CD82 — 46 ClinVar variants
All ClinVar germline CD82 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 42 flagged for review →
3 Benign · 2 Likely benign · 41 Uncertain significance
Full CD82 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 42
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 26
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CD82 p.Ala195Val Uncertain significance Single submitter
- CD82 p.Arg53Ser Uncertain significance Single submitter
- CD82 p.Asn109Ser Uncertain significance Single submitter
- CD82 p.Asn227Thr Uncertain significance Single submitter
- CD82 p.Asp138Asn Uncertain significance Single submitter
- CD82 p.Cys176Arg Uncertain significance Single submitter
- CD82 p.Gln146Glu Uncertain significance Single submitter
- CD82 p.Glu194Lys Uncertain significance Single submitter
- CD82 p.Glu218Gly Uncertain significance Single submitter
- CD82 p.Glu242Lys Uncertain significance Single submitter
- CD82 p.Gly203Val Uncertain significance Single submitter
- CD82 p.Gly31Arg Uncertain significance Single submitter
- CD82 p.Gly70Ser Uncertain significance Single submitter
- CD82 p.Gly76Ser Uncertain significance Single submitter
- CD82 p.His205Gln Uncertain significance Single submitter
- CD82 p.Ile125Phe Uncertain significance Single submitter
- CD82 p.Ile231Val Uncertain significance Single submitter
- CD82 p.Ile250Val Uncertain significance Single submitter
- CD82 p.Ile42Val Uncertain significance Single submitter
- CD82 p.Leu124Phe Uncertain significance Single submitter
- CD82 p.Met165Arg Uncertain significance Single submitter
- CD82 p.Met217Ile Uncertain significance Single submitter
- CD82 p.Pro173Ser Uncertain significance Single submitter
- CD82 p.Thr47Ser Uncertain significance Single submitter
- CD82 p.Val121Met Uncertain significance Single submitter
- CD82 p.Val44Ile Uncertain significance Single submitter
Predictors split 16
The independent predictors disagree with each other — read with care.
- CD82 p.Arg254Trp Uncertain significance Single submitter
- CD82 p.Asn17Ser Uncertain significance Single submitter
- CD82 p.Glu177Lys Likely benign Single submitter
- CD82 p.Leu105Phe Uncertain significance Single submitter
- CD82 p.Met69Leu Uncertain significance Single submitter
- CD82 p.Pro265Leu Uncertain significance Single submitter
- CD82 p.Pro265Ser Uncertain significance Single submitter
- CD82 p.Ser154Gly Uncertain significance Single submitter
- CD82 p.Tyr156Cys Uncertain significance Single submitter
- CD82 p.Tyr267Cys Uncertain significance Single submitter
- CD82 p.Tyr57His Uncertain significance Single submitter
- CD82 p.Val100Met Uncertain significance Single submitter
- CD82 p.Val143Met Uncertain significance Single submitter
- CD82 p.Val234Leu Uncertain significance Single submitter
- CD82 p.Val247Leu Likely benign Single submitter
- CD82 p.Val32Ala Uncertain significance Single submitter
All CD82 variants
Likely benign 2
- p.Glu177Lys Single submitter ⚠
- p.Val247Leu Single submitter ⚠
Uncertain significance 41
- p.Ala195Val Single submitter ⚠
- p.Arg254Trp Single submitter ⚠
- p.Arg53Ser Single submitter ⚠
- p.Asn109Ser Single submitter ⚠
- p.Asn17Ser Single submitter ⚠
- p.Asn227Thr Single submitter ⚠
- p.Asp138Asn Single submitter ⚠
- p.Cys176Arg Single submitter ⚠
- p.Cys193= Single submitter
- p.Gln146Glu Single submitter ⚠
- p.Glu194Lys Single submitter ⚠
- p.Glu218Gly Single submitter ⚠
- p.Glu242Lys Single submitter ⚠
- p.Gly203Val Single submitter ⚠
- p.Gly31Arg Single submitter ⚠
- p.Gly70Ser Single submitter ⚠
- p.Gly76Ser Single submitter ⚠
- p.His205Gln Single submitter ⚠
- p.Ile125Phe Single submitter ⚠
- p.Ile231Val Single submitter ⚠
- p.Ile250Val Single submitter ⚠
- p.Ile42Val Single submitter ⚠
- p.Leu105Phe Single submitter ⚠
- p.Leu124Phe Single submitter ⚠
- p.Met165Arg Single submitter ⚠
- p.Met217Ile Single submitter ⚠
- p.Met69Leu Single submitter ⚠
- p.Pro173Ser Single submitter ⚠
- p.Pro265Leu Single submitter ⚠
- p.Pro265Ser Single submitter ⚠
- p.Ser154Gly Single submitter ⚠
- p.Thr47Ser Single submitter ⚠
- p.Tyr156Cys Single submitter ⚠
- p.Tyr267Cys Single submitter ⚠
- p.Tyr57His Single submitter ⚠
- p.Val100Met Single submitter ⚠
- p.Val121Met Single submitter ⚠
- p.Val143Met Single submitter ⚠
- p.Val234Leu Single submitter ⚠
- p.Val32Ala Single submitter ⚠
- p.Val44Ile Single submitter ⚠