CD83 — 32 ClinVar variants
All ClinVar germline CD83 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 30 flagged for review →
1 Benign · 1 Likely benign · 30 Uncertain significance
Full CD83 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 30
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 21
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CD83 p.Ala143Val Uncertain significance Single submitter
- CD83 p.Ala84Ser Uncertain significance Single submitter
- CD83 p.Ala84Thr Uncertain significance Single submitter
- CD83 p.Arg167Gln Uncertain significance Single submitter
- CD83 p.Asn191Asp Uncertain significance Single submitter
- CD83 p.Asn79His Uncertain significance Single submitter
- CD83 p.Asn79Ile Uncertain significance Single submitter
- CD83 p.Asp66Tyr Uncertain significance Single submitter
- CD83 p.Gln42Arg Uncertain significance Single submitter
- CD83 p.Glu181Lys Uncertain significance Single submitter
- CD83 p.Glu203Gln Uncertain significance Single submitter
- CD83 p.His72Arg Uncertain significance Single submitter
- CD83 p.Ile145Val Uncertain significance Single submitter
- CD83 p.Ile171Val Uncertain significance Single submitter
- CD83 p.Lys177Glu Uncertain significance Single submitter
- CD83 p.Pro112Ser Uncertain significance Single submitter
- CD83 p.Pro199Ser Uncertain significance Single submitter
- CD83 p.Ser170Gly Uncertain significance Single submitter
- CD83 p.Ser2Leu Uncertain significance Single submitter
- CD83 p.Thr98Ala Uncertain significance Single submitter
- CD83 p.Tyr141Cys Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- CD83 p.Asp30Asn Uncertain significance Single submitter
- CD83 p.Asp40Tyr Uncertain significance Single submitter
- CD83 p.Glu22Lys Uncertain significance Single submitter
- CD83 p.Gly120Asp Uncertain significance Single submitter
- CD83 p.Gly55Asp Uncertain significance Single submitter
- CD83 p.Pro21Ser Uncertain significance Single submitter
- CD83 p.Pro89Ser Uncertain significance Single submitter
- CD83 p.Thr162Ile Uncertain significance Single submitter
- CD83 p.Val122Leu Uncertain significance Single submitter
All CD83 variants
Benign 1
- p.Arg182Gln Single submitter
Likely benign 1
- p.Arg95Gln Single submitter
Uncertain significance 30
- p.Ala143Val Single submitter ⚠
- p.Ala84Ser Single submitter ⚠
- p.Ala84Thr Single submitter ⚠
- p.Arg167Gln Single submitter ⚠
- p.Asn191Asp Single submitter ⚠
- p.Asn79His Single submitter ⚠
- p.Asn79Ile Single submitter ⚠
- p.Asp30Asn Single submitter ⚠
- p.Asp40Tyr Single submitter ⚠
- p.Asp66Tyr Single submitter ⚠
- p.Gln42Arg Single submitter ⚠
- p.Glu181Lys Single submitter ⚠
- p.Glu203Gln Single submitter ⚠
- p.Glu22Lys Single submitter ⚠
- p.Gly120Asp Single submitter ⚠
- p.Gly55Asp Single submitter ⚠
- p.His72Arg Single submitter ⚠
- p.Ile145Val Single submitter ⚠
- p.Ile171Val Single submitter ⚠
- p.Lys177Glu Single submitter ⚠
- p.Pro112Ser Single submitter ⚠
- p.Pro199Ser Single submitter ⚠
- p.Pro21Ser Single submitter ⚠
- p.Pro89Ser Single submitter ⚠
- p.Ser170Gly Single submitter ⚠
- p.Ser2Leu Single submitter ⚠
- p.Thr162Ile Single submitter ⚠
- p.Thr98Ala Single submitter ⚠
- p.Tyr141Cys Single submitter ⚠
- p.Val122Leu Single submitter ⚠