CDC25C — 73 ClinVar variants
All ClinVar germline CDC25C variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 70 flagged for review →
3 Likely benign · 70 Uncertain significance
Full CDC25C gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 70
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 48
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CDC25C p.Arg136Cys Uncertain significance Single submitter
- CDC25C p.Arg208Lys Uncertain significance Single submitter
- CDC25C p.Arg331Cys Uncertain significance Single submitter
- CDC25C p.Arg370Gly Uncertain significance Single submitter
- CDC25C p.Arg383Gly Uncertain significance Single submitter
- CDC25C p.Arg392His Uncertain significance Single submitter
- CDC25C p.Asn24Thr Uncertain significance Single submitter
- CDC25C p.Asn278Asp Uncertain significance Single submitter
- CDC25C p.Asn76Lys Uncertain significance Single submitter
- CDC25C p.Asp201Ala Uncertain significance Single submitter
- CDC25C p.Asp36Glu Uncertain significance Single submitter
- CDC25C p.Asp395Asn Uncertain significance Single submitter
- CDC25C p.Asp395Gly Uncertain significance Single submitter
- CDC25C p.Cys128Arg Uncertain significance Single submitter
- CDC25C p.Cys145Tyr Uncertain significance Single submitter
- CDC25C p.Gln116Glu Uncertain significance Single submitter
- CDC25C p.Gln186Pro Uncertain significance Single submitter
- CDC25C p.Gln279His Uncertain significance Single submitter
- CDC25C p.Glu34Gln Uncertain significance Single submitter
- CDC25C p.Glu382Gly Uncertain significance Single submitter
- CDC25C p.Glu422Gly Uncertain significance Single submitter
- CDC25C p.Gly137Cys Uncertain significance Single submitter
- CDC25C p.Gly183Arg Uncertain significance Single submitter
- CDC25C p.Gly414Asp Uncertain significance Single submitter
- CDC25C p.Gly456Arg Uncertain significance Single submitter
- CDC25C p.Gly55Ala Uncertain significance Single submitter
- CDC25C p.Gly66Arg Uncertain significance Single submitter
- CDC25C p.Ile269Val Uncertain significance Single submitter
- CDC25C p.Ile341Asn Uncertain significance Single submitter
- CDC25C p.Ile62Ser Uncertain significance Single submitter
- CDC25C p.Lys178Arg Uncertain significance Single submitter
- CDC25C p.Lys233Arg Uncertain significance Single submitter
- CDC25C p.Lys240Glu Uncertain significance Single submitter
- CDC25C p.Lys441Arg Uncertain significance Single submitter
- CDC25C p.Met435Val Uncertain significance Single submitter
- CDC25C p.Phe325Cys Uncertain significance Single submitter
- CDC25C p.Pro215Leu Uncertain significance Single submitter
- CDC25C p.Pro224Leu Uncertain significance Single submitter
- CDC25C p.Ser102Leu Uncertain significance Single submitter
- CDC25C p.Ser349Asn Uncertain significance Single submitter
- CDC25C p.Ser451Gly Uncertain significance Single submitter
- CDC25C p.Ser61Asn Uncertain significance Single submitter
- CDC25C p.Thr236Ile Uncertain significance Single submitter
- CDC25C p.Thr9Ala Uncertain significance Single submitter
- CDC25C p.Tyr245Cys Uncertain significance Single submitter
- CDC25C p.Tyr406Ser Uncertain significance Single submitter
- CDC25C p.Val363Ile Uncertain significance Single submitter
- CDC25C p.Val374Leu Uncertain significance Single submitter
Predictors split 22
The independent predictors disagree with each other — read with care.
- CDC25C p.Arg213Cys Uncertain significance Single submitter
- CDC25C p.Arg26Met Uncertain significance Single submitter
- CDC25C p.Arg417Gly Uncertain significance Single submitter
- CDC25C p.Arg458Trp Uncertain significance Single submitter
- CDC25C p.Arg461Trp Uncertain significance Single submitter
- CDC25C p.Asn399Ser Uncertain significance Single submitter
- CDC25C p.Asp418Tyr Uncertain significance Single submitter
- CDC25C p.Asp73His Uncertain significance Single submitter
- CDC25C p.Glu323Gly Uncertain significance Single submitter
- CDC25C p.Leu466Pro Uncertain significance Single submitter
- CDC25C p.Lys303Thr Uncertain significance Single submitter
- CDC25C p.Lys452Glu Uncertain significance Single submitter
- CDC25C p.Pro131Leu Uncertain significance Single submitter
- CDC25C p.Pro421Thr Uncertain significance Single submitter
- CDC25C p.Ser15Cys Uncertain significance Single submitter
- CDC25C p.Ser214Phe Uncertain significance Single submitter
- CDC25C p.Ser57Cys Uncertain significance Single submitter
- CDC25C p.Ser75Leu Uncertain significance Single submitter
- CDC25C p.Ser75Trp Uncertain significance Single submitter
- CDC25C p.Tyr326Cys Uncertain significance Single submitter
- CDC25C p.Tyr348His Uncertain significance Single submitter
- CDC25C p.Val295Met Uncertain significance Single submitter
All CDC25C variants
Likely benign 3
- p.Ala291Val Single submitter
- p.Arg136His Single submitter
- p.Thr294= Single submitter
Uncertain significance 70
- p.Arg136Cys Single submitter ⚠
- p.Arg208Lys Single submitter ⚠
- p.Arg213Cys Single submitter ⚠
- p.Arg26Met Single submitter ⚠
- p.Arg331Cys Single submitter ⚠
- p.Arg370Gly Single submitter ⚠
- p.Arg383Gly Single submitter ⚠
- p.Arg392His Single submitter ⚠
- p.Arg417Gly Single submitter ⚠
- p.Arg458Trp Single submitter ⚠
- p.Arg461Trp Single submitter ⚠
- p.Asn24Thr Single submitter ⚠
- p.Asn278Asp Single submitter ⚠
- p.Asn399Ser Single submitter ⚠
- p.Asn76Lys Single submitter ⚠
- p.Asp201Ala Single submitter ⚠
- p.Asp36Glu Single submitter ⚠
- p.Asp395Asn Single submitter ⚠
- p.Asp395Gly Single submitter ⚠
- p.Asp418Tyr Single submitter ⚠
- p.Asp73His Single submitter ⚠
- p.Cys128Arg Single submitter ⚠
- p.Cys145Tyr Single submitter ⚠
- p.Gln116Glu Single submitter ⚠
- p.Gln186Pro Single submitter ⚠
- p.Gln279His Single submitter ⚠
- p.Glu323Gly Single submitter ⚠
- p.Glu34Gln Single submitter ⚠
- p.Glu382Gly Single submitter ⚠
- p.Glu422Gly Single submitter ⚠
- p.Gly137Cys Single submitter ⚠
- p.Gly183Arg Single submitter ⚠
- p.Gly414Asp Single submitter ⚠
- p.Gly456Arg Single submitter ⚠
- p.Gly55Ala Single submitter ⚠
- p.Gly66Arg Single submitter ⚠
- p.Ile269Val Single submitter ⚠
- p.Ile341Asn Single submitter ⚠
- p.Ile62Ser Single submitter ⚠
- p.Leu466Pro Single submitter ⚠
- p.Lys178Arg Single submitter ⚠
- p.Lys233Arg Single submitter ⚠
- p.Lys240Glu Single submitter ⚠
- p.Lys303Thr Single submitter ⚠
- p.Lys441Arg Single submitter ⚠
- p.Lys452Glu Single submitter ⚠
- p.Met435Val Single submitter ⚠
- p.Phe325Cys Single submitter ⚠
- p.Pro131Leu Single submitter ⚠
- p.Pro215Leu Single submitter ⚠
- p.Pro224Leu Single submitter ⚠
- p.Pro421Thr Single submitter ⚠
- p.Ser102Leu Single submitter ⚠
- p.Ser15Cys Single submitter ⚠
- p.Ser214Phe Single submitter ⚠
- p.Ser349Asn Single submitter ⚠
- p.Ser451Gly Single submitter ⚠
- p.Ser57Cys Single submitter ⚠
- p.Ser61Asn Single submitter ⚠
- p.Ser75Leu Single submitter ⚠
- p.Ser75Trp Single submitter ⚠
- p.Thr236Ile Single submitter ⚠
- p.Thr9Ala Single submitter ⚠
- p.Tyr245Cys Single submitter ⚠
- p.Tyr326Cys Single submitter ⚠
- p.Tyr348His Single submitter ⚠
- p.Tyr406Ser Single submitter ⚠
- p.Val295Met Single submitter ⚠
- p.Val363Ile Single submitter ⚠
- p.Val374Leu Single submitter ⚠