CD7 — 52 ClinVar variants
All ClinVar germline CD7 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 44 flagged for review →
10 Likely benign · 42 Uncertain significance
Full CD7 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 44
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 16
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CD7 p.Ala145Thr Uncertain significance Single submitter
- CD7 p.Ala154Asp Uncertain significance Single submitter
- CD7 p.Ala15Val Uncertain significance Single submitter
- CD7 p.Ala217Thr Uncertain significance Single submitter
- CD7 p.Ala218Thr Uncertain significance Single submitter
- CD7 p.Arg229Ser Uncertain significance Single submitter
- CD7 p.Arg87His Uncertain significance Single submitter
- CD7 p.Asn237Ser Uncertain significance Single submitter
- CD7 p.Gln67Glu Uncertain significance Single submitter
- CD7 p.Gln94Arg Uncertain significance Single submitter
- CD7 p.Gly19Ser Uncertain significance Single submitter
- CD7 p.Gly19Val Uncertain significance Single submitter
- CD7 p.Gly53Asp Uncertain significance Single submitter
- CD7 p.Ile46Val Uncertain significance Single submitter
- CD7 p.Leu106Val Uncertain significance Single submitter
- CD7 p.Ser143Leu Uncertain significance Single submitter
Predictors split 28
The independent predictors disagree with each other — read with care.
- CD7 p.Ala154Thr Uncertain significance Single submitter
- CD7 p.Ala17Ser Uncertain significance Single submitter
- CD7 p.Ala184Val Uncertain significance Single submitter
- CD7 p.Arg212Gln Uncertain significance Single submitter
- CD7 p.Arg229Cys Uncertain significance Single submitter
- CD7 p.Arg83Trp Uncertain significance Single submitter
- CD7 p.Arg85Pro Uncertain significance Single submitter
- CD7 p.Asp81Glu Uncertain significance Single submitter
- CD7 p.Gln105His Uncertain significance Single submitter
- CD7 p.Gln165Glu Uncertain significance Single submitter
- CD7 p.Gly110Asp Uncertain significance Single submitter
- CD7 p.Gly124Ser Uncertain significance Single submitter
- CD7 p.Gly126Ser Uncertain significance Single submitter
- CD7 p.Gly193Ser Uncertain significance Single submitter
- CD7 p.Gly56Trp Uncertain significance Single submitter
- CD7 p.His140Tyr Uncertain significance Single submitter
- CD7 p.Leu12Pro Uncertain significance Single submitter
- CD7 p.Lys206Asn Uncertain significance Single submitter
- CD7 p.Pro155Leu Uncertain significance Single submitter
- CD7 p.Pro156Ala Uncertain significance Single submitter
- CD7 p.Pro173Leu Likely benign Single submitter
- CD7 p.Pro4Thr Uncertain significance Single submitter
- CD7 p.Pro5Leu Uncertain significance Single submitter
- CD7 p.Ser107Leu Uncertain significance Single submitter
- CD7 p.Ser159Phe Uncertain significance Single submitter
- CD7 p.Ser159Tyr Uncertain significance Single submitter
- CD7 p.Ser228Asn Uncertain significance Single submitter
- CD7 p.Val44Ile Likely benign Single submitter
All CD7 variants
Likely benign 10
- p.Ala181Val Single submitter
- p.Ala197Val Single submitter
- p.Arg103His Single submitter
- p.Asn215Ser Single submitter
- p.Gly75Arg Single submitter
- p.Leu106Pro Single submitter
- p.Pro173Leu Single submitter ⚠
- p.Pro39= Single submitter
- p.Pro4Ala Single submitter
- p.Val44Ile Single submitter ⚠
Uncertain significance 42
- p.Ala145Thr Single submitter ⚠
- p.Ala154Asp Single submitter ⚠
- p.Ala154Thr Single submitter ⚠
- p.Ala15Val Single submitter ⚠
- p.Ala17Ser Single submitter ⚠
- p.Ala184Val Single submitter ⚠
- p.Ala217Thr Single submitter ⚠
- p.Ala218Thr Single submitter ⚠
- p.Arg212Gln Single submitter ⚠
- p.Arg229Cys Single submitter ⚠
- p.Arg229Ser Single submitter ⚠
- p.Arg83Trp Single submitter ⚠
- p.Arg85Pro Single submitter ⚠
- p.Arg87His Single submitter ⚠
- p.Asn237Ser Single submitter ⚠
- p.Asp81Glu Single submitter ⚠
- p.Gln105His Single submitter ⚠
- p.Gln165Glu Single submitter ⚠
- p.Gln67Glu Single submitter ⚠
- p.Gln94Arg Single submitter ⚠
- p.Gly110Asp Single submitter ⚠
- p.Gly124Ser Single submitter ⚠
- p.Gly126Ser Single submitter ⚠
- p.Gly193Ser Single submitter ⚠
- p.Gly19Ser Single submitter ⚠
- p.Gly19Val Single submitter ⚠
- p.Gly53Asp Single submitter ⚠
- p.Gly56Trp Single submitter ⚠
- p.His140Tyr Single submitter ⚠
- p.Ile46Val Single submitter ⚠
- p.Leu106Val Single submitter ⚠
- p.Leu12Pro Single submitter ⚠
- p.Lys206Asn Single submitter ⚠
- p.Pro155Leu Single submitter ⚠
- p.Pro156Ala Single submitter ⚠
- p.Pro4Thr Single submitter ⚠
- p.Pro5Leu Single submitter ⚠
- p.Ser107Leu Single submitter ⚠
- p.Ser143Leu Single submitter ⚠
- p.Ser159Phe Single submitter ⚠
- p.Ser159Tyr Single submitter ⚠
- p.Ser228Asn Single submitter ⚠