CDC34 — 34 ClinVar variants
All ClinVar germline CDC34 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 33 flagged for review →
1 Likely benign · 33 Uncertain significance
Full CDC34 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 33
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 19
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CDC34 p.Ala176Val Uncertain significance Single submitter
- CDC34 p.Ala196Val Uncertain significance Single submitter
- CDC34 p.Ala2Ser Uncertain significance Single submitter
- CDC34 p.Ala44Val Uncertain significance Single submitter
- CDC34 p.Arg3Gln Uncertain significance Single submitter
- CDC34 p.Asp208His Uncertain significance Single submitter
- CDC34 p.Asp226Glu Uncertain significance Single submitter
- CDC34 p.Cys191Tyr Uncertain significance Single submitter
- CDC34 p.Glu189Lys Uncertain significance Single submitter
- CDC34 p.Glu22Lys Uncertain significance Single submitter
- CDC34 p.Gly107Arg Uncertain significance Single submitter
- CDC34 p.Gly214Ser Uncertain significance Single submitter
- CDC34 p.Gly90Glu Uncertain significance Single submitter
- CDC34 p.Phe206Leu Uncertain significance Single submitter
- CDC34 p.Thr233Met Uncertain significance Single submitter
- CDC34 p.Tyr207Asp Uncertain significance Single submitter
- CDC34 p.Tyr68His Uncertain significance Single submitter
- CDC34 p.Val216Met Uncertain significance Single submitter
- CDC34 p.Val6Ala Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- CDC34 p.Arg159Gln Uncertain significance Single submitter
- CDC34 p.Arg61Cys Uncertain significance Single submitter
- CDC34 p.Arg76Gln Uncertain significance Single submitter
- CDC34 p.Asp200Asn Uncertain significance Single submitter
- CDC34 p.Asp208Asn Uncertain significance Single submitter
- CDC34 p.Asp227Asn Uncertain significance Single submitter
- CDC34 p.Glu189Asp Uncertain significance Single submitter
- CDC34 p.Glu212Gln Uncertain significance Single submitter
- CDC34 p.Glu219Lys Uncertain significance Single submitter
- CDC34 p.Glu88Lys Uncertain significance Single submitter
- CDC34 p.Lys150Arg Uncertain significance Single submitter
- CDC34 p.Lys157Glu Uncertain significance Single submitter
- CDC34 p.Pro197Leu Uncertain significance Single submitter
- CDC34 p.Val101Met Uncertain significance Single submitter
All CDC34 variants
Likely benign 1
- p.Ile96= Single submitter
Uncertain significance 33
- p.Ala176Val Single submitter ⚠
- p.Ala196Val Single submitter ⚠
- p.Ala2Ser Single submitter ⚠
- p.Ala44Val Single submitter ⚠
- p.Arg159Gln Single submitter ⚠
- p.Arg3Gln Single submitter ⚠
- p.Arg61Cys Single submitter ⚠
- p.Arg76Gln Single submitter ⚠
- p.Asp200Asn Single submitter ⚠
- p.Asp208Asn Single submitter ⚠
- p.Asp208His Single submitter ⚠
- p.Asp226Glu Single submitter ⚠
- p.Asp227Asn Single submitter ⚠
- p.Cys191Tyr Single submitter ⚠
- p.Glu189Asp Single submitter ⚠
- p.Glu189Lys Single submitter ⚠
- p.Glu212Gln Single submitter ⚠
- p.Glu219Lys Single submitter ⚠
- p.Glu22Lys Single submitter ⚠
- p.Glu88Lys Single submitter ⚠
- p.Gly107Arg Single submitter ⚠
- p.Gly214Ser Single submitter ⚠
- p.Gly90Glu Single submitter ⚠
- p.Lys150Arg Single submitter ⚠
- p.Lys157Glu Single submitter ⚠
- p.Phe206Leu Single submitter ⚠
- p.Pro197Leu Single submitter ⚠
- p.Thr233Met Single submitter ⚠
- p.Tyr207Asp Single submitter ⚠
- p.Tyr68His Single submitter ⚠
- p.Val101Met Single submitter ⚠
- p.Val216Met Single submitter ⚠
- p.Val6Ala Single submitter ⚠