CDC16 — 75 ClinVar variants
All ClinVar germline CDC16 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 71 flagged for review →
1 Benign · 3 Likely benign · 71 Uncertain significance
Full CDC16 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 71
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 43
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CDC16 p.Ala142Thr Uncertain significance Single submitter
- CDC16 p.Ala319Thr Uncertain significance Single submitter
- CDC16 p.Ala479Ser Uncertain significance Single submitter
- CDC16 p.Ala51Thr Uncertain significance Single submitter
- CDC16 p.Ala536Ser Uncertain significance Single submitter
- CDC16 p.Arg202His Uncertain significance Single submitter
- CDC16 p.Arg240Thr Uncertain significance Single submitter
- CDC16 p.Arg34Gly Uncertain significance Single submitter
- CDC16 p.Arg61Gln Uncertain significance Single submitter
- CDC16 p.Asn195Asp Uncertain significance Single submitter
- CDC16 p.Asn279His Uncertain significance Single submitter
- CDC16 p.Gln198His Uncertain significance Single submitter
- CDC16 p.Gln470Arg Uncertain significance Single submitter
- CDC16 p.Glu111Lys Uncertain significance Single submitter
- CDC16 p.Glu199Asp Uncertain significance Single submitter
- CDC16 p.Glu577Gly Uncertain significance Single submitter
- CDC16 p.His264Arg Uncertain significance Single submitter
- CDC16 p.His314Gln Uncertain significance Single submitter
- CDC16 p.His342Leu Uncertain significance Single submitter
- CDC16 p.His86Tyr Uncertain significance Single submitter
- CDC16 p.Ile475Phe Uncertain significance Single submitter
- CDC16 p.Ile488Asn Uncertain significance Single submitter
- CDC16 p.Ile99Thr Uncertain significance Single submitter
- CDC16 p.Leu176Gln Uncertain significance Single submitter
- CDC16 p.Lys138Arg Uncertain significance Single submitter
- CDC16 p.Lys192Arg Uncertain significance Single submitter
- CDC16 p.Lys192Glu Uncertain significance Single submitter
- CDC16 p.Lys365Glu Uncertain significance Single submitter
- CDC16 p.Met552Val Uncertain significance Single submitter
- CDC16 p.Met615Val Uncertain significance Single submitter
- CDC16 p.Phe514Leu Uncertain significance Single submitter
- CDC16 p.Pro399Leu Uncertain significance Single submitter
- CDC16 p.Pro402Leu Uncertain significance Single submitter
- CDC16 p.Ser131Phe Uncertain significance Single submitter
- CDC16 p.Ser619Asn Uncertain significance Single submitter
- CDC16 p.Thr578Met Uncertain significance Single submitter
- CDC16 p.Thr589Ile Uncertain significance Single submitter
- CDC16 p.Thr620Met Uncertain significance Single submitter
- CDC16 p.Tyr243Cys Uncertain significance Single submitter
- CDC16 p.Tyr357Phe Uncertain significance Single submitter
- CDC16 p.Tyr501Cys Uncertain significance Single submitter
- CDC16 p.Tyr501Ser Uncertain significance Single submitter
- CDC16 p.Val234Ile Uncertain significance Single submitter
Predictors split 28
The independent predictors disagree with each other — read with care.
- CDC16 p.Ala44Gly Uncertain significance Single submitter
- CDC16 p.Ala57Thr Uncertain significance Single submitter
- CDC16 p.Asn207His Uncertain significance Single submitter
- CDC16 p.Asn382Ser Uncertain significance Single submitter
- CDC16 p.Asn478Tyr Uncertain significance Single submitter
- CDC16 p.Glu229Lys Uncertain significance Single submitter
- CDC16 p.Glu4Lys Uncertain significance Single submitter
- CDC16 p.Glu85Asp Uncertain significance Single submitter
- CDC16 p.Ile128Met Uncertain significance Single submitter
- CDC16 p.Ile132Val Uncertain significance Single submitter
- CDC16 p.Ile338Val Uncertain significance Single submitter
- CDC16 p.Ile485Val Uncertain significance Single submitter
- CDC16 p.Leu32His Uncertain significance Single submitter
- CDC16 p.Leu429Val Uncertain significance Single submitter
- CDC16 p.Leu49Met Uncertain significance Single submitter
- CDC16 p.Met258Thr Uncertain significance Single submitter
- CDC16 p.Met492Ile Uncertain significance Single submitter
- CDC16 p.Phe205Ser Uncertain significance Single submitter
- CDC16 p.Pro221Leu Uncertain significance Single submitter
- CDC16 p.Pro399Ala Uncertain significance Single submitter
- CDC16 p.Ser131Cys Uncertain significance Single submitter
- CDC16 p.Thr581Met Uncertain significance Single submitter
- CDC16 p.Thr613Ile Uncertain significance Single submitter
- CDC16 p.Tyr140Cys Uncertain significance Single submitter
- CDC16 p.Tyr251Cys Uncertain significance Single submitter
- CDC16 p.Tyr295Cys Uncertain significance Single submitter
- CDC16 p.Tyr333Cys Uncertain significance Single submitter
- CDC16 p.Val29Ile Uncertain significance Single submitter
All CDC16 variants
Benign 1
- p.Ile132= Multiple submitters
Likely benign 3
- p.Gln38Arg Single submitter
- p.Val256= Single submitter
- p.Val92Ile Single submitter
Uncertain significance 71
- p.Ala142Thr Single submitter ⚠
- p.Ala319Thr Single submitter ⚠
- p.Ala44Gly Single submitter ⚠
- p.Ala479Ser Single submitter ⚠
- p.Ala51Thr Single submitter ⚠
- p.Ala536Ser Single submitter ⚠
- p.Ala57Thr Single submitter ⚠
- p.Arg202His Single submitter ⚠
- p.Arg240Thr Single submitter ⚠
- p.Arg34Gly Single submitter ⚠
- p.Arg61Gln Single submitter ⚠
- p.Asn195Asp Single submitter ⚠
- p.Asn207His Single submitter ⚠
- p.Asn279His Single submitter ⚠
- p.Asn382Ser Single submitter ⚠
- p.Asn478Tyr Single submitter ⚠
- p.Gln198His Single submitter ⚠
- p.Gln470Arg Single submitter ⚠
- p.Glu111Lys Single submitter ⚠
- p.Glu199Asp Single submitter ⚠
- p.Glu229Lys Single submitter ⚠
- p.Glu4Lys Single submitter ⚠
- p.Glu577Gly Single submitter ⚠
- p.Glu85Asp Single submitter ⚠
- p.His264Arg Single submitter ⚠
- p.His314Gln Single submitter ⚠
- p.His342Leu Single submitter ⚠
- p.His86Tyr Single submitter ⚠
- p.Ile128Met Single submitter ⚠
- p.Ile132Val Single submitter ⚠
- p.Ile338Val Single submitter ⚠
- p.Ile475Phe Single submitter ⚠
- p.Ile485Val Single submitter ⚠
- p.Ile488Asn Single submitter ⚠
- p.Ile99Thr Single submitter ⚠
- p.Leu176Gln Single submitter ⚠
- p.Leu32His Single submitter ⚠
- p.Leu429Val Single submitter ⚠
- p.Leu49Met Single submitter ⚠
- p.Lys138Arg Single submitter ⚠
- p.Lys192Arg Single submitter ⚠
- p.Lys192Glu Single submitter ⚠
- p.Lys365Glu Single submitter ⚠
- p.Met258Thr Single submitter ⚠
- p.Met492Ile Single submitter ⚠
- p.Met552Val Single submitter ⚠
- p.Met615Val Single submitter ⚠
- p.Phe205Ser Single submitter ⚠
- p.Phe514Leu Single submitter ⚠
- p.Pro221Leu Single submitter ⚠
- p.Pro399Ala Single submitter ⚠
- p.Pro399Leu Single submitter ⚠
- p.Pro402Leu Single submitter ⚠
- p.Ser131Cys Single submitter ⚠
- p.Ser131Phe Single submitter ⚠
- p.Ser619Asn Single submitter ⚠
- p.Thr578Met Single submitter ⚠
- p.Thr581Met Single submitter ⚠
- p.Thr589Ile Single submitter ⚠
- p.Thr613Ile Single submitter ⚠
- p.Thr620Met Single submitter ⚠
- p.Tyr140Cys Single submitter ⚠
- p.Tyr243Cys Single submitter ⚠
- p.Tyr251Cys Single submitter ⚠
- p.Tyr295Cys Single submitter ⚠
- p.Tyr333Cys Single submitter ⚠
- p.Tyr357Phe Single submitter ⚠
- p.Tyr501Cys Single submitter ⚠
- p.Tyr501Ser Single submitter ⚠
- p.Val234Ile Single submitter ⚠
- p.Val29Ile Single submitter ⚠