CD5L — 46 ClinVar variants
All ClinVar germline CD5L variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 44 flagged for review →
2 Likely benign · 44 Uncertain significance
Full CD5L gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 44
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 24
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CD5L p.Ala172Ser Uncertain significance Single submitter
- CD5L p.Ala342Ser Uncertain significance Single submitter
- CD5L p.Arg198Leu Uncertain significance Single submitter
- CD5L p.Asn272Ser Uncertain significance Single submitter
- CD5L p.Cys191Arg Uncertain significance Single submitter
- CD5L p.Gln178Glu Uncertain significance Single submitter
- CD5L p.Gln205Arg Uncertain significance Single submitter
- CD5L p.Gln324Lys Uncertain significance Single submitter
- CD5L p.Glu109Gln Uncertain significance Single submitter
- CD5L p.Glu237Lys Uncertain significance Single submitter
- CD5L p.Glu84Gln Uncertain significance Single submitter
- CD5L p.Gly210Ala Uncertain significance Single submitter
- CD5L p.Gly266Asp Uncertain significance Single submitter
- CD5L p.Gly304Val Uncertain significance Single submitter
- CD5L p.Gly72Arg Uncertain significance Single submitter
- CD5L p.His194Gln Uncertain significance Single submitter
- CD5L p.Lys262Glu Uncertain significance Single submitter
- CD5L p.Phe5Val Uncertain significance Single submitter
- CD5L p.Pro293Ser Uncertain significance Single submitter
- CD5L p.Ser129Arg Uncertain significance Single submitter
- CD5L p.Thr99Lys Uncertain significance Single submitter
- CD5L p.Tyr160Phe Uncertain significance Single submitter
- CD5L p.Val162Glu Uncertain significance Single submitter
- CD5L p.Val305Ile Uncertain significance Single submitter
Predictors split 20
The independent predictors disagree with each other — read with care.
- CD5L p.Ala59Val Uncertain significance Single submitter
- CD5L p.Arg150Leu Uncertain significance Single submitter
- CD5L p.Arg328Ile Uncertain significance Single submitter
- CD5L p.Asn272Thr Uncertain significance Single submitter
- CD5L p.Asp54Tyr Uncertain significance Single submitter
- CD5L p.Gln87Arg Uncertain significance Single submitter
- CD5L p.Glu239Asp Uncertain significance Single submitter
- CD5L p.Glu318Gly Uncertain significance Single submitter
- CD5L p.Glu40Asp Uncertain significance Single submitter
- CD5L p.Gly46Ala Uncertain significance Single submitter
- CD5L p.Ile8Asn Uncertain significance Single submitter
- CD5L p.Leu291Phe Uncertain significance Single submitter
- CD5L p.Leu4Ile Uncertain significance Single submitter
- CD5L p.Pro81Ala Uncertain significance Single submitter
- CD5L p.Ser204Arg Uncertain significance Single submitter
- CD5L p.Ser267Ala Uncertain significance Single submitter
- CD5L p.Ser290Tyr Uncertain significance Single submitter
- CD5L p.Thr161Ala Uncertain significance Single submitter
- CD5L p.Tyr79Cys Uncertain significance Single submitter
- CD5L p.Val39Met Uncertain significance Single submitter
All CD5L variants
Likely benign 2
- p.Arg170Gln Single submitter
- p.Glu318Lys Single submitter
Uncertain significance 44
- p.Ala172Ser Single submitter ⚠
- p.Ala342Ser Single submitter ⚠
- p.Ala59Val Single submitter ⚠
- p.Arg150Leu Single submitter ⚠
- p.Arg198Leu Single submitter ⚠
- p.Arg328Ile Single submitter ⚠
- p.Asn272Ser Single submitter ⚠
- p.Asn272Thr Single submitter ⚠
- p.Asp54Tyr Single submitter ⚠
- p.Cys191Arg Single submitter ⚠
- p.Gln178Glu Single submitter ⚠
- p.Gln205Arg Single submitter ⚠
- p.Gln324Lys Single submitter ⚠
- p.Gln87Arg Single submitter ⚠
- p.Glu109Gln Single submitter ⚠
- p.Glu237Lys Single submitter ⚠
- p.Glu239Asp Single submitter ⚠
- p.Glu318Gly Single submitter ⚠
- p.Glu40Asp Single submitter ⚠
- p.Glu84Gln Single submitter ⚠
- p.Gly210Ala Single submitter ⚠
- p.Gly266Asp Single submitter ⚠
- p.Gly304Val Single submitter ⚠
- p.Gly46Ala Single submitter ⚠
- p.Gly72Arg Single submitter ⚠
- p.His194Gln Single submitter ⚠
- p.Ile8Asn Single submitter ⚠
- p.Leu291Phe Single submitter ⚠
- p.Leu4Ile Single submitter ⚠
- p.Lys262Glu Single submitter ⚠
- p.Phe5Val Single submitter ⚠
- p.Pro293Ser Single submitter ⚠
- p.Pro81Ala Single submitter ⚠
- p.Ser129Arg Single submitter ⚠
- p.Ser204Arg Single submitter ⚠
- p.Ser267Ala Single submitter ⚠
- p.Ser290Tyr Single submitter ⚠
- p.Thr161Ala Single submitter ⚠
- p.Thr99Lys Single submitter ⚠
- p.Tyr160Phe Single submitter ⚠
- p.Tyr79Cys Single submitter ⚠
- p.Val162Glu Single submitter ⚠
- p.Val305Ile Single submitter ⚠
- p.Val39Met Single submitter ⚠