CDC14B — 63 ClinVar variants
All ClinVar germline CDC14B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 62 flagged for review →
2 Likely benign · 61 Uncertain significance
Full CDC14B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 62
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 33
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CDC14B p.Ala13Thr Uncertain significance Single submitter
- CDC14B p.Ala13Val Uncertain significance Single submitter
- CDC14B p.Ala14Ser Uncertain significance Single submitter
- CDC14B p.Ala286Val Uncertain significance Single submitter
- CDC14B p.Ala388Val Uncertain significance Single submitter
- CDC14B p.Ala95Val Uncertain significance Single submitter
- CDC14B p.Arg266Lys Uncertain significance Single submitter
- CDC14B p.Arg320His Uncertain significance Single submitter
- CDC14B p.Arg498His Uncertain significance Single submitter
- CDC14B p.Asn423Ser Uncertain significance Single submitter
- CDC14B p.Asp279Asn Uncertain significance Single submitter
- CDC14B p.Asp301Tyr Uncertain significance Single submitter
- CDC14B p.Cys17Arg Uncertain significance Single submitter
- CDC14B p.Cys182Tyr Uncertain significance Single submitter
- CDC14B p.Gln36His Uncertain significance Single submitter
- CDC14B p.Gln410His Uncertain significance Single submitter
- CDC14B p.Gly27Ala Uncertain significance Single submitter
- CDC14B p.His281Arg Uncertain significance Single submitter
- CDC14B p.Ile111Val Uncertain significance Single submitter
- CDC14B p.Ile329Val Uncertain significance Single submitter
- CDC14B p.Leu108Phe Uncertain significance Single submitter
- CDC14B p.Leu108Ser Uncertain significance Single submitter
- CDC14B p.Lys271Arg Uncertain significance Single submitter
- CDC14B p.Lys29Arg Uncertain significance Single submitter
- CDC14B p.Lys392Thr Uncertain significance Single submitter
- CDC14B p.Lys494Glu Uncertain significance Single submitter
- CDC14B p.Pro16Arg Uncertain significance Single submitter
- CDC14B p.Pro26Ala Uncertain significance Single submitter
- CDC14B p.Ser124Cys Uncertain significance Single submitter
- CDC14B p.Ser5Thr Uncertain significance Single submitter
- CDC14B p.Thr340Ala Uncertain significance Single submitter
- CDC14B p.Thr460Ile Uncertain significance Single submitter
- CDC14B p.Tyr139Cys Uncertain significance Single submitter
Predictors split 29
The independent predictors disagree with each other — read with care.
- CDC14B p.Ala87Thr Uncertain significance Single submitter
- CDC14B p.Arg272His Uncertain significance Single submitter
- CDC14B p.Arg375His Uncertain significance Single submitter
- CDC14B p.Asn198Ser Uncertain significance Single submitter
- CDC14B p.Asn213His Uncertain significance Single submitter
- CDC14B p.Asn256Ser Likely benign Single submitter
- CDC14B p.Asn93Ser Uncertain significance Single submitter
- CDC14B p.Asp293Asn Uncertain significance Single submitter
- CDC14B p.Gln242Lys Uncertain significance Single submitter
- CDC14B p.Glu414Ala Uncertain significance Single submitter
- CDC14B p.Glu414Lys Uncertain significance Single submitter
- CDC14B p.Gly384Arg Uncertain significance Single submitter
- CDC14B p.Gly404Arg Uncertain significance Single submitter
- CDC14B p.His207Arg Uncertain significance Single submitter
- CDC14B p.Ile220Met Uncertain significance Single submitter
- CDC14B p.Ile249Val Uncertain significance Single submitter
- CDC14B p.Ile52Val Uncertain significance Single submitter
- CDC14B p.Leu393Phe Uncertain significance Single submitter
- CDC14B p.Lys253Glu Uncertain significance Single submitter
- CDC14B p.Lys30Glu Uncertain significance Single submitter
- CDC14B p.Met96Val Uncertain significance Single submitter
- CDC14B p.Pro16His Uncertain significance Single submitter
- CDC14B p.Ser172Gly Uncertain significance Single submitter
- CDC14B p.Ser23Trp Uncertain significance Single submitter
- CDC14B p.Ser34Phe Uncertain significance Single submitter
- CDC14B p.Ser483Arg Uncertain significance Single submitter
- CDC14B p.Thr290Ile Uncertain significance Single submitter
- CDC14B p.Thr292Ala Uncertain significance Single submitter
- CDC14B p.Tyr208Cys Uncertain significance Single submitter
All CDC14B variants
Likely benign 2
- p.Asn256Ser Single submitter ⚠
- p.Lys379Arg Single submitter
Uncertain significance 61
- p.Ala13Thr Single submitter ⚠
- p.Ala13Val Single submitter ⚠
- p.Ala14Ser Single submitter ⚠
- p.Ala286Val Single submitter ⚠
- p.Ala388Val Single submitter ⚠
- p.Ala87Thr Single submitter ⚠
- p.Ala95Val Single submitter ⚠
- p.Arg266Lys Single submitter ⚠
- p.Arg272His Single submitter ⚠
- p.Arg320His Single submitter ⚠
- p.Arg375His Single submitter ⚠
- p.Arg498His Single submitter ⚠
- p.Asn198Ser Single submitter ⚠
- p.Asn213His Single submitter ⚠
- p.Asn423Ser Single submitter ⚠
- p.Asn93Ser Single submitter ⚠
- p.Asp279Asn Single submitter ⚠
- p.Asp293Asn Single submitter ⚠
- p.Asp301Tyr Single submitter ⚠
- p.Cys17Arg Single submitter ⚠
- p.Cys182Tyr Single submitter ⚠
- p.Gln242Lys Single submitter ⚠
- p.Gln36His Single submitter ⚠
- p.Gln410His Single submitter ⚠
- p.Glu414Ala Single submitter ⚠
- p.Glu414Lys Single submitter ⚠
- p.Gly27Ala Single submitter ⚠
- p.Gly384Arg Single submitter ⚠
- p.Gly404Arg Single submitter ⚠
- p.His207Arg Single submitter ⚠
- p.His281Arg Single submitter ⚠
- p.Ile111Val Single submitter ⚠
- p.Ile220Met Single submitter ⚠
- p.Ile249Val Single submitter ⚠
- p.Ile329Val Single submitter ⚠
- p.Ile52Val Single submitter ⚠
- p.Leu108Phe Single submitter ⚠
- p.Leu108Ser Single submitter ⚠
- p.Leu393Phe Single submitter ⚠
- p.Lys253Glu Single submitter ⚠
- p.Lys271Arg Single submitter ⚠
- p.Lys29Arg Single submitter ⚠
- p.Lys30Glu Single submitter ⚠
- p.Lys392Thr Single submitter ⚠
- p.Lys494Glu Single submitter ⚠
- p.Met96Val Single submitter ⚠
- p.Pro16Arg Single submitter ⚠
- p.Pro16His Single submitter ⚠
- p.Pro26Ala Single submitter ⚠
- p.Ser124Cys Single submitter ⚠
- p.Ser172Gly Single submitter ⚠
- p.Ser23Trp Single submitter ⚠
- p.Ser34Phe Single submitter ⚠
- p.Ser483Arg Single submitter ⚠
- p.Ser5Thr Single submitter ⚠
- p.Thr290Ile Single submitter ⚠
- p.Thr292Ala Single submitter ⚠
- p.Thr340Ala Single submitter ⚠
- p.Thr460Ile Single submitter ⚠
- p.Tyr139Cys Single submitter ⚠
- p.Tyr208Cys Single submitter ⚠