CDC23 — 44 ClinVar variants
All ClinVar germline CDC23 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 40 flagged for review →
2 Benign · 2 Likely benign · 40 Uncertain significance
Full CDC23 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 40
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 26
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CDC23 p.Ala68Asp Uncertain significance Single submitter
- CDC23 p.Arg424Gln Uncertain significance Single submitter
- CDC23 p.Arg424Trp Uncertain significance Single submitter
- CDC23 p.Arg585His Uncertain significance Single submitter
- CDC23 p.Asn110His Uncertain significance Single submitter
- CDC23 p.Asn287Ser Uncertain significance Single submitter
- CDC23 p.Asn581Ser Uncertain significance Single submitter
- CDC23 p.Glu231Asp Uncertain significance Single submitter
- CDC23 p.Ile497Thr Uncertain significance Single submitter
- CDC23 p.Ile503Thr Uncertain significance Single submitter
- CDC23 p.Leu42His Uncertain significance Single submitter
- CDC23 p.Lys492Arg Uncertain significance Single submitter
- CDC23 p.Pro18Ser Uncertain significance Single submitter
- CDC23 p.Pro225Ala Uncertain significance Single submitter
- CDC23 p.Pro570Leu Uncertain significance Single submitter
- CDC23 p.Pro66Ser Uncertain significance Single submitter
- CDC23 p.Pro72Leu Uncertain significance Single submitter
- CDC23 p.Pro73Ala Uncertain significance Single submitter
- CDC23 p.Pro73Leu Uncertain significance Single submitter
- CDC23 p.Ser121Tyr Uncertain significance Single submitter
- CDC23 p.Ser594Pro Uncertain significance Single submitter
- CDC23 p.Thr564Ala Uncertain significance Single submitter
- CDC23 p.Trp203Gly Uncertain significance Single submitter
- CDC23 p.Tyr115Cys Uncertain significance Single submitter
- CDC23 p.Val504Leu Uncertain significance Single submitter
- CDC23 p.Val96Ile Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- CDC23 p.Asn23Tyr Uncertain significance Single submitter
- CDC23 p.Cys532Phe Uncertain significance Single submitter
- CDC23 p.Gly108Ser Uncertain significance Single submitter
- CDC23 p.His162Arg Uncertain significance Single submitter
- CDC23 p.Ile255Thr Uncertain significance Single submitter
- CDC23 p.Leu167Phe Uncertain significance Single submitter
- CDC23 p.Lys230Glu Uncertain significance Single submitter
- CDC23 p.Pro63Leu Uncertain significance Single submitter
- CDC23 p.Pro63Ser Uncertain significance Single submitter
- CDC23 p.Thr582Ile Uncertain significance Single submitter
- CDC23 p.Thr596Met Uncertain significance Single submitter
- CDC23 p.Tyr115Asn Uncertain significance Single submitter
- CDC23 p.Val191Ala Uncertain significance Single submitter
- CDC23 p.Val471Met Uncertain significance Single submitter
All CDC23 variants
Benign 2
- c.1286+10G>A Single submitter
- p.Asp541= Single submitter
Uncertain significance 40
- p.Ala68Asp Single submitter ⚠
- p.Arg424Gln Single submitter ⚠
- p.Arg424Trp Single submitter ⚠
- p.Arg585His Single submitter ⚠
- p.Asn110His Single submitter ⚠
- p.Asn23Tyr Single submitter ⚠
- p.Asn287Ser Single submitter ⚠
- p.Asn581Ser Single submitter ⚠
- p.Cys532Phe Single submitter ⚠
- p.Glu231Asp Single submitter ⚠
- p.Gly108Ser Single submitter ⚠
- p.His162Arg Single submitter ⚠
- p.Ile255Thr Single submitter ⚠
- p.Ile497Thr Single submitter ⚠
- p.Ile503Thr Single submitter ⚠
- p.Leu167Phe Single submitter ⚠
- p.Leu42His Single submitter ⚠
- p.Lys230Glu Single submitter ⚠
- p.Lys492Arg Single submitter ⚠
- p.Pro18Ser Single submitter ⚠
- p.Pro225Ala Single submitter ⚠
- p.Pro570Leu Single submitter ⚠
- p.Pro63Leu Single submitter ⚠
- p.Pro63Ser Single submitter ⚠
- p.Pro66Ser Single submitter ⚠
- p.Pro72Leu Single submitter ⚠
- p.Pro73Ala Single submitter ⚠
- p.Pro73Leu Single submitter ⚠
- p.Ser121Tyr Single submitter ⚠
- p.Ser594Pro Single submitter ⚠
- p.Thr564Ala Single submitter ⚠
- p.Thr582Ile Single submitter ⚠
- p.Thr596Met Single submitter ⚠
- p.Trp203Gly Single submitter ⚠
- p.Tyr115Asn Single submitter ⚠
- p.Tyr115Cys Single submitter ⚠
- p.Val191Ala Single submitter ⚠
- p.Val471Met Single submitter ⚠
- p.Val504Leu Single submitter ⚠
- p.Val96Ile Single submitter ⚠