CD8B — 31 ClinVar variants
All ClinVar germline CD8B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 26 flagged for review →
5 Likely benign · 26 Uncertain significance
Full CD8B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 26
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 17
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CD8B p.Ala190Thr Uncertain significance Single submitter
- CD8B p.Ala60Thr Uncertain significance Single submitter
- CD8B p.Arg201Gln Uncertain significance Single submitter
- CD8B p.Arg98Gln Uncertain significance Single submitter
- CD8B p.Arg98Leu Uncertain significance Single submitter
- CD8B p.Gln23Lys Uncertain significance Single submitter
- CD8B p.Glu161Asp Uncertain significance Single submitter
- CD8B p.Glu161Gly Uncertain significance Single submitter
- CD8B p.Glu42Lys Uncertain significance Single submitter
- CD8B p.Gly120Arg Uncertain significance Single submitter
- CD8B p.Gly127Arg Uncertain significance Single submitter
- CD8B p.Gly127Val Uncertain significance Single submitter
- CD8B p.Leu157Val Uncertain significance Single submitter
- CD8B p.Pro170Ala Uncertain significance Single submitter
- CD8B p.Pro61Ser Uncertain significance Single submitter
- CD8B p.Ser111Arg Uncertain significance Single submitter
- CD8B p.Ser20Leu Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- CD8B p.Arg156Trp Uncertain significance Single submitter
- CD8B p.Arg203Cys Uncertain significance Single submitter
- CD8B p.Arg51His Uncertain significance Single submitter
- CD8B p.Leu183Pro Uncertain significance Single submitter
- CD8B p.Leu5Met Uncertain significance Single submitter
- CD8B p.Lys152Asn Uncertain significance Single submitter
- CD8B p.Met117Thr Uncertain significance Single submitter
- CD8B p.Phe93Leu Uncertain significance Single submitter
- CD8B p.Ser40Phe Uncertain significance Single submitter
All CD8B variants
Likely benign 5
- p.Gln220Arg Single submitter
- p.Ile45Thr Single submitter
- p.Pro166Leu Single submitter
- p.Val119Ile Single submitter
- p.Val218= Single submitter
Uncertain significance 26
- p.Ala190Thr Single submitter ⚠
- p.Ala60Thr Single submitter ⚠
- p.Arg156Trp Single submitter ⚠
- p.Arg201Gln Single submitter ⚠
- p.Arg203Cys Single submitter ⚠
- p.Arg51His Single submitter ⚠
- p.Arg98Gln Single submitter ⚠
- p.Arg98Leu Single submitter ⚠
- p.Gln23Lys Single submitter ⚠
- p.Glu161Asp Single submitter ⚠
- p.Glu161Gly Single submitter ⚠
- p.Glu42Lys Single submitter ⚠
- p.Gly120Arg Single submitter ⚠
- p.Gly127Arg Single submitter ⚠
- p.Gly127Val Single submitter ⚠
- p.Leu157Val Single submitter ⚠
- p.Leu183Pro Single submitter ⚠
- p.Leu5Met Single submitter ⚠
- p.Lys152Asn Single submitter ⚠
- p.Met117Thr Single submitter ⚠
- p.Phe93Leu Single submitter ⚠
- p.Pro170Ala Single submitter ⚠
- p.Pro61Ser Single submitter ⚠
- p.Ser111Arg Single submitter ⚠
- p.Ser20Leu Single submitter ⚠
- p.Ser40Phe Single submitter ⚠