CDADC1 — 46 ClinVar variants
All ClinVar germline CDADC1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 44 flagged for review →
4 Likely benign · 42 Uncertain significance
Full CDADC1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 44
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 31
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CDADC1 p.Gly119Glu Uncertain significance Multiple submitters
- CDADC1 p.Ala110Thr Uncertain significance Single submitter
- CDADC1 p.Arg17Pro Uncertain significance Single submitter
- CDADC1 p.Arg300His Uncertain significance Single submitter
- CDADC1 p.Asn247Ser Uncertain significance Single submitter
- CDADC1 p.Cys137Gly Uncertain significance Single submitter
- CDADC1 p.Cys231Arg Uncertain significance Single submitter
- CDADC1 p.Cys426Ser Uncertain significance Single submitter
- CDADC1 p.Gln409Arg Uncertain significance Single submitter
- CDADC1 p.Gln440His Uncertain significance Single submitter
- CDADC1 p.Glu106Lys Uncertain significance Single submitter
- CDADC1 p.Glu249Asp Uncertain significance Single submitter
- CDADC1 p.Gly111Arg Uncertain significance Single submitter
- CDADC1 p.Gly348Ala Uncertain significance Single submitter
- CDADC1 p.Gly461Arg Uncertain significance Single submitter
- CDADC1 p.Gly512Arg Uncertain significance Single submitter
- CDADC1 p.His187Arg Uncertain significance Single submitter
- CDADC1 p.His66Arg Uncertain significance Single submitter
- CDADC1 p.Ile141Ser Uncertain significance Single submitter
- CDADC1 p.Ile30Val Uncertain significance Single submitter
- CDADC1 p.Lys171Arg Uncertain significance Single submitter
- CDADC1 p.Met199Val Uncertain significance Single submitter
- CDADC1 p.Met256Val Uncertain significance Single submitter
- CDADC1 p.Met26Leu Uncertain significance Single submitter
- CDADC1 p.Ser313Asn Uncertain significance Single submitter
- CDADC1 p.Ser456Phe Uncertain significance Single submitter
- CDADC1 p.Thr162Met Uncertain significance Single submitter
- CDADC1 p.Thr225Asn Uncertain significance Single submitter
- CDADC1 p.Tyr229Phe Uncertain significance Single submitter
- CDADC1 p.Val19Ile Uncertain significance Single submitter
- CDADC1 p.Val448Leu Uncertain significance Single submitter
Predictors split 13
The independent predictors disagree with each other — read with care.
- CDADC1 p.Arg273Ser Uncertain significance Single submitter
- CDADC1 p.Arg332Gln Uncertain significance Single submitter
- CDADC1 p.Arg510Cys Likely benign Single submitter
- CDADC1 p.Arg510His Uncertain significance Single submitter
- CDADC1 p.Gln112Lys Likely benign Single submitter
- CDADC1 p.Glu502Val Uncertain significance Single submitter
- CDADC1 p.His504Tyr Uncertain significance Single submitter
- CDADC1 p.Leu161Pro Uncertain significance Single submitter
- CDADC1 p.Lys386Asn Uncertain significance Single submitter
- CDADC1 p.Lys439Asn Uncertain significance Single submitter
- CDADC1 p.Phe212Ile Uncertain significance Single submitter
- CDADC1 p.Pro291Leu Uncertain significance Single submitter
- CDADC1 p.Tyr239Cys Uncertain significance Single submitter
All CDADC1 variants
Likely benign 4
- p.Arg300Cys Single submitter
- p.Arg407= Single submitter
- p.Arg510Cys Single submitter ⚠
- p.Gln112Lys Single submitter ⚠
Uncertain significance 42
- p.Gly119Glu Multiple submitters ⚠
- p.Ala110Thr Single submitter ⚠
- p.Arg17Pro Single submitter ⚠
- p.Arg273Ser Single submitter ⚠
- p.Arg300His Single submitter ⚠
- p.Arg332Gln Single submitter ⚠
- p.Arg510His Single submitter ⚠
- p.Asn247Ser Single submitter ⚠
- p.Cys137Gly Single submitter ⚠
- p.Cys231Arg Single submitter ⚠
- p.Cys426Ser Single submitter ⚠
- p.Gln409Arg Single submitter ⚠
- p.Gln440His Single submitter ⚠
- p.Glu106Lys Single submitter ⚠
- p.Glu249Asp Single submitter ⚠
- p.Glu502Val Single submitter ⚠
- p.Gly111Arg Single submitter ⚠
- p.Gly348Ala Single submitter ⚠
- p.Gly461Arg Single submitter ⚠
- p.Gly512Arg Single submitter ⚠
- p.His187Arg Single submitter ⚠
- p.His504Tyr Single submitter ⚠
- p.His66Arg Single submitter ⚠
- p.Ile141Ser Single submitter ⚠
- p.Ile30Val Single submitter ⚠
- p.Leu161Pro Single submitter ⚠
- p.Lys171Arg Single submitter ⚠
- p.Lys386Asn Single submitter ⚠
- p.Lys439Asn Single submitter ⚠
- p.Met199Val Single submitter ⚠
- p.Met256Val Single submitter ⚠
- p.Met26Leu Single submitter ⚠
- p.Phe212Ile Single submitter ⚠
- p.Pro291Leu Single submitter ⚠
- p.Ser313Asn Single submitter ⚠
- p.Ser456Phe Single submitter ⚠
- p.Thr162Met Single submitter ⚠
- p.Thr225Asn Single submitter ⚠
- p.Tyr229Phe Single submitter ⚠
- p.Tyr239Cys Single submitter ⚠
- p.Val19Ile Single submitter ⚠
- p.Val448Leu Single submitter ⚠