submitter ⚠
- p.Asp104Asn Single submitter ⚠
- p.Glu128Lys Single submitter ⚠
- p.Gly318Ala Single submitter ⚠
- p.Ile127Leu Single submitter ⚠
- p.Ile150Val Single submitter ⚠
- p.Ile153Val Single submitter ⚠
- p.Ile195Leu Single submitter ⚠
- p.Ile221Met Single submitter ⚠
- p.Ile241Met Single submitter ⚠
- p.Ile244Thr Single submitter ⚠
- p.Lys85Asn Single submitter ⚠
- p.Met319Arg Single submitter ⚠
- p.Met319Val Single submitter ⚠
- p.Pro269Ala Single submitter ⚠
- p.Ser257Asn Single submitter ⚠
- p.Ser316Leu Single submitter ⚠
- p.Thr25Ser Single submitter ⚠
- p.Thr31Met Single submitter ⚠
- p.Trp2Ter Single submitter
- p.Tyr249Cys Single submitter ⚠
- p.Val238Ile Single submitter ⚠
- p.Val88Ala Single submitter ⚠