CD79B — 176 ClinVar variants
All ClinVar germline CD79B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 57 flagged for review →
2 Pathogenic · 1 Likely pathogenic · 3 Conflicting · 12 Benign · 1 Benign/Likely benign · 96 Likely benign · 61 Uncertain significance
Full CD79B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 57
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors agree, ClinVar conflicts 2
ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.
-
CD79B p.Glu84Lys
Conflicting
Single submitter
agammaglobulinemia 6, autosomal recessive
-
CD79B p.Ser130Leu
Conflicting
Single submitter
agammaglobulinemia 6, autosomal recessive
Predictors lean, ClinVar uncertain 35
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
-
CD79B p.Ala5Val
Uncertain significance
Multiple submitters
agammaglobulinemia 6, autosomal recessive
-
CD79B p.Arg36Trp
Uncertain significance
Multiple submitters
agammaglobulinemia 6, autosomal recessive
-
CD79B p.Ala16Val
Uncertain significance
Single submitter
agammaglobulinemia 6, autosomal recessive
-
CD79B p.Ala188Pro
Uncertain significance
Single submitter
agammaglobulinemia 6, autosomal recessive
-
CD79B p.Ala42Thr
Uncertain significance
Single submitter
agammaglobulinemia 6, autosomal recessive
-
CD79B p.Ala70Thr
Uncertain significance
Single submitter
agammaglobulinemia 6, autosomal recessive
-
CD79B p.Arg141Gln
Uncertain significance
Single submitter
agammaglobulinemia 6, autosomal recessive
-
CD79B p.Arg214Gln
Uncertain significance
Single submitter
agammaglobulinemia 6, autosomal recessive
- CD79B p.Arg34Gln Uncertain significance Single submitter
- CD79B p.Arg34Pro Uncertain significance Single submitter
-
CD79B p.Arg51His
Uncertain significance
Single submitter
agammaglobulinemia 6, autosomal recessive
- CD79B p.Asn37His Uncertain significance Single submitter
-
CD79B p.Asn73Thr
Uncertain significance
Single submitter
agammaglobulinemia 6, autosomal recessive
-
CD79B p.Asp184Glu
Uncertain significance
Single submitter
agammaglobulinemia 6, autosomal recessive
-
CD79B p.Gln100Arg
Uncertain significance
Single submitter
agammaglobulinemia 6, autosomal recessive
-
CD79B p.Gln110Arg
Uncertain significance
Single submitter
agammaglobulinemia 6, autosomal recessive
- CD79B p.Gln203Lys Uncertain significance Single submitter
-
CD79B p.Glu102Lys
Uncertain significance
Single submitter
agammaglobulinemia 6, autosomal recessive
-
CD79B p.Glu191Gln
Uncertain significance
Single submitter
agammaglobulinemia 6, autosomal recessive
-
CD79B p.Glu32Gln
Uncertain significance
Single submitter
agammaglobulinemia 6, autosomal recessive
- CD79B p.Glu98Lys Uncertain significance Single submitter
-
CD79B p.Gly227Ser
Uncertain significance
Single submitter
agammaglobulinemia 6, autosomal recessive
- CD79B p.Ile162Val Uncertain significance Single submitter
-
CD79B p.Lys183Glu
Uncertain significance
Single submitter
agammaglobulinemia 6, autosomal recessive
-
CD79B p.Met82Arg
Uncertain significance
Single submitter
agammaglobulinemia 6, autosomal recessive
- CD79B p.Met82Val Uncertain significance Single submitter
-
CD79B p.Met96Val
Uncertain significance
Single submitter
agammaglobulinemia 6, autosomal recessive
-
CD79B p.Phe114Cys
Uncertain significance
Single submitter
agammaglobulinemia 6, autosomal recessive
-
CD79B p.Phe121Cys
Uncertain significance
Single submitter
agammaglobulinemia 6, autosomal recessive
- CD79B p.Pro38Ser Uncertain significance Single submitter
-
CD79B p.Ser186Asn
Uncertain significance
Single submitter
agammaglobulinemia 6, autosomal recessive
-
CD79B p.Ser44Leu
Uncertain significance
Single submitter
agammaglobulinemia 6, autosomal recessive
- CD79B p.Thr106Ile Uncertain significance Single submitter
-
CD79B p.Thr156Met
Uncertain significance
Single submitter
agammaglobulinemia 6, autosomal recessive
-
CD79B p.Val222Ile
Uncertain significance
Single submitter
agammaglobulinemia 6, autosomal recessive
Predictors split 20
The independent predictors disagree with each other — read with care.
-
CD79B p.Gly216Arg
Uncertain significance
Multiple submitters
agammaglobulinemia 6, autosomal recessive
-
CD79B p.Leu91Pro
Uncertain significance
Multiple submitters
agammaglobulinemia 6, autosomal recessive
-
CD79B p.Val175Met
Uncertain significance
Multiple submitters
CD79B-related disorder
-
CD79B p.Ala54Thr
Uncertain significance
Single submitter
agammaglobulinemia 6, autosomal recessive
-
CD79B p.Arg57Pro
Uncertain significance
Single submitter
agammaglobulinemia 6, autosomal recessive
-
CD79B p.Asn127Asp
Uncertain significance
Single submitter
agammaglobulinemia 6, autosomal recessive
-
CD79B p.Asn73Asp
Uncertain significance
Single submitter
agammaglobulinemia 6, autosomal recessive
- CD79B p.Glu197Gln Uncertain significance Single submitter
- CD79B p.Gly72Ser Likely benign Single submitter
-
CD79B p.Leu181Gln
Uncertain significance
Single submitter
agammaglobulinemia 6, autosomal recessive
-
CD79B p.Met143Ile
Uncertain significance
Single submitter
agammaglobulinemia 6, autosomal recessive
-
CD79B p.Pro86Thr
Uncertain significance
Single submitter
agammaglobulinemia 6, autosomal recessive
-
CD79B p.Ser31Trp
Uncertain significance
Single submitter
agammaglobulinemia 6, autosomal recessive
-
CD79B p.Ser69Gly
Uncertain significance
Single submitter
agammaglobulinemia 6, autosomal recessive
-
CD79B p.Thr108Ile
Uncertain significance
Single submitter
agammaglobulinemia 6, autosomal recessive
-
CD79B p.Thr166Met
Uncertain significance
Single submitter
agammaglobulinemia 6, autosomal recessive
-
CD79B p.Thr195Ser
Uncertain significance
Single submitter
agammaglobulinemia 6, autosomal recessive
-
CD79B p.Thr212Met
Uncertain significance
Single submitter
agammaglobulinemia 6, autosomal recessive
- CD79B p.Val222Leu Uncertain significance Single submitter
-
CD79B p.Gly137Ser
Pathogenic
No assertion criteria
agammaglobulinemia 6, autosomal recessive
All CD79B variants
Pathogenic 2
- p.Gln80Ter No assertion criteria agammaglobulinemia 6, autosomal recessive
- p.Gly137Ser No assertion criteria agammaglobulinemia 6, autosomal recessive ⚠
Likely pathogenic 1
- p.Tyr196His No assertion criteria diffuse large B-cell lymphoma
Conflicting classifications of pathogenicity 3
- p.Glu84Lys Single submitter agammaglobulinemia 6, autosomal recessive ⚠
- p.Ser130Leu Single submitter agammaglobulinemia 6, autosomal recessive ⚠
- p.Thr138= Single submitter agammaglobulinemia 6, autosomal recessive
Benign 12
- c.118+258G>A Multiple submitters
- c.*153C>G Multiple submitters
- c.*154C>T Multiple submitters
- c.*89T>C Multiple submitters
- p.Cys122= Multiple submitters agammaglobulinemia 6, autosomal recessive
- p.Leu104= Multiple submitters agammaglobulinemia 6, autosomal recessive
- c.549+11del Single submitter agammaglobulinemia 6, autosomal recessive
- c.549+133A>G Single submitter
- c.550-17T>C Single submitter agammaglobulinemia 6, autosomal recessive
- c.550-8G>A Single submitter agammaglobulinemia 6, autosomal recessive
- c.67+17G>C Single submitter agammaglobulinemia 6, autosomal recessive
- c.68-220A>C Single submitter
Benign/Likely benign 1
- c.118+12C>T Multiple submitters agammaglobulinemia 6, autosomal recessive
Likely benign 96
- c.67+10C>A Multiple submitters agammaglobulinemia 6, autosomal recessive
- c.68-5A>G Multiple submitters agammaglobulinemia 6, autosomal recessive
- p.Arg34= Multiple submitters agammaglobulinemia 6, autosomal recessive
- c.118+13G>A Single submitter agammaglobulinemia 6, autosomal recessive
- c.118+15C>T Single submitter agammaglobulinemia 6, autosomal recessive
- c.118+19C>T Single submitter agammaglobulinemia 6, autosomal recessive
- c.430+10A>C Single submitter agammaglobulinemia 6, autosomal recessive
- c.430+12del Single submitter agammaglobulinemia 6, autosomal recessive
- c.430+8C>A Single submitter agammaglobulinemia 6, autosomal recessive
- c.431-12_431-11del Single submitter agammaglobulinemia 6, autosomal recessive
- c.431-13C>T Single submitter agammaglobulinemia 6, autosomal recessive
- c.431-15C>A Single submitter agammaglobulinemia 6, autosomal recessive
- c.431-15C>T Single submitter agammaglobulinemia 6, autosomal recessive
- c.431-18C>G Single submitter agammaglobulinemia 6, autosomal recessive
- c.431-18C>T Single submitter agammaglobulinemia 6, autosomal recessive
- c.431-19C>T Single submitter agammaglobulinemia 6, autosomal recessive
- c.431-20C>A Single submitter agammaglobulinemia 6, autosomal recessive
- c.431-20C>T Single submitter agammaglobulinemia 6, autosomal recessive
- c.431-3C>T Single submitter agammaglobulinemia 6, autosomal recessive
- c.431-4G>A Single submitter agammaglobulinemia 6, autosomal recessive
- c.431-5C>T Single submitter agammaglobulinemia 6, autosomal recessive
- c.431-8C>G Single submitter agammaglobulinemia 6, autosomal recessive
- c.549+11G>A Single submitter agammaglobulinemia 6, autosomal recessive
- c.549+11G>T Single submitter agammaglobulinemia 6, autosomal recessive
- c.549+13C>T Single submitter agammaglobulinemia 6, autosomal recessive
- c.549+14G>A Single submitter agammaglobulinemia 6, autosomal recessive
- c.549+16G>A Single submitter agammaglobulinemia 6, autosomal recessive
- c.549+17G>T Single submitter agammaglobulinemia 6, autosomal recessive
- c.549+7A>G Single submitter agammaglobulinemia 6, autosomal recessive
- c.549+9G>A Single submitter agammaglobulinemia 6, autosomal recessive
- c.549+9G>C Single submitter agammaglobulinemia 6, autosomal recessive
- c.550-15C>A Single submitter agammaglobulinemia 6, autosomal recessive
- c.550-19C>A Single submitter agammaglobulinemia 6, autosomal recessive
- c.550-6C>T Single submitter agammaglobulinemia 6, autosomal recessive
- c.550-9C>T Single submitter agammaglobulinemia 6, autosomal recessive
- c.591+13G>A Single submitter agammaglobulinemia 6, autosomal recessive
- c.591+16G>A Single submitter agammaglobulinemia 6, autosomal recessive
- c.592-6C>G Single submitter agammaglobulinemia 6, autosomal recessive
- c.67+14G>A Single submitter agammaglobulinemia 6, autosomal recessive
- c.67+16C>T Single submitter agammaglobulinemia 6, autosomal recessive
- c.67+18A>G Single submitter agammaglobulinemia 6, autosomal recessive
- c.67+9C>A Single submitter agammaglobulinemia 6, autosomal recessive
- c.67+9C>T Single submitter agammaglobulinemia 6, autosomal recessive
- c.68-10C>A Single submitter agammaglobulinemia 6, autosomal recessive
- c.68-7C>T Single submitter agammaglobulinemia 6, autosomal recessive
- p.Ala16= Single submitter agammaglobulinemia 6, autosomal recessive
- p.Ala5= Single submitter agammaglobulinemia 6, autosomal recessive
- p.Ala54= Single submitter agammaglobulinemia 6, autosomal recessive
- p.Arg154= Single submitter agammaglobulinemia 6, autosomal recessive
- p.Arg30= Single submitter
- p.Arg55= Single submitter agammaglobulinemia 6, autosomal recessive
- p.Asn101= Single submitter agammaglobulinemia 6, autosomal recessive
- p.Asn117= Single submitter agammaglobulinemia 6, autosomal recessive
- p.Asn127= Single submitter agammaglobulinemia 6, autosomal recessive
- p.Asn85= Single submitter agammaglobulinemia 6, autosomal recessive
- p.Cys136= Single submitter agammaglobulinemia 6, autosomal recessive
- p.Gln124= Single submitter agammaglobulinemia 6, autosomal recessive
- p.Gln48= Single submitter agammaglobulinemia 6, autosomal recessive
- p.Gln87= Single submitter agammaglobulinemia 6, autosomal recessive
- p.Glu224= Single submitter agammaglobulinemia 6, autosomal recessive
- p.Glu229= Single submitter agammaglobulinemia 6, autosomal recessive
- p.Glu98= Single submitter agammaglobulinemia 6, autosomal recessive
- p.Gly135= Single submitter agammaglobulinemia 6, autosomal recessive
- p.Gly160= Single submitter agammaglobulinemia 6, autosomal recessive
- p.Gly189= Single submitter agammaglobulinemia 6, autosomal recessive
- p.Gly216= Single submitter agammaglobulinemia 6, autosomal recessive
- p.Gly223= Single submitter agammaglobulinemia 6, autosomal recessive
- p.Gly40= Single submitter agammaglobulinemia 6, autosomal recessive
- p.Gly72Ser Single submitter ⚠
- p.Gly94= Single submitter agammaglobulinemia 6, autosomal recessive
- p.His64= Single submitter agammaglobulinemia 6, autosomal recessive
- p.Ile174= Single submitter agammaglobulinemia 6, autosomal recessive
- p.Leu167= Single submitter agammaglobulinemia 6, autosomal recessive
- p.Lys219= Single submitter agammaglobulinemia 6, autosomal recessive
- p.Lys93= Single submitter agammaglobulinemia 6, autosomal recessive
- p.Phe121= Single submitter agammaglobulinemia 6, autosomal recessive
- p.Phe178= Single submitter agammaglobulinemia 6, autosomal recessive
- p.Pro226= Single submitter agammaglobulinemia 6, autosomal recessive
- p.Pro25= Single submitter agammaglobulinemia 6, autosomal recessive
- p.Pro8= Single submitter agammaglobulinemia 6, autosomal recessive
- p.Ser31= Single submitter agammaglobulinemia 6, autosomal recessive
- p.Ser44= Single submitter agammaglobulinemia 6, autosomal recessive
- p.Ser71= Single submitter agammaglobulinemia 6, autosomal recessive
- p.Ser75= Single submitter agammaglobulinemia 6, autosomal recessive
- p.Thr106= Single submitter agammaglobulinemia 6, autosomal recessive
- p.Thr129= Single submitter agammaglobulinemia 6, autosomal recessive
- p.Thr156= Single submitter agammaglobulinemia 6, autosomal recessive
- p.Thr166= Single submitter agammaglobulinemia 6, autosomal recessive
- p.Thr195= Single submitter agammaglobulinemia 6, autosomal recessive
- p.Thr212= Single submitter agammaglobulinemia 6, autosomal recessive
- p.Thr215= Single submitter agammaglobulinemia 6, autosomal recessive
- p.Thr60= Single submitter agammaglobulinemia 6, autosomal recessive
- p.Tyr196= Single submitter agammaglobulinemia 6, autosomal recessive
- p.Tyr207= Single submitter agammaglobulinemia 6, autosomal recessive
- p.Tyr35= Single submitter agammaglobulinemia 6, autosomal recessive
- c.-8C>T No assertion criteria CD79B-related disorder
Uncertain significance 61
- p.Ala5Val Multiple submitters agammaglobulinemia 6, autosomal recessive ⚠
- p.Arg36Trp Multiple submitters agammaglobulinemia 6, autosomal recessive ⚠
- p.Gly216Arg Multiple submitters agammaglobulinemia 6, autosomal recessive ⚠
- p.Leu91Pro Multiple submitters agammaglobulinemia 6, autosomal recessive ⚠
- p.Val175Met Multiple submitters CD79B-related disorder ⚠
- c.118+3C>T Single submitter agammaglobulinemia 6, autosomal recessive
- c.431-8_431-7delinsTG Single submitter agammaglobulinemia 6, autosomal recessive
- c.591+4A>T Single submitter agammaglobulinemia 6, autosomal recessive
- c.67+3A>G Single submitter agammaglobulinemia 6, autosomal recessive
- p.Ala16Val Single submitter agammaglobulinemia 6, autosomal recessive ⚠
- p.Ala188Gly Single submitter agammaglobulinemia 6, autosomal recessive
- p.Ala188Pro Single submitter agammaglobulinemia 6, autosomal recessive ⚠
- p.Ala42Thr Single submitter agammaglobulinemia 6, autosomal recessive ⚠
- p.Ala54Thr Single submitter agammaglobulinemia 6, autosomal recessive ⚠
- p.Ala70Thr Single submitter agammaglobulinemia 6, autosomal recessive ⚠
- p.Arg141Gln Single submitter agammaglobulinemia 6, autosomal recessive ⚠
- p.Arg214Gln Single submitter agammaglobulinemia 6, autosomal recessive ⚠
- p.Arg34Gln Single submitter ⚠
- p.Arg34Pro Single submitter ⚠
- p.Arg51His Single submitter agammaglobulinemia 6, autosomal recessive ⚠
- p.Arg57Pro Single submitter agammaglobulinemia 6, autosomal recessive ⚠
- p.Asn127Asp Single submitter agammaglobulinemia 6, autosomal recessive ⚠
- p.Asn37His Single submitter ⚠
- p.Asn73Asp Single submitter agammaglobulinemia 6, autosomal recessive ⚠
- p.Asn73Thr Single submitter agammaglobulinemia 6, autosomal recessive ⚠
- p.Asp184Glu Single submitter agammaglobulinemia 6, autosomal recessive ⚠
- p.Cys122del Single submitter agammaglobulinemia 6, autosomal recessive
- p.Gln100Arg Single submitter agammaglobulinemia 6, autosomal recessive ⚠
- p.Gln110Arg Single submitter agammaglobulinemia 6, autosomal recessive ⚠
- p.Gln203Lys Single submitter ⚠
- p.Glu102Lys Single submitter agammaglobulinemia 6, autosomal recessive ⚠
- p.Glu191Gln Single submitter agammaglobulinemia 6, autosomal recessive ⚠
- p.Glu197= Single submitter agammaglobulinemia 6, autosomal recessive
- p.Glu197Gln Single submitter ⚠
- p.Glu32del Single submitter agammaglobulinemia 6, autosomal recessive
- p.Glu32Gln Single submitter agammaglobulinemia 6, autosomal recessive ⚠
- p.Glu98Lys Single submitter ⚠
- p.Gly227Ser Single submitter agammaglobulinemia 6, autosomal recessive ⚠
- p.Ile162Val Single submitter ⚠
- p.Leu181Gln Single submitter agammaglobulinemia 6, autosomal recessive ⚠
- p.Lys183Glu Single submitter agammaglobulinemia 6, autosomal recessive ⚠
- p.Met143Ile Single submitter agammaglobulinemia 6, autosomal recessive ⚠
- p.Met82Arg Single submitter agammaglobulinemia 6, autosomal recessive ⚠
- p.Met82Val Single submitter ⚠
- p.Met96Val Single submitter agammaglobulinemia 6, autosomal recessive ⚠
- p.Phe114Cys Single submitter agammaglobulinemia 6, autosomal recessive ⚠
- p.Phe121Cys Single submitter agammaglobulinemia 6, autosomal recessive ⚠
- p.Pro38Ser Single submitter ⚠
- p.Pro86Thr Single submitter agammaglobulinemia 6, autosomal recessive ⚠
- p.Ser186Asn Single submitter agammaglobulinemia 6, autosomal recessive ⚠
- p.Ser31Trp Single submitter agammaglobulinemia 6, autosomal recessive ⚠
- p.Ser44Leu Single submitter agammaglobulinemia 6, autosomal recessive ⚠
- p.Ser69Gly Single submitter agammaglobulinemia 6, autosomal recessive ⚠
- p.Thr106Ile Single submitter ⚠
- p.Thr108Ile Single submitter agammaglobulinemia 6, autosomal recessive ⚠
- p.Thr156Met Single submitter agammaglobulinemia 6, autosomal recessive ⚠
- p.Thr166Met Single submitter agammaglobulinemia 6, autosomal recessive ⚠
- p.Thr195Ser Single submitter agammaglobulinemia 6, autosomal recessive ⚠
- p.Thr212Met Single submitter agammaglobulinemia 6, autosomal recessive ⚠
- p.Val222Ile Single submitter agammaglobulinemia 6, autosomal recessive ⚠
- p.Val222Leu Single submitter ⚠