CD68 — 69 ClinVar variants
All ClinVar germline CD68 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 61 flagged for review →
3 Benign · 6 Likely benign · 60 Uncertain significance
Full CD68 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 61
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 22
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CD68 p.Ala10Val Uncertain significance Single submitter
- CD68 p.Ala262Thr Uncertain significance Single submitter
- CD68 p.Ala299Asp Uncertain significance Single submitter
- CD68 p.Ala99Thr Uncertain significance Single submitter
- CD68 p.Cys24Tyr Uncertain significance Single submitter
- CD68 p.Gly68Ser Uncertain significance Single submitter
- CD68 p.His289Gln Uncertain significance Single submitter
- CD68 p.Ile157Thr Uncertain significance Single submitter
- CD68 p.Leu196Pro Uncertain significance Single submitter
- CD68 p.Lys27Glu Uncertain significance Single submitter
- CD68 p.Met241Val Uncertain significance Single submitter
- CD68 p.Phe218Leu Uncertain significance Single submitter
- CD68 p.Phe227Tyr Uncertain significance Single submitter
- CD68 p.Pro40Ser Uncertain significance Single submitter
- CD68 p.Pro74Ser Uncertain significance Single submitter
- CD68 p.Ser150Gly Uncertain significance Single submitter
- CD68 p.Ser8Ala Uncertain significance Single submitter
- CD68 p.Thr161Lys Uncertain significance Single submitter
- CD68 p.Thr163Asn Uncertain significance Single submitter
- CD68 p.Thr184Ala Uncertain significance Single submitter
- CD68 p.Thr69Ala Uncertain significance Single submitter
- CD68 p.Tyr240Asp Uncertain significance Single submitter
Predictors split 39
The independent predictors disagree with each other — read with care.
- CD68 p.Ala269Val Uncertain significance Single submitter
- CD68 p.Arg345Pro Uncertain significance Single submitter
- CD68 p.Arg345Trp Uncertain significance Single submitter
- CD68 p.Arg346Gly Uncertain significance Single submitter
- CD68 p.Arg347Cys Uncertain significance Single submitter
- CD68 p.Gln18Arg Uncertain significance Single submitter
- CD68 p.Gln273Leu Uncertain significance Single submitter
- CD68 p.Gly117Arg Uncertain significance Single submitter
- CD68 p.Gly133Glu Uncertain significance Single submitter
- CD68 p.Gly13Trp Uncertain significance Single submitter
- CD68 p.Gly332Ser Uncertain significance Single submitter
- CD68 p.His62Arg Uncertain significance Single submitter
- CD68 p.His72Asp Uncertain significance Single submitter
- CD68 p.Ile282Thr Uncertain significance Single submitter
- CD68 p.Leu295Val Uncertain significance Single submitter
- CD68 p.Pro212Leu Uncertain significance Single submitter
- CD68 p.Pro74Ala Uncertain significance Single submitter
- CD68 p.Ser115Arg Uncertain significance Single submitter
- CD68 p.Ser148Asn Uncertain significance Single submitter
- CD68 p.Ser258Leu Uncertain significance Single submitter
- CD68 p.Ser281Asn Uncertain significance Single submitter
- CD68 p.Ser85Arg Uncertain significance Single submitter
- CD68 p.Ser97Asn Uncertain significance Single submitter
- CD68 p.Thr100Ser Uncertain significance Single submitter
- CD68 p.Thr114Ile Uncertain significance Single submitter
- CD68 p.Thr128Ser Uncertain significance Single submitter
- CD68 p.Thr184Ile Uncertain significance Single submitter
- CD68 p.Thr37Met Uncertain significance Single submitter
- CD68 p.Thr41Met Benign Single submitter
- CD68 p.Thr59Ile Uncertain significance Single submitter
- CD68 p.Thr59Ser Uncertain significance Single submitter
- CD68 p.Thr75Met Uncertain significance Single submitter
- CD68 p.Thr83Ile Uncertain significance Single submitter
- CD68 p.Thr84Ile Uncertain significance Single submitter
- CD68 p.Thr84Ser Uncertain significance Single submitter
- CD68 p.Trp255Cys Uncertain significance Single submitter
- CD68 p.Tyr220Cys Uncertain significance Single submitter
- CD68 p.Tyr237Asn Uncertain significance Single submitter
- CD68 p.Val121Ile Uncertain significance Single submitter
All CD68 variants
Benign 3
- p.Ile329Thr Multiple submitters
- p.Gln18= Single submitter
- p.Thr41Met Single submitter ⚠
Likely benign 6
- c.931+9T>C Single submitter
- p.Arg296Lys Single submitter
- p.Gly9= Single submitter
- p.Leu214= Single submitter
- p.Ser8Leu Single submitter
- p.Thr183= Single submitter
Uncertain significance 60
- p.Ala10Val Single submitter ⚠
- p.Ala262Thr Single submitter ⚠
- p.Ala269Val Single submitter ⚠
- p.Ala299Asp Single submitter ⚠
- p.Ala99Thr Single submitter ⚠
- p.Arg345Pro Single submitter ⚠
- p.Arg345Trp Single submitter ⚠
- p.Arg346Gly Single submitter ⚠
- p.Arg347Cys Single submitter ⚠
- p.Cys24Tyr Single submitter ⚠
- p.Gln18Arg Single submitter ⚠
- p.Gln273Leu Single submitter ⚠
- p.Gly117Arg Single submitter ⚠
- p.Gly133Glu Single submitter ⚠
- p.Gly13Trp Single submitter ⚠
- p.Gly332Ser Single submitter ⚠
- p.Gly68Ser Single submitter ⚠
- p.His289Gln Single submitter ⚠
- p.His62Arg Single submitter ⚠
- p.His72Asp Single submitter ⚠
- p.Ile157Thr Single submitter ⚠
- p.Ile282Thr Single submitter ⚠
- p.Leu196Pro Single submitter ⚠
- p.Leu295Val Single submitter ⚠
- p.Lys27Glu Single submitter ⚠
- p.Met241Val Single submitter ⚠
- p.Phe218Leu Single submitter ⚠
- p.Phe227Tyr Single submitter ⚠
- p.Pro212Leu Single submitter ⚠
- p.Pro40Ser Single submitter ⚠
- p.Pro74Ala Single submitter ⚠
- p.Pro74Ser Single submitter ⚠
- p.Ser115Arg Single submitter ⚠
- p.Ser148Asn Single submitter ⚠
- p.Ser150Gly Single submitter ⚠
- p.Ser258Leu Single submitter ⚠
- p.Ser281Asn Single submitter ⚠
- p.Ser85Arg Single submitter ⚠
- p.Ser8Ala Single submitter ⚠
- p.Ser97Asn Single submitter ⚠
- p.Thr100Ser Single submitter ⚠
- p.Thr114Ile Single submitter ⚠
- p.Thr128Ser Single submitter ⚠
- p.Thr161Lys Single submitter ⚠
- p.Thr163Asn Single submitter ⚠
- p.Thr184Ala Single submitter ⚠
- p.Thr184Ile Single submitter ⚠
- p.Thr37Met Single submitter ⚠
- p.Thr59Ile Single submitter ⚠
- p.Thr59Ser Single submitter ⚠
- p.Thr69Ala Single submitter ⚠
- p.Thr75Met Single submitter ⚠
- p.Thr83Ile Single submitter ⚠
- p.Thr84Ile Single submitter ⚠
- p.Thr84Ser Single submitter ⚠
- p.Trp255Cys Single submitter ⚠
- p.Tyr220Cys Single submitter ⚠
- p.Tyr237Asn Single submitter ⚠
- p.Tyr240Asp Single submitter ⚠
- p.Val121Ile Single submitter ⚠