CD9 — 11 ClinVar variants
All ClinVar germline CD9 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 8 flagged for review →
3 Benign · 8 Uncertain significance
Full CD9 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 8
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 7
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CD9 p.Asn51Thr Uncertain significance Single submitter
- CD9 p.Glu103Gln Uncertain significance Single submitter
- CD9 p.Gly210Ala Uncertain significance Single submitter
- CD9 p.Gly80Arg Uncertain significance Single submitter
- CD9 p.Leu96Phe Uncertain significance Single submitter
- CD9 p.Met227Leu Uncertain significance Single submitter
- CD9 p.Met70Ile Uncertain significance Single submitter
Predictors split 1
The independent predictors disagree with each other — read with care.
All CD9 variants
Benign 3
- c.447+8G>A Multiple submitters
- c.349-9C>G Single submitter
- p.Leu76= Single submitter
Uncertain significance 8
- p.Asn51Thr Single submitter ⚠
- p.Glu103Gln Single submitter ⚠
- p.Gly210Ala Single submitter ⚠
- p.Gly80Arg Single submitter ⚠
- p.Leu96Phe Single submitter ⚠
- p.Lys186Glu Single submitter ⚠
- p.Met227Leu Single submitter ⚠
- p.Met70Ile Single submitter ⚠