CDC25B — 91 ClinVar variants
All ClinVar germline CDC25B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 84 flagged for review →
9 Likely benign · 82 Uncertain significance
Full CDC25B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 84
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 50
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CDC25B p.Ala124Val Uncertain significance Single submitter
- CDC25B p.Ala171Val Uncertain significance Single submitter
- CDC25B p.Ala231Thr Uncertain significance Single submitter
- CDC25B p.Ala23Ser Uncertain significance Single submitter
- CDC25B p.Ala252Asp Uncertain significance Single submitter
- CDC25B p.Ala46Ser Uncertain significance Single submitter
- CDC25B p.Ala48Ser Uncertain significance Single submitter
- CDC25B p.Ala549Asp Uncertain significance Single submitter
- CDC25B p.Ala63Ser Uncertain significance Single submitter
- CDC25B p.Ala63Thr Uncertain significance Single submitter
- CDC25B p.Arg140Pro Uncertain significance Single submitter
- CDC25B p.Arg164Gln Uncertain significance Single submitter
- CDC25B p.Arg241Gln Uncertain significance Single submitter
- CDC25B p.Arg241Trp Uncertain significance Single submitter
- CDC25B p.Arg45Pro Uncertain significance Single submitter
- CDC25B p.Arg461Cys Uncertain significance Single submitter
- CDC25B p.Arg461His Uncertain significance Single submitter
- CDC25B p.Arg493His Uncertain significance Single submitter
- CDC25B p.Arg558Cys Uncertain significance Single submitter
- CDC25B p.Arg568Gln Uncertain significance Single submitter
- CDC25B p.Arg570Gln Uncertain significance Single submitter
- CDC25B p.Arg571Gln Uncertain significance Single submitter
- CDC25B p.Arg92Pro Uncertain significance Single submitter
- CDC25B p.Asp61Glu Uncertain significance Single submitter
- CDC25B p.Gln126Lys Uncertain significance Single submitter
- CDC25B p.Glu142Lys Uncertain significance Single submitter
- CDC25B p.Glu190Asp Uncertain significance Single submitter
- CDC25B p.Gly196Ala Uncertain significance Single submitter
- CDC25B p.Gly254Asp Uncertain significance Single submitter
- CDC25B p.Gly64Ala Uncertain significance Single submitter
- CDC25B p.Ile482Val Uncertain significance Single submitter
- CDC25B p.Leu279Val Uncertain significance Single submitter
- CDC25B p.Leu318Phe Uncertain significance Single submitter
- CDC25B p.Leu62Phe Uncertain significance Single submitter
- CDC25B p.Lys334Arg Uncertain significance Single submitter
- CDC25B p.Met123Val Uncertain significance Single submitter
- CDC25B p.Met420Leu Uncertain significance Single submitter
- CDC25B p.Met59Val Uncertain significance Single submitter
- CDC25B p.Pro205Ser Uncertain significance Single submitter
- CDC25B p.Pro260Ser Uncertain significance Single submitter
- CDC25B p.Pro286Leu Uncertain significance Single submitter
- CDC25B p.Pro471Thr Uncertain significance Single submitter
- CDC25B p.Pro4Ser Uncertain significance Single submitter
- CDC25B p.Ser209Gly Uncertain significance Single submitter
- CDC25B p.Ser375Leu Uncertain significance Single submitter
- CDC25B p.Ser470Arg Uncertain significance Single submitter
- CDC25B p.Thr167Ile Uncertain significance Single submitter
- CDC25B p.Thr56Ala Uncertain significance Single submitter
- CDC25B p.Val354Leu Uncertain significance Single submitter
- CDC25B p.Val354Met Uncertain significance Single submitter
Predictors split 34
The independent predictors disagree with each other — read with care.
- CDC25B p.Ala463Thr Uncertain significance Single submitter
- CDC25B p.Arg148His Uncertain significance Single submitter
- CDC25B p.Arg164Trp Uncertain significance Single submitter
- CDC25B p.Arg175Trp Likely benign Single submitter
- CDC25B p.Arg220Cys Uncertain significance Single submitter
- CDC25B p.Arg255Cys Uncertain significance Single submitter
- CDC25B p.Arg330Trp Uncertain significance Single submitter
- CDC25B p.Arg338Trp Uncertain significance Single submitter
- CDC25B p.Arg369Cys Uncertain significance Single submitter
- CDC25B p.Arg369His Uncertain significance Single submitter
- CDC25B p.Arg504Gly Uncertain significance Single submitter
- CDC25B p.Arg568Trp Uncertain significance Single submitter
- CDC25B p.Arg571Trp Uncertain significance Single submitter
- CDC25B p.Arg84Cys Uncertain significance Single submitter
- CDC25B p.Arg84His Uncertain significance Single submitter
- CDC25B p.Arg93Trp Uncertain significance Single submitter
- CDC25B p.Asp269Glu Uncertain significance Single submitter
- CDC25B p.Asp510Asn Uncertain significance Single submitter
- CDC25B p.Glu96Lys Uncertain significance Single submitter
- CDC25B p.Leu78Phe Uncertain significance Single submitter
- CDC25B p.Pro121His Uncertain significance Single submitter
- CDC25B p.Pro153Thr Uncertain significance Single submitter
- CDC25B p.Pro239Thr Uncertain significance Single submitter
- CDC25B p.Pro345Leu Uncertain significance Single submitter
- CDC25B p.Ser106Tyr Uncertain significance Single submitter
- CDC25B p.Ser229Asn Likely benign Single submitter
- CDC25B p.Ser230Leu Uncertain significance Single submitter
- CDC25B p.Ser238Gly Uncertain significance Single submitter
- CDC25B p.Ser249Arg Uncertain significance Single submitter
- CDC25B p.Ser387Asn Uncertain significance Single submitter
- CDC25B p.Thr419Met Uncertain significance Single submitter
- CDC25B p.Thr69Ile Uncertain significance Single submitter
- CDC25B p.Val162Met Uncertain significance Single submitter
- CDC25B p.Val328Met Uncertain significance Single submitter
All CDC25B variants
Likely benign 9
- p.Arg175Trp Single submitter ⚠
- p.Gly174Ser Single submitter
- p.Gly183Arg Single submitter
- p.His87Arg Single submitter
- p.Met119Val Single submitter
- p.Pro172= Single submitter
- p.Ser229Asn Single submitter ⚠
- p.Thr127= Single submitter
- p.Val310Ile Single submitter
Uncertain significance 82
- p.Ala124Val Single submitter ⚠
- p.Ala171Val Single submitter ⚠
- p.Ala231Thr Single submitter ⚠
- p.Ala23Ser Single submitter ⚠
- p.Ala252Asp Single submitter ⚠
- p.Ala463Thr Single submitter ⚠
- p.Ala46Ser Single submitter ⚠
- p.Ala48Ser Single submitter ⚠
- p.Ala549Asp Single submitter ⚠
- p.Ala63Ser Single submitter ⚠
- p.Ala63Thr Single submitter ⚠
- p.Arg140Pro Single submitter ⚠
- p.Arg148His Single submitter ⚠
- p.Arg164Gln Single submitter ⚠
- p.Arg164Trp Single submitter ⚠
- p.Arg220Cys Single submitter ⚠
- p.Arg241Gln Single submitter ⚠
- p.Arg241Trp Single submitter ⚠
- p.Arg255Cys Single submitter ⚠
- p.Arg330Trp Single submitter ⚠
- p.Arg338Trp Single submitter ⚠
- p.Arg369Cys Single submitter ⚠
- p.Arg369His Single submitter ⚠
- p.Arg45Pro Single submitter ⚠
- p.Arg461Cys Single submitter ⚠
- p.Arg461His Single submitter ⚠
- p.Arg493His Single submitter ⚠
- p.Arg504Gly Single submitter ⚠
- p.Arg558Cys Single submitter ⚠
- p.Arg568Gln Single submitter ⚠
- p.Arg568Trp Single submitter ⚠
- p.Arg570Gln Single submitter ⚠
- p.Arg571Gln Single submitter ⚠
- p.Arg571Trp Single submitter ⚠
- p.Arg84Cys Single submitter ⚠
- p.Arg84His Single submitter ⚠
- p.Arg92Pro Single submitter ⚠
- p.Arg93Trp Single submitter ⚠
- p.Asp269Glu Single submitter ⚠
- p.Asp510Asn Single submitter ⚠
- p.Asp61Glu Single submitter ⚠
- p.Gln126Lys Single submitter ⚠
- p.Glu142Lys Single submitter ⚠
- p.Glu190Asp Single submitter ⚠
- p.Glu96Lys Single submitter ⚠
- p.Gly196Ala Single submitter ⚠
- p.Gly254Asp Single submitter ⚠
- p.Gly64Ala Single submitter ⚠
- p.Ile482Val Single submitter ⚠
- p.Leu279Val Single submitter ⚠
- p.Leu318Phe Single submitter ⚠
- p.Leu62Phe Single submitter ⚠
- p.Leu78Phe Single submitter ⚠
- p.Lys334Arg Single submitter ⚠
- p.Met123Val Single submitter ⚠
- p.Met420Leu Single submitter ⚠
- p.Met59Val Single submitter ⚠
- p.Pro121His Single submitter ⚠
- p.Pro153Thr Single submitter ⚠
- p.Pro205Ser Single submitter ⚠
- p.Pro239Thr Single submitter ⚠
- p.Pro260Ser Single submitter ⚠
- p.Pro286Leu Single submitter ⚠
- p.Pro345Leu Single submitter ⚠
- p.Pro471Thr Single submitter ⚠
- p.Pro4Ser Single submitter ⚠
- p.Ser106Tyr Single submitter ⚠
- p.Ser209Gly Single submitter ⚠
- p.Ser230Leu Single submitter ⚠
- p.Ser238Gly Single submitter ⚠
- p.Ser249Arg Single submitter ⚠
- p.Ser375Leu Single submitter ⚠
- p.Ser387Asn Single submitter ⚠
- p.Ser470Arg Single submitter ⚠
- p.Thr167Ile Single submitter ⚠
- p.Thr419Met Single submitter ⚠
- p.Thr56Ala Single submitter ⚠
- p.Thr69Ile Single submitter ⚠
- p.Val162Met Single submitter ⚠
- p.Val328Met Single submitter ⚠
- p.Val354Leu Single submitter ⚠
- p.Val354Met Single submitter ⚠