CDC25A — 48 ClinVar variants
All ClinVar germline CDC25A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 43 flagged for review →
1 Likely pathogenic · 1 Benign · 5 Likely benign · 41 Uncertain significance
Full CDC25A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 43
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors vs ClinVar 1
ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.
-
CDC25A p.Ser88Phe
Likely pathogenic
No assertion criteria
autosomal dominant polycystic liver disease
Predictors lean, ClinVar uncertain 32
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CDC25A p.Ala145Asp Uncertain significance Single submitter
- CDC25A p.Ala145Gly Uncertain significance Single submitter
- CDC25A p.Ala22Val Uncertain significance Single submitter
- CDC25A p.Arg157His Uncertain significance Single submitter
- CDC25A p.Arg175Ser Uncertain significance Single submitter
- CDC25A p.Arg182Leu Uncertain significance Single submitter
- CDC25A p.Arg502Leu Uncertain significance Single submitter
- CDC25A p.Asn226Lys Uncertain significance Single submitter
-
CDC25A p.Asn375Ser
Uncertain significance
Single submitter
autosomal dominant polycystic liver disease
- CDC25A p.Asn44Thr Uncertain significance Single submitter
- CDC25A p.Cys256Trp Uncertain significance Single submitter
- CDC25A p.Glu301Val Uncertain significance Single submitter
- CDC25A p.Glu406Lys Uncertain significance Single submitter
- CDC25A p.Gly90Glu Uncertain significance Single submitter
- CDC25A p.Ile426Val Uncertain significance Single submitter
- CDC25A p.Leu160Arg Uncertain significance Single submitter
- CDC25A p.Leu98Phe Uncertain significance Single submitter
- CDC25A p.Lys457Arg Uncertain significance Single submitter
- CDC25A p.Met294Leu Uncertain significance Single submitter
- CDC25A p.Phe132Cys Uncertain significance Single submitter
- CDC25A p.Pro19Ser Uncertain significance Single submitter
- CDC25A p.Pro20Ser Uncertain significance Single submitter
- CDC25A p.Pro234Ser Uncertain significance Single submitter
- CDC25A p.Pro322Arg Uncertain significance Single submitter
- CDC25A p.Pro7Ser Uncertain significance Single submitter
- CDC25A p.Ser267Thr Uncertain significance Single submitter
- CDC25A p.Ser295Phe Uncertain significance Single submitter
- CDC25A p.Thr202Lys Uncertain significance Single submitter
-
CDC25A p.Thr349Ile
Uncertain significance
Single submitter
autosomal dominant polycystic liver disease
- CDC25A p.Thr420Ala Uncertain significance Single submitter
- CDC25A p.Val246Ile Uncertain significance Single submitter
- CDC25A p.Val27Leu Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- CDC25A p.Arg10His Uncertain significance Single submitter
- CDC25A p.Arg270Gln Uncertain significance Single submitter
- CDC25A p.Arg335Gly Uncertain significance Single submitter
- CDC25A p.Asp223Val Uncertain significance Single submitter
- CDC25A p.Glu392Lys Uncertain significance Single submitter
- CDC25A p.Glu511Gln Uncertain significance Single submitter
- CDC25A p.Glu78Lys Uncertain significance Single submitter
- CDC25A p.Leu312Val Uncertain significance Single submitter
- CDC25A p.Leu318Pro Likely benign Single submitter
- CDC25A p.Ser77Ala Uncertain significance Single submitter
All CDC25A variants
Likely pathogenic 1
- p.Ser88Phe No assertion criteria autosomal dominant polycystic liver disease ⚠
Benign 1
- p.Gln24His Multiple submitters
Likely benign 5
- p.Asn332Ser Single submitter
- p.Leu318Pro Single submitter ⚠
- p.Thr303Ala Single submitter
- p.Val219Met Single submitter
- p.Lys323Arg No assertion criteria autosomal dominant polycystic liver disease
Uncertain significance 41
- p.Ala145Asp Single submitter ⚠
- p.Ala145Gly Single submitter ⚠
- p.Ala22Val Single submitter ⚠
- p.Arg10His Single submitter ⚠
- p.Arg157His Single submitter ⚠
- p.Arg175Ser Single submitter ⚠
- p.Arg182Leu Single submitter ⚠
- p.Arg270Gln Single submitter ⚠
- p.Arg335Gly Single submitter ⚠
- p.Arg502Leu Single submitter ⚠
- p.Asn226Lys Single submitter ⚠
- p.Asn375Ser Single submitter autosomal dominant polycystic liver disease ⚠
- p.Asn44Thr Single submitter ⚠
- p.Asp223Val Single submitter ⚠
- p.Cys256Trp Single submitter ⚠
- p.Glu301Val Single submitter ⚠
- p.Glu392Lys Single submitter ⚠
- p.Glu406Lys Single submitter ⚠
- p.Glu511Gln Single submitter ⚠
- p.Glu78Lys Single submitter ⚠
- p.Gly90Glu Single submitter ⚠
- p.Ile426Val Single submitter ⚠
- p.Leu160Arg Single submitter ⚠
- p.Leu312Val Single submitter ⚠
- p.Leu98Phe Single submitter ⚠
- p.Lys457Arg Single submitter ⚠
- p.Met294Leu Single submitter ⚠
- p.Phe132Cys Single submitter ⚠
- p.Pro19Ser Single submitter ⚠
- p.Pro20Ser Single submitter ⚠
- p.Pro234Ser Single submitter ⚠
- p.Pro322Arg Single submitter ⚠
- p.Pro7Ser Single submitter ⚠
- p.Ser267Thr Single submitter ⚠
- p.Ser295Phe Single submitter ⚠
- p.Ser77Ala Single submitter ⚠
- p.Thr202Lys Single submitter ⚠
- p.Thr349Ile Single submitter autosomal dominant polycystic liver disease ⚠
- p.Thr420Ala Single submitter ⚠
- p.Val246Ile Single submitter ⚠
- p.Val27Leu Single submitter ⚠