CD69 — 16 ClinVar variants
All ClinVar germline CD69 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 12 flagged for review →
1 Benign · 3 Likely benign · 12 Uncertain significance
Full CD69 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 12
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 5
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 7
The independent predictors disagree with each other — read with care.
- CD69 p.Glu87Gly Uncertain significance Single submitter
- CD69 p.His151Tyr Uncertain significance Single submitter
- CD69 p.Ser13Phe Uncertain significance Single submitter
- CD69 p.Ser182Ile Uncertain significance Single submitter
- CD69 p.Ser86Phe Uncertain significance Single submitter
- CD69 p.Thr119Ile Uncertain significance Single submitter
- CD69 p.Val39Asp Uncertain significance Single submitter
All CD69 variants
Benign 1
- p.Lys177= Multiple submitters
Likely benign 3
- p.Arg32His Single submitter
- p.Ile53Val Single submitter
- p.Val143Ile Single submitter
Uncertain significance 12
- p.Asn22Lys Single submitter ⚠
- p.Asp171Asn Single submitter ⚠
- p.Cys96Arg Single submitter ⚠
- p.Glu87Gly Single submitter ⚠
- p.His151Tyr Single submitter ⚠
- p.Pro40Ser Single submitter ⚠
- p.Ser13Phe Single submitter ⚠
- p.Ser182Ile Single submitter ⚠
- p.Ser78Pro Single submitter ⚠
- p.Ser86Phe Single submitter ⚠
- p.Thr119Ile Single submitter ⚠
- p.Val39Asp Single submitter ⚠