CDC37 — 43 ClinVar variants
All ClinVar germline CDC37 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 41 flagged for review →
3 Benign · 40 Uncertain significance
Full CDC37 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 41
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 21
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CDC37 p.Ala329Ser Uncertain significance Single submitter
- CDC37 p.Ala366Val Uncertain significance Single submitter
- CDC37 p.Ala86Val Uncertain significance Single submitter
- CDC37 p.Arg235Trp Uncertain significance Single submitter
- CDC37 p.Arg264Trp Uncertain significance Single submitter
- CDC37 p.Arg266Cys Uncertain significance Single submitter
- CDC37 p.Arg92His Uncertain significance Single submitter
- CDC37 p.Arg92Leu Uncertain significance Single submitter
- CDC37 p.Asp310Tyr Uncertain significance Single submitter
- CDC37 p.Asp375Asn Uncertain significance Single submitter
- CDC37 p.Glu11Asp Uncertain significance Single submitter
- CDC37 p.Glu185Lys Uncertain significance Single submitter
- CDC37 p.Gly290Ser Uncertain significance Single submitter
- CDC37 p.Ile271Val Uncertain significance Single submitter
- CDC37 p.Lys93Arg Uncertain significance Single submitter
- CDC37 p.Met105Leu Uncertain significance Single submitter
- CDC37 p.Met128Val Uncertain significance Single submitter
- CDC37 p.Pro21Ser Uncertain significance Single submitter
- CDC37 p.Pro359Leu Uncertain significance Single submitter
- CDC37 p.Ser349Asn Uncertain significance Single submitter
- CDC37 p.Val311Met Uncertain significance Single submitter
Predictors split 20
The independent predictors disagree with each other — read with care.
- CDC37 p.Arg166Cys Uncertain significance Single submitter
- CDC37 p.Arg235Gln Uncertain significance Single submitter
- CDC37 p.Arg246His Uncertain significance Single submitter
- CDC37 p.Arg264Gln Uncertain significance Single submitter
- CDC37 p.Arg283His Uncertain significance Single submitter
- CDC37 p.Asp177Asn Uncertain significance Single submitter
- CDC37 p.Gln100His Uncertain significance Single submitter
- CDC37 p.Glu142Lys Uncertain significance Single submitter
- CDC37 p.Glu198Asp Uncertain significance Single submitter
- CDC37 p.Glu281Ala Uncertain significance Single submitter
- CDC37 p.Glu296Lys Uncertain significance Single submitter
- CDC37 p.Glu56Asp Uncertain significance Single submitter
- CDC37 p.Ile214Val Uncertain significance Single submitter
- CDC37 p.Lys132Gln Uncertain significance Single submitter
- CDC37 p.Lys147Asn Uncertain significance Single submitter
- CDC37 p.Ser322Arg Uncertain significance Single submitter
- CDC37 p.Thr136Met Uncertain significance Single submitter
- CDC37 p.Tyr278Cys Uncertain significance Single submitter
- CDC37 p.Val295Ile Benign Single submitter
- CDC37 p.Val295Phe Uncertain significance Single submitter
All CDC37 variants
Benign 3
- p.Phe151= Multiple submitters
- p.Glu299= Single submitter
- p.Val295Ile Single submitter ⚠
Uncertain significance 40
- p.Ala329Ser Single submitter ⚠
- p.Ala366Val Single submitter ⚠
- p.Ala86Val Single submitter ⚠
- p.Arg166Cys Single submitter ⚠
- p.Arg235Gln Single submitter ⚠
- p.Arg235Trp Single submitter ⚠
- p.Arg246His Single submitter ⚠
- p.Arg264Gln Single submitter ⚠
- p.Arg264Trp Single submitter ⚠
- p.Arg266Cys Single submitter ⚠
- p.Arg283His Single submitter ⚠
- p.Arg92His Single submitter ⚠
- p.Arg92Leu Single submitter ⚠
- p.Asp177Asn Single submitter ⚠
- p.Asp310Tyr Single submitter ⚠
- p.Asp375Asn Single submitter ⚠
- p.Gln100His Single submitter ⚠
- p.Glu11Asp Single submitter ⚠
- p.Glu142Lys Single submitter ⚠
- p.Glu185Lys Single submitter ⚠
- p.Glu198Asp Single submitter ⚠
- p.Glu281Ala Single submitter ⚠
- p.Glu296Lys Single submitter ⚠
- p.Glu56Asp Single submitter ⚠
- p.Gly290Ser Single submitter ⚠
- p.Ile214Val Single submitter ⚠
- p.Ile271Val Single submitter ⚠
- p.Lys132Gln Single submitter ⚠
- p.Lys147Asn Single submitter ⚠
- p.Lys93Arg Single submitter ⚠
- p.Met105Leu Single submitter ⚠
- p.Met128Val Single submitter ⚠
- p.Pro21Ser Single submitter ⚠
- p.Pro359Leu Single submitter ⚠
- p.Ser322Arg Single submitter ⚠
- p.Ser349Asn Single submitter ⚠
- p.Thr136Met Single submitter ⚠
- p.Tyr278Cys Single submitter ⚠
- p.Val295Phe Single submitter ⚠
- p.Val311Met Single submitter ⚠