CD58 — 31 ClinVar variants
All ClinVar germline CD58 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 25 flagged for review →
1 Benign · 6 Likely benign · 24 Uncertain significance
Full CD58 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 25
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 12
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CD58 p.Arg246Gly Uncertain significance Single submitter
- CD58 p.Asn179Asp Uncertain significance Single submitter
- CD58 p.Asn48Asp Uncertain significance Single submitter
- CD58 p.Gly24Val Uncertain significance Single submitter
- CD58 p.His211Asn Uncertain significance Single submitter
- CD58 p.Ile110Val Uncertain significance Single submitter
- CD58 p.Met105Val Uncertain significance Single submitter
- CD58 p.Met163Val Uncertain significance Single submitter
- CD58 p.Ser209Asn Uncertain significance Single submitter
- CD58 p.Ser249Ala Uncertain significance Single submitter
- CD58 p.Val45Leu Uncertain significance Single submitter
- CD58 p.Val86Glu Uncertain significance Single submitter
Predictors split 13
The independent predictors disagree with each other — read with care.
- CD58 p.Ala224Ser Uncertain significance Single submitter
- CD58 p.Ala7Glu Uncertain significance Single submitter
- CD58 p.Arg168Pro Uncertain significance Single submitter
- CD58 p.Asn135Thr Uncertain significance Single submitter
- CD58 p.Cys229Tyr Uncertain significance Single submitter
- CD58 p.Gln31His Uncertain significance Single submitter
- CD58 p.Phe77Leu Uncertain significance Single submitter
- CD58 p.Pro182Ser Likely benign Single submitter
- CD58 p.Ser107Leu Uncertain significance Single submitter
- CD58 p.Ser172Gly Uncertain significance Single submitter
- CD58 p.Tyr216Cys Uncertain significance Single submitter
- CD58 p.Tyr34Cys Uncertain significance Single submitter
- CD58 p.Val63Ala Uncertain significance Single submitter
All CD58 variants
Benign 1
- c.70+12568T>C Single submitter
Likely benign 6
- p.Asn250Ser Single submitter
- p.His214Gln Single submitter
- p.Ile206Val Single submitter
- p.Leu189Val Single submitter
- p.Pro182Ser Single submitter ⚠
- p.Thr227Ile Single submitter
Uncertain significance 24
- p.Ala224Ser Single submitter ⚠
- p.Ala7Glu Single submitter ⚠
- p.Arg168Pro Single submitter ⚠
- p.Arg246Gly Single submitter ⚠
- p.Asn135Thr Single submitter ⚠
- p.Asn179Asp Single submitter ⚠
- p.Asn48Asp Single submitter ⚠
- p.Cys229Tyr Single submitter ⚠
- p.Gln31His Single submitter ⚠
- p.Gly24Val Single submitter ⚠
- p.His211Asn Single submitter ⚠
- p.Ile110Val Single submitter ⚠
- p.Met105Val Single submitter ⚠
- p.Met163Val Single submitter ⚠
- p.Phe77Leu Single submitter ⚠
- p.Ser107Leu Single submitter ⚠
- p.Ser172Gly Single submitter ⚠
- p.Ser209Asn Single submitter ⚠
- p.Ser249Ala Single submitter ⚠
- p.Tyr216Cys Single submitter ⚠
- p.Tyr34Cys Single submitter ⚠
- p.Val45Leu Single submitter ⚠
- p.Val63Ala Single submitter ⚠
- p.Val86Glu Single submitter ⚠