CDA — 11 ClinVar variants
All ClinVar germline CDA variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 9 flagged for review →
2 Benign · 9 Uncertain significance
Full CDA gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 9
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 3
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 6
The independent predictors disagree with each other — read with care.
- CDA p.Gln92His Uncertain significance Single submitter
- CDA p.Ile87Leu Uncertain significance Single submitter
- CDA p.Met117Ile Uncertain significance Single submitter
- CDA p.Pro120Leu Uncertain significance Single submitter
- CDA p.Thr123Met Uncertain significance Single submitter
- CDA p.Thr128Met Uncertain significance Single submitter
All CDA variants
Uncertain significance 9
- p.Gln92His Single submitter ⚠
- p.Gly39Ala Single submitter ⚠
- p.Ile87Leu Single submitter ⚠
- p.Ile96Val Single submitter ⚠
- p.Met117Ile Single submitter ⚠
- p.Pro120Leu Single submitter ⚠
- p.Thr123Met Single submitter ⚠
- p.Thr128Met Single submitter ⚠
- p.Thr128Ser Single submitter ⚠