CD79A — 177 ClinVar variants
All ClinVar germline CD79A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 73 flagged for review →
5 Pathogenic · 2 Likely pathogenic · 5 Conflicting · 7 Benign · 84 Likely benign · 74 Uncertain significance
Full CD79A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 73
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors agree, ClinVar conflicts 2
ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.
-
CD79A p.Ala10Thr
Conflicting
Single submitter
agammaglobulinemia 3, autosomal recessive
-
CD79A p.Arg68His
Conflicting
Single submitter
agammaglobulinemia 3, autosomal recessive
Predictors lean, ClinVar uncertain 42
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
-
CD79A p.Arg124Cys
Uncertain significance
Multiple submitters
agammaglobulinemia 3, autosomal recessive
-
CD79A p.Arg124His
Uncertain significance
Multiple submitters
agammaglobulinemia 3, autosomal recessive
-
CD79A p.Asn60Ser
Uncertain significance
Multiple submitters
agammaglobulinemia 3, autosomal recessive
-
CD79A p.Asn63Ser
Uncertain significance
Multiple submitters
agammaglobulinemia 3, autosomal recessive
-
CD79A p.Gly179Arg
Uncertain significance
Multiple submitters
agammaglobulinemia 3, autosomal recessive
-
CD79A p.Ile151Thr
Uncertain significance
Multiple submitters
agammaglobulinemia 3, autosomal recessive
-
CD79A p.Ser215Gly
Uncertain significance
Multiple submitters
agammaglobulinemia 3, autosomal recessive
-
CD79A p.Ser45Thr
Uncertain significance
Multiple submitters
agammaglobulinemia 3, autosomal recessive
-
CD79A p.Val105Met
Uncertain significance
Multiple submitters
agammaglobulinemia 3, autosomal recessive
-
CD79A p.Val125Met
Uncertain significance
Multiple submitters
agammaglobulinemia 3, autosomal recessive
-
CD79A p.Ala156Thr
Uncertain significance
Single submitter
agammaglobulinemia 3, autosomal recessive
-
CD79A p.Ala156Val
Uncertain significance
Single submitter
agammaglobulinemia 3, autosomal recessive
-
CD79A p.Ala62Thr
Uncertain significance
Single submitter
agammaglobulinemia 3, autosomal recessive
-
CD79A p.Arg143Gln
Uncertain significance
Single submitter
agammaglobulinemia 3, autosomal recessive
-
CD79A p.Arg166Ser
Uncertain significance
Single submitter
agammaglobulinemia 3, autosomal recessive
-
CD79A p.Arg168Gly
Uncertain significance
Single submitter
agammaglobulinemia 3, autosomal recessive
-
CD79A p.Asn217Ile
Uncertain significance
Single submitter
agammaglobulinemia 3, autosomal recessive
-
CD79A p.Asn61Ile
Uncertain significance
Single submitter
agammaglobulinemia 3, autosomal recessive
-
CD79A p.Asn88Ser
Uncertain significance
Single submitter
agammaglobulinemia 3, autosomal recessive
- CD79A p.Asp86Ala Uncertain significance Single submitter
-
CD79A p.Asp86Glu
Uncertain significance
Single submitter
agammaglobulinemia 3, autosomal recessive
-
CD79A p.Glu113Gly
Uncertain significance
Single submitter
agammaglobulinemia 3, autosomal recessive
-
CD79A p.Glu148Lys
Uncertain significance
Single submitter
agammaglobulinemia 3, autosomal recessive
-
CD79A p.Glu172Lys
Uncertain significance
Single submitter
agammaglobulinemia 3, autosomal recessive
-
CD79A p.Glu85Lys
Uncertain significance
Single submitter
agammaglobulinemia 3, autosomal recessive
-
CD79A p.Gly120Ser
Uncertain significance
Single submitter
agammaglobulinemia 3, autosomal recessive
-
CD79A p.Gly139Asp
Uncertain significance
Single submitter
agammaglobulinemia 3, autosomal recessive
-
CD79A p.Gly175Arg
Uncertain significance
Single submitter
agammaglobulinemia 3, autosomal recessive
- CD79A p.Gly214Ala Uncertain significance Single submitter
-
CD79A p.Gly27Val
Uncertain significance
Single submitter
agammaglobulinemia 3, autosomal recessive
-
CD79A p.Gly3Ala
Uncertain significance
Single submitter
agammaglobulinemia 3, autosomal recessive
- CD79A p.Lys173Gln Uncertain significance Single submitter
-
CD79A p.Met43Lys
Uncertain significance
Single submitter
agammaglobulinemia 3, autosomal recessive
- CD79A p.Pro5Ser Uncertain significance Single submitter
-
CD79A p.Pro87Ser
Uncertain significance
Single submitter
agammaglobulinemia 3, autosomal recessive
-
CD79A p.Ser22Thr
Uncertain significance
Single submitter
agammaglobulinemia 3, autosomal recessive
-
CD79A p.Thr75Lys
Uncertain significance
Single submitter
agammaglobulinemia 3, autosomal recessive
-
CD79A p.Tyr104His
Uncertain significance
Single submitter
agammaglobulinemia 3, autosomal recessive
-
CD79A p.Val125Gly
Uncertain significance
Single submitter
agammaglobulinemia 3, autosomal recessive
- CD79A p.Val157Ala Uncertain significance Single submitter
-
CD79A p.Val157Met
Uncertain significance
Single submitter
agammaglobulinemia 3, autosomal recessive
-
CD79A p.Val64Ile
Uncertain significance
Single submitter
agammaglobulinemia 3, autosomal recessive
Predictors split 29
The independent predictors disagree with each other — read with care.
-
CD79A p.Arg204Gln
Uncertain significance
Multiple submitters
agammaglobulinemia 3, autosomal recessive
-
CD79A p.Ile218Lys
Uncertain significance
Multiple submitters
agammaglobulinemia 3, autosomal recessive
-
CD79A p.Pro132Leu
Uncertain significance
Multiple submitters
agammaglobulinemia 3, autosomal recessive
-
CD79A p.Thr140Ile
Uncertain significance
Multiple submitters
agammaglobulinemia 3, autosomal recessive
-
CD79A p.Thr75Met
Uncertain significance
Multiple submitters
agammaglobulinemia 3, autosomal recessive
-
CD79A p.Thr90Met
Uncertain significance
Multiple submitters
agammaglobulinemia 3, autosomal recessive
-
CD79A p.Arg107Gln
Uncertain significance
Single submitter
agammaglobulinemia 3, autosomal recessive
-
CD79A p.Arg126His
Uncertain significance
Single submitter
agammaglobulinemia 3, autosomal recessive
-
CD79A p.Arg168Gln
Uncertain significance
Single submitter
agammaglobulinemia 3, autosomal recessive
-
CD79A p.Arg204Gly
Uncertain significance
Single submitter
agammaglobulinemia 3, autosomal recessive
-
CD79A p.Arg68Cys
Uncertain significance
Single submitter
agammaglobulinemia 3, autosomal recessive
-
CD79A p.Asn112Ser
Uncertain significance
Single submitter
agammaglobulinemia 3, autosomal recessive
-
CD79A p.Asn192Lys
Uncertain significance
Single submitter
agammaglobulinemia 3, autosomal recessive
-
CD79A p.Asn63Ile
Uncertain significance
Single submitter
agammaglobulinemia 3, autosomal recessive
-
CD79A p.Asp195Asn
Uncertain significance
Single submitter
agammaglobulinemia 3, autosomal recessive
- CD79A p.Gly205Ser Uncertain significance Single submitter
-
CD79A p.Ile103Met
Conflicting
Single submitter
agammaglobulinemia 3, autosomal recessive
-
CD79A p.Leu46Pro
Uncertain significance
Single submitter
agammaglobulinemia 3, autosomal recessive
-
CD79A p.Leu81Ser
Uncertain significance
Single submitter
agammaglobulinemia 3, autosomal recessive
-
CD79A p.Met198Thr
Uncertain significance
Single submitter
agammaglobulinemia 3, autosomal recessive
-
CD79A p.Phe165Leu
Uncertain significance
Single submitter
agammaglobulinemia 3, autosomal recessive
-
CD79A p.Pro132Thr
Uncertain significance
Single submitter
agammaglobulinemia 3, autosomal recessive
-
CD79A p.Pro226Gln
Uncertain significance
Single submitter
agammaglobulinemia 3, autosomal recessive
-
CD79A p.Pro226Leu
Uncertain significance
Single submitter
agammaglobulinemia 3, autosomal recessive
- CD79A p.Pro28Arg Uncertain significance Single submitter
-
CD79A p.Pro55Leu
Conflicting
Single submitter
agammaglobulinemia 3, autosomal recessive
-
CD79A p.Ser114Leu
Uncertain significance
Single submitter
agammaglobulinemia 3, autosomal recessive
-
CD79A p.Thr140Asn
Conflicting
Single submitter
agammaglobulinemia 3, autosomal recessive
-
CD79A p.Val108Gly
Pathogenic
Single submitter
Inherited Immunodeficiency Diseases
All CD79A variants
Pathogenic 5
- p.Ala23fs Single submitter agammaglobulinemia 3, autosomal recessive
- p.Cys155Ter Single submitter agammaglobulinemia 3, autosomal recessive
- p.Trp66Ter Single submitter agammaglobulinemia 3, autosomal recessive
- p.Val108Gly Single submitter Inherited Immunodeficiency Diseases ⚠
- c.380-2A>G No assertion criteria agammaglobulinemia 3, autosomal recessive
Likely pathogenic 2
- c.379+1G>A Single submitter agammaglobulinemia 3, autosomal recessive
- c.499-1G>A Single submitter agammaglobulinemia 3, autosomal recessive
Conflicting classifications of pathogenicity 5
- p.Ala10Thr Single submitter agammaglobulinemia 3, autosomal recessive ⚠
- p.Arg68His Single submitter agammaglobulinemia 3, autosomal recessive ⚠
- p.Ile103Met Single submitter agammaglobulinemia 3, autosomal recessive ⚠
- p.Pro55Leu Single submitter agammaglobulinemia 3, autosomal recessive ⚠
- p.Thr140Asn Single submitter agammaglobulinemia 3, autosomal recessive ⚠
Benign 7
- c.379+23dup Single submitter agammaglobulinemia 3, autosomal recessive
- c.498+195G>T Single submitter
- c.499-10A>C Single submitter agammaglobulinemia 3, autosomal recessive
- c.499-14A>C Single submitter agammaglobulinemia 3, autosomal recessive
- c.499-212_499-210dup Single submitter
- c.499-218GGAA[14] Single submitter
- c.80-303G>A Single submitter
Likely benign 84
- c.498+12C>T Multiple submitters agammaglobulinemia 3, autosomal recessive
- p.Arg124= Multiple submitters agammaglobulinemia 3, autosomal recessive
- p.Asn61= Multiple submitters agammaglobulinemia 3, autosomal recessive
- p.Asp194= Multiple submitters agammaglobulinemia 3, autosomal recessive
- p.Thr90= Multiple submitters agammaglobulinemia 3, autosomal recessive
- p.Tyr104= Multiple submitters agammaglobulinemia 3, autosomal recessive
- c.379+19G>T Single submitter agammaglobulinemia 3, autosomal recessive
- c.380-13T>C Single submitter agammaglobulinemia 3, autosomal recessive
- c.380-14C>A Single submitter agammaglobulinemia 3, autosomal recessive
- c.380-7C>T Single submitter agammaglobulinemia 3, autosomal recessive
- c.380-8C>T Single submitter agammaglobulinemia 3, autosomal recessive
- c.498+10C>A Single submitter agammaglobulinemia 3, autosomal recessive
- c.498+13G>A Single submitter agammaglobulinemia 3, autosomal recessive
- c.498+7C>T Single submitter agammaglobulinemia 3, autosomal recessive
- c.498+8C>T Single submitter agammaglobulinemia 3, autosomal recessive
- c.499-11C>T Single submitter agammaglobulinemia 3, autosomal recessive
- c.499-15C>T Single submitter agammaglobulinemia 3, autosomal recessive
- c.499-17C>T Single submitter agammaglobulinemia 3, autosomal recessive
- c.499-18C>A Single submitter agammaglobulinemia 3, autosomal recessive
- c.499-18C>T Single submitter agammaglobulinemia 3, autosomal recessive
- c.499-8C>T Single submitter agammaglobulinemia 3, autosomal recessive
- c.567+12G>A Single submitter agammaglobulinemia 3, autosomal recessive
- c.567+15G>C Single submitter agammaglobulinemia 3, autosomal recessive
- c.567+19T>G Single submitter agammaglobulinemia 3, autosomal recessive
- c.567+20_567+21delinsAT Single submitter agammaglobulinemia 3, autosomal recessive
- c.568-16C>T Single submitter agammaglobulinemia 3, autosomal recessive
- c.568-6T>C Single submitter agammaglobulinemia 3, autosomal recessive
- c.568-9C>G Single submitter agammaglobulinemia 3, autosomal recessive
- c.79+12A>G Single submitter agammaglobulinemia 3, autosomal recessive
- c.79+14G>A Single submitter agammaglobulinemia 3, autosomal recessive
- c.79+15G>A Single submitter agammaglobulinemia 3, autosomal recessive
- c.79+8G>A Single submitter agammaglobulinemia 3, autosomal recessive
- c.80-12G>A Single submitter agammaglobulinemia 3, autosomal recessive
- c.80-13T>G Single submitter agammaglobulinemia 3, autosomal recessive
- c.80-8C>G Single submitter agammaglobulinemia 3, autosomal recessive
- p.Ala10= Single submitter agammaglobulinemia 3, autosomal recessive
- p.Ala178= Single submitter agammaglobulinemia 3, autosomal recessive
- p.Ala40= Single submitter agammaglobulinemia 3, autosomal recessive
- p.Ala50= Single submitter agammaglobulinemia 3, autosomal recessive
- p.Arg143= Single submitter agammaglobulinemia 3, autosomal recessive
- p.Arg68= Single submitter agammaglobulinemia 3, autosomal recessive
- p.Asn112= Single submitter agammaglobulinemia 3, autosomal recessive
- p.Asn171= Single submitter agammaglobulinemia 3, autosomal recessive
- p.Asn63= Single submitter agammaglobulinemia 3, autosomal recessive
- p.Asp184= Single submitter agammaglobulinemia 3, autosomal recessive
- p.Asp49= Single submitter agammaglobulinemia 3, autosomal recessive
- p.Cys119= Single submitter agammaglobulinemia 3, autosomal recessive
- p.Cys155= Single submitter agammaglobulinemia 3, autosomal recessive
- p.Gln109= Single submitter agammaglobulinemia 3, autosomal recessive
- p.Gln53= Single submitter agammaglobulinemia 3, autosomal recessive
- p.Gly101Arg Single submitter agammaglobulinemia 3, autosomal recessive
- p.Gly175= Single submitter agammaglobulinemia 3, autosomal recessive
- p.Gly208= Single submitter agammaglobulinemia 3, autosomal recessive
- p.Gly27= Single submitter
- p.Gly29= Single submitter
- p.Gly4= Single submitter agammaglobulinemia 3, autosomal recessive
- p.His36= Single submitter agammaglobulinemia 3, autosomal recessive
- p.Ile103= Single submitter agammaglobulinemia 3, autosomal recessive
- p.Ile151= Single submitter agammaglobulinemia 3, autosomal recessive
- p.Leu134= Single submitter agammaglobulinemia 3, autosomal recessive
- p.Leu153= Single submitter
- p.Leu163= Single submitter agammaglobulinemia 3, autosomal recessive
- p.Leu164= Single submitter agammaglobulinemia 3, autosomal recessive
- p.Leu17= Single submitter agammaglobulinemia 3, autosomal recessive
- p.Leu174= Single submitter agammaglobulinemia 3, autosomal recessive
- p.Leu18= Single submitter agammaglobulinemia 3, autosomal recessive
- p.Leu187= Single submitter agammaglobulinemia 3, autosomal recessive
- p.Leu20= Single submitter agammaglobulinemia 3, autosomal recessive
- p.Leu21= Single submitter agammaglobulinemia 3, autosomal recessive
- p.Leu70= Single submitter agammaglobulinemia 3, autosomal recessive
- p.Leu8= Single submitter agammaglobulinemia 3, autosomal recessive
- p.Lys173= Single submitter agammaglobulinemia 3, autosomal recessive
- p.Met43Thr Single submitter
- p.Pro128= Single submitter agammaglobulinemia 3, autosomal recessive
- p.Pro129= Single submitter agammaglobulinemia 3, autosomal recessive
- p.Pro226= Single submitter agammaglobulinemia 3, autosomal recessive
- p.Pro55= Single submitter agammaglobulinemia 3, autosomal recessive
- p.Pro83= Single submitter agammaglobulinemia 3, autosomal recessive
- p.Thr140= Single submitter agammaglobulinemia 3, autosomal recessive
- p.Thr161= Single submitter agammaglobulinemia 3, autosomal recessive
- p.Thr75= Single submitter agammaglobulinemia 3, autosomal recessive
- p.Val125= Single submitter agammaglobulinemia 3, autosomal recessive
- p.Val7= Single submitter agammaglobulinemia 3, autosomal recessive
- c.*4C>T No assertion criteria CD79A-related disorder
Uncertain significance 74
- p.Arg124Cys Multiple submitters agammaglobulinemia 3, autosomal recessive ⚠
- p.Arg124His Multiple submitters agammaglobulinemia 3, autosomal recessive ⚠
- p.Arg204Gln Multiple submitters agammaglobulinemia 3, autosomal recessive ⚠
- p.Asn60Ser Multiple submitters agammaglobulinemia 3, autosomal recessive ⚠
- p.Asn63Ser Multiple submitters agammaglobulinemia 3, autosomal recessive ⚠
- p.Gly179Arg Multiple submitters agammaglobulinemia 3, autosomal recessive ⚠
- p.Ile151Thr Multiple submitters agammaglobulinemia 3, autosomal recessive ⚠
- p.Ile218Lys Multiple submitters agammaglobulinemia 3, autosomal recessive ⚠
- p.Pro132Leu Multiple submitters agammaglobulinemia 3, autosomal recessive ⚠
- p.Ser215Gly Multiple submitters agammaglobulinemia 3, autosomal recessive ⚠
- p.Ser45Thr Multiple submitters agammaglobulinemia 3, autosomal recessive ⚠
- p.Thr140Ile Multiple submitters agammaglobulinemia 3, autosomal recessive ⚠
- p.Thr75Met Multiple submitters agammaglobulinemia 3, autosomal recessive ⚠
- p.Thr90Met Multiple submitters agammaglobulinemia 3, autosomal recessive ⚠
- p.Val105Met Multiple submitters agammaglobulinemia 3, autosomal recessive ⚠
- p.Val125Met Multiple submitters agammaglobulinemia 3, autosomal recessive ⚠
- c.379+3G>A Single submitter agammaglobulinemia 3, autosomal recessive
- c.498+6C>A Single submitter agammaglobulinemia 3, autosomal recessive
- c.79+6T>C Single submitter agammaglobulinemia 3, autosomal recessive
- c.80-3C>T Single submitter agammaglobulinemia 3, autosomal recessive
- p.Ala156Leu Single submitter agammaglobulinemia 3, autosomal recessive
- p.Ala156Thr Single submitter agammaglobulinemia 3, autosomal recessive ⚠
- p.Ala156Val Single submitter agammaglobulinemia 3, autosomal recessive ⚠
- p.Ala62Thr Single submitter agammaglobulinemia 3, autosomal recessive ⚠
- p.Arg107Gln Single submitter agammaglobulinemia 3, autosomal recessive ⚠
- p.Arg126His Single submitter agammaglobulinemia 3, autosomal recessive ⚠
- p.Arg143Gln Single submitter agammaglobulinemia 3, autosomal recessive ⚠
- p.Arg166Ser Single submitter agammaglobulinemia 3, autosomal recessive ⚠
- p.Arg168Gln Single submitter agammaglobulinemia 3, autosomal recessive ⚠
- p.Arg168Gly Single submitter agammaglobulinemia 3, autosomal recessive ⚠
- p.Arg204Gly Single submitter agammaglobulinemia 3, autosomal recessive ⚠
- p.Arg68Cys Single submitter agammaglobulinemia 3, autosomal recessive ⚠
- p.Asn112Ser Single submitter agammaglobulinemia 3, autosomal recessive ⚠
- p.Asn192Lys Single submitter agammaglobulinemia 3, autosomal recessive ⚠
- p.Asn217Ile Single submitter agammaglobulinemia 3, autosomal recessive ⚠
- p.Asn61Ile Single submitter agammaglobulinemia 3, autosomal recessive ⚠
- p.Asn63Ile Single submitter agammaglobulinemia 3, autosomal recessive ⚠
- p.Asn88Ser Single submitter agammaglobulinemia 3, autosomal recessive ⚠
- p.Asp195Asn Single submitter agammaglobulinemia 3, autosomal recessive ⚠
- p.Asp86Ala Single submitter ⚠
- p.Asp86Glu Single submitter agammaglobulinemia 3, autosomal recessive ⚠
- p.Cys155Leu Single submitter agammaglobulinemia 3, autosomal recessive
- p.Gln222Ter Single submitter agammaglobulinemia 3, autosomal recessive
- p.Glu113Gly Single submitter agammaglobulinemia 3, autosomal recessive ⚠
- p.Glu148Lys Single submitter agammaglobulinemia 3, autosomal recessive ⚠
- p.Glu172Lys Single submitter agammaglobulinemia 3, autosomal recessive ⚠
- p.Glu85Lys Single submitter agammaglobulinemia 3, autosomal recessive ⚠
- p.Gly120Ser Single submitter agammaglobulinemia 3, autosomal recessive ⚠
- p.Gly139Asp Single submitter agammaglobulinemia 3, autosomal recessive ⚠
- p.Gly175Arg Single submitter agammaglobulinemia 3, autosomal recessive ⚠
- p.Gly205Ser Single submitter ⚠
- p.Gly214Ala Single submitter ⚠
- p.Gly27Val Single submitter agammaglobulinemia 3, autosomal recessive ⚠
- p.Gly3Ala Single submitter agammaglobulinemia 3, autosomal recessive ⚠
- p.Leu46Pro Single submitter agammaglobulinemia 3, autosomal recessive ⚠
- p.Leu81Ser Single submitter agammaglobulinemia 3, autosomal recessive ⚠
- p.Lys173Gln Single submitter ⚠
- p.Met198Thr Single submitter agammaglobulinemia 3, autosomal recessive ⚠
- p.Met43Lys Single submitter agammaglobulinemia 3, autosomal recessive ⚠
- p.Phe165Leu Single submitter agammaglobulinemia 3, autosomal recessive ⚠
- p.Pro132Thr Single submitter agammaglobulinemia 3, autosomal recessive ⚠
- p.Pro226Gln Single submitter agammaglobulinemia 3, autosomal recessive ⚠
- p.Pro226Leu Single submitter agammaglobulinemia 3, autosomal recessive ⚠
- p.Pro28Arg Single submitter ⚠
- p.Pro5Ser Single submitter ⚠
- p.Pro87Ser Single submitter agammaglobulinemia 3, autosomal recessive ⚠
- p.Ser114Leu Single submitter agammaglobulinemia 3, autosomal recessive ⚠
- p.Ser22Thr Single submitter agammaglobulinemia 3, autosomal recessive ⚠
- p.Thr75Lys Single submitter agammaglobulinemia 3, autosomal recessive ⚠
- p.Tyr104His Single submitter agammaglobulinemia 3, autosomal recessive ⚠
- p.Val125Gly Single submitter agammaglobulinemia 3, autosomal recessive ⚠
- p.Val157Ala Single submitter ⚠
- p.Val157Met Single submitter agammaglobulinemia 3, autosomal recessive ⚠
- p.Val64Ile Single submitter agammaglobulinemia 3, autosomal recessive ⚠