CDC20 — 71 ClinVar variants
All ClinVar germline CDC20 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 58 flagged for review →
10 Pathogenic · 2 Likely pathogenic · 1 Benign · 1 Benign/Likely benign · 1 Likely benign · 56 Uncertain significance
Full CDC20 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 58
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors vs ClinVar 2
ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.
-
CDC20 p.Ala211Thr
Pathogenic
No assertion criteria
oocyte maturation defect 14
-
CDC20 p.Arg322Gln
Pathogenic
No assertion criteria
oocyte maturation defect 14
Predictors lean, ClinVar uncertain 29
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CDC20 p.Ala140Val Uncertain significance Single submitter
- CDC20 p.Ala242Val Uncertain significance Single submitter
- CDC20 p.Arg270Gln Uncertain significance Single submitter
- CDC20 p.Arg30Ser Uncertain significance Single submitter
- CDC20 p.Arg480Gln Uncertain significance Single submitter
- CDC20 p.Arg483Gln Uncertain significance Single submitter
- CDC20 p.Asn183Ser Uncertain significance Single submitter
- CDC20 p.Asn204Ser Uncertain significance Single submitter
- CDC20 p.Asn22Ser Uncertain significance Single submitter
- CDC20 p.Asn369Ser Uncertain significance Single submitter
- CDC20 p.Asp173His Uncertain significance Single submitter
- CDC20 p.Gln349Arg Uncertain significance Single submitter
- CDC20 p.Gly37Ser Uncertain significance Single submitter
- CDC20 p.His112Gln Uncertain significance Single submitter
- CDC20 p.His293Tyr Uncertain significance Single submitter
- CDC20 p.His308Tyr Uncertain significance Single submitter
- CDC20 p.His495Pro Uncertain significance Single submitter
- CDC20 p.Leu449Pro Uncertain significance Single submitter
- CDC20 p.Met451Val Uncertain significance Single submitter
- CDC20 p.Phe473Leu Uncertain significance Single submitter
- CDC20 p.Pro101Leu Uncertain significance Single submitter
- CDC20 p.Pro24Arg Uncertain significance Single submitter
- CDC20 p.Ser210Asn Uncertain significance Single submitter
- CDC20 p.Ser247Asn Uncertain significance Single submitter
- CDC20 p.Ser282Phe Uncertain significance Single submitter
- CDC20 p.Ser448Gly Uncertain significance Single submitter
- CDC20 p.Thr157Pro Uncertain significance Single submitter
- CDC20 p.Thr352Ser Uncertain significance Single submitter
- CDC20 p.Trp363Arg Uncertain significance Single submitter
Predictors split 27
The independent predictors disagree with each other — read with care.
- CDC20 p.Ala461Thr Uncertain significance Single submitter
- CDC20 p.Arg162Gly Uncertain significance Single submitter
- CDC20 p.Arg260Gln Uncertain significance Single submitter
- CDC20 p.Arg27Ser Uncertain significance Single submitter
- CDC20 p.Arg316Cys Uncertain significance Single submitter
- CDC20 p.Arg471Cys Uncertain significance Single submitter
- CDC20 p.Arg471Gly Uncertain significance Single submitter
- CDC20 p.Arg479Trp Uncertain significance Single submitter
- CDC20 p.Arg480Trp Uncertain significance Single submitter
- CDC20 p.Arg481Pro Uncertain significance Single submitter
- CDC20 p.Arg481Trp Uncertain significance Single submitter
- CDC20 p.Arg483Trp Uncertain significance Single submitter
- CDC20 p.Glu102Gln Uncertain significance Single submitter
- CDC20 p.Gly226Ala Uncertain significance Single submitter
- CDC20 p.Ile229Met Uncertain significance Single submitter
- CDC20 p.Met88Ile Uncertain significance Single submitter
- CDC20 p.Pro225Leu Uncertain significance Single submitter
- CDC20 p.Pro25Leu Uncertain significance Single submitter
- CDC20 p.Pro340Thr Uncertain significance Single submitter
- CDC20 p.Ser153Asn Uncertain significance Single submitter
- CDC20 p.Ser205Asn Uncertain significance Single submitter
- CDC20 p.Ser282Ala Uncertain significance Single submitter
- CDC20 p.Thr432Ile Uncertain significance Single submitter
- CDC20 p.Thr457Ile Uncertain significance Single submitter
- CDC20 p.Val358Ile Uncertain significance Single submitter
- CDC20 p.Val396Gly Uncertain significance Single submitter
- CDC20 p.Arg286Ser Uncertain significance No assertion criteria
All CDC20 variants
Pathogenic 10
- c.330+1G>A No assertion criteria oocyte maturation defect 14
- p.Ala211Thr No assertion criteria oocyte maturation defect 14 ⚠
- p.Ala391_Cys392insTer No assertion criteria oocyte maturation defect 14
- p.Arg182Ter No assertion criteria oocyte maturation defect 14
- p.Arg262Ter No assertion criteria oocyte maturation defect 14
- p.Arg322Gln No assertion criteria oocyte maturation defect 14 ⚠
- p.Arg322Ter No assertion criteria oocyte maturation defect 14
- p.Gly272fs No assertion criteria oocyte maturation defect 14
- p.Trp385Cys No assertion criteria oocyte maturation defect 14
- p.Tyr228Cys No assertion criteria oocyte maturation defect 14
Likely pathogenic 2
- c.556+1G>T Single submitter oocyte maturation defect 14
- p.Cys364Ter Single submitter oocyte maturation defect 14
Benign 1
- p.Glu484= Multiple submitters
Benign/Likely benign 1
- p.Val361Ile Multiple submitters
Likely benign 1
- p.Ile229Val Single submitter
Uncertain significance 56
- p.Ala140Val Single submitter ⚠
- p.Ala242Val Single submitter ⚠
- p.Ala461Thr Single submitter ⚠
- p.Arg162Gly Single submitter ⚠
- p.Arg260Gln Single submitter ⚠
- p.Arg270Gln Single submitter ⚠
- p.Arg27Ser Single submitter ⚠
- p.Arg30Ser Single submitter ⚠
- p.Arg316Cys Single submitter ⚠
- p.Arg471Cys Single submitter ⚠
- p.Arg471Gly Single submitter ⚠
- p.Arg479Trp Single submitter ⚠
- p.Arg480Gln Single submitter ⚠
- p.Arg480Trp Single submitter ⚠
- p.Arg481Pro Single submitter ⚠
- p.Arg481Trp Single submitter ⚠
- p.Arg483Gln Single submitter ⚠
- p.Arg483Trp Single submitter ⚠
- p.Asn183Ser Single submitter ⚠
- p.Asn204Ser Single submitter ⚠
- p.Asn22Ser Single submitter ⚠
- p.Asn369Ser Single submitter ⚠
- p.Asp173His Single submitter ⚠
- p.Gln349Arg Single submitter ⚠
- p.Glu102Gln Single submitter ⚠
- p.Gly226Ala Single submitter ⚠
- p.Gly37Ser Single submitter ⚠
- p.His112Gln Single submitter ⚠
- p.His293Tyr Single submitter ⚠
- p.His308Tyr Single submitter ⚠
- p.His495Pro Single submitter ⚠
- p.Ile229Met Single submitter ⚠
- p.Leu449Pro Single submitter ⚠
- p.Met451Val Single submitter ⚠
- p.Met88Ile Single submitter ⚠
- p.Phe473Leu Single submitter ⚠
- p.Pro101Leu Single submitter ⚠
- p.Pro225Leu Single submitter ⚠
- p.Pro24Arg Single submitter ⚠
- p.Pro25Leu Single submitter ⚠
- p.Pro340Thr Single submitter ⚠
- p.Ser153Asn Single submitter ⚠
- p.Ser205Asn Single submitter ⚠
- p.Ser210Asn Single submitter ⚠
- p.Ser247Asn Single submitter ⚠
- p.Ser282Ala Single submitter ⚠
- p.Ser282Phe Single submitter ⚠
- p.Ser448Gly Single submitter ⚠
- p.Thr157Pro Single submitter ⚠
- p.Thr352Ser Single submitter ⚠
- p.Thr432Ile Single submitter ⚠
- p.Thr457Ile Single submitter ⚠
- p.Trp363Arg Single submitter ⚠
- p.Val358Ile Single submitter ⚠
- p.Val396Gly Single submitter ⚠
- p.Arg286Ser No assertion criteria ⚠