CD5 — 63 ClinVar variants
All ClinVar germline CD5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 57 flagged for review →
2 Benign · 4 Likely benign · 57 Uncertain significance
Full CD5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 57
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 34
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CD5 p.Ala295Ser Uncertain significance Single submitter
- CD5 p.Ala492Asp Uncertain significance Single submitter
- CD5 p.Ala492Val Uncertain significance Single submitter
- CD5 p.Arg228Gln Uncertain significance Single submitter
- CD5 p.Arg39His Uncertain significance Single submitter
- CD5 p.Arg431His Uncertain significance Single submitter
- CD5 p.Arg83Trp Uncertain significance Single submitter
- CD5 p.Asn443Ile Uncertain significance Single submitter
- CD5 p.Gln160Arg Uncertain significance Single submitter
- CD5 p.Glu175Lys Uncertain significance Single submitter
- CD5 p.Glu469Lys Uncertain significance Single submitter
- CD5 p.Gly166Asp Uncertain significance Single submitter
- CD5 p.Gly219Arg Uncertain significance Single submitter
- CD5 p.Gly55Arg Uncertain significance Single submitter
- CD5 p.Gly65Asp Uncertain significance Single submitter
- CD5 p.His351Tyr Uncertain significance Single submitter
- CD5 p.His473Arg Uncertain significance Single submitter
- CD5 p.Ile185Val Uncertain significance Single submitter
- CD5 p.Ile235Thr Uncertain significance Single submitter
- CD5 p.Leu330Arg Uncertain significance Single submitter
- CD5 p.Leu385Val Uncertain significance Single submitter
- CD5 p.Leu390Val Uncertain significance Single submitter
- CD5 p.Leu9Val Uncertain significance Single submitter
- CD5 p.Lys413Gln Uncertain significance Single submitter
- CD5 p.Met58Lys Uncertain significance Single submitter
- CD5 p.Pro101Ala Uncertain significance Single submitter
- CD5 p.Pro101Ser Uncertain significance Single submitter
- CD5 p.Thr434Met Uncertain significance Single submitter
- CD5 p.Thr445Ile Uncertain significance Single submitter
- CD5 p.Tyr465His Uncertain significance Single submitter
- CD5 p.Val173Met Uncertain significance Single submitter
- CD5 p.Val396Met Uncertain significance Single submitter
- CD5 p.Val437Ile Uncertain significance Single submitter
- CD5 p.Val449Met Uncertain significance Single submitter
Predictors split 23
The independent predictors disagree with each other — read with care.
- CD5 p.Ala77Val Uncertain significance Single submitter
- CD5 p.Arg338Gln Uncertain significance Single submitter
- CD5 p.Arg39Cys Uncertain significance Single submitter
- CD5 p.Arg415His Uncertain significance Single submitter
- CD5 p.Arg431Cys Uncertain significance Single submitter
- CD5 p.Asn241Lys Uncertain significance Single submitter
- CD5 p.Asp484Asn Uncertain significance Single submitter
- CD5 p.Glu290Lys Uncertain significance Single submitter
- CD5 p.Gly281Asp Uncertain significance Single submitter
- CD5 p.Gly398Ser Uncertain significance Single submitter
- CD5 p.Leu130Arg Uncertain significance Single submitter
- CD5 p.Leu265Val Uncertain significance Single submitter
- CD5 p.Lys403Met Uncertain significance Single submitter
- CD5 p.Phe176Leu Uncertain significance Single submitter
- CD5 p.Pro146Leu Uncertain significance Single submitter
- CD5 p.Pro370Ala Uncertain significance Single submitter
- CD5 p.Pro456Ser Uncertain significance Single submitter
- CD5 p.Ser268Leu Uncertain significance Single submitter
- CD5 p.Ser283Thr Uncertain significance Single submitter
- CD5 p.Ser42Leu Uncertain significance Single submitter
- CD5 p.Ser68Ala Uncertain significance Single submitter
- CD5 p.Thr149Lys Uncertain significance Single submitter
- CD5 p.Val289Met Uncertain significance Single submitter
All CD5 variants
Benign 2
- p.Ala471Val Multiple submitters
- p.Pro224Leu Multiple submitters
Likely benign 4
- p.Arg328Gln Single submitter
- p.Ile106Thr Single submitter
- p.Ser103Asn Single submitter
- p.Val173= Single submitter
Uncertain significance 57
- p.Ala295Ser Single submitter ⚠
- p.Ala492Asp Single submitter ⚠
- p.Ala492Val Single submitter ⚠
- p.Ala77Val Single submitter ⚠
- p.Arg228Gln Single submitter ⚠
- p.Arg338Gln Single submitter ⚠
- p.Arg39Cys Single submitter ⚠
- p.Arg39His Single submitter ⚠
- p.Arg415His Single submitter ⚠
- p.Arg431Cys Single submitter ⚠
- p.Arg431His Single submitter ⚠
- p.Arg83Trp Single submitter ⚠
- p.Asn241Lys Single submitter ⚠
- p.Asn443Ile Single submitter ⚠
- p.Asp484Asn Single submitter ⚠
- p.Gln160Arg Single submitter ⚠
- p.Glu175Lys Single submitter ⚠
- p.Glu290Lys Single submitter ⚠
- p.Glu469Lys Single submitter ⚠
- p.Gly166Asp Single submitter ⚠
- p.Gly219Arg Single submitter ⚠
- p.Gly281Asp Single submitter ⚠
- p.Gly398Ser Single submitter ⚠
- p.Gly55Arg Single submitter ⚠
- p.Gly65Asp Single submitter ⚠
- p.His351Tyr Single submitter ⚠
- p.His473Arg Single submitter ⚠
- p.Ile185Val Single submitter ⚠
- p.Ile235Thr Single submitter ⚠
- p.Leu130Arg Single submitter ⚠
- p.Leu265Val Single submitter ⚠
- p.Leu330Arg Single submitter ⚠
- p.Leu385Val Single submitter ⚠
- p.Leu390Val Single submitter ⚠
- p.Leu9Val Single submitter ⚠
- p.Lys403Met Single submitter ⚠
- p.Lys413Gln Single submitter ⚠
- p.Met58Lys Single submitter ⚠
- p.Phe176Leu Single submitter ⚠
- p.Pro101Ala Single submitter ⚠
- p.Pro101Ser Single submitter ⚠
- p.Pro146Leu Single submitter ⚠
- p.Pro370Ala Single submitter ⚠
- p.Pro456Ser Single submitter ⚠
- p.Ser268Leu Single submitter ⚠
- p.Ser283Thr Single submitter ⚠
- p.Ser42Leu Single submitter ⚠
- p.Ser68Ala Single submitter ⚠
- p.Thr149Lys Single submitter ⚠
- p.Thr434Met Single submitter ⚠
- p.Thr445Ile Single submitter ⚠
- p.Tyr465His Single submitter ⚠
- p.Val173Met Single submitter ⚠
- p.Val289Met Single submitter ⚠
- p.Val396Met Single submitter ⚠
- p.Val437Ile Single submitter ⚠
- p.Val449Met Single submitter ⚠