CDC37L1 — 47 ClinVar variants
All ClinVar germline CDC37L1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 42 flagged for review →
3 Likely benign · 44 Uncertain significance
Full CDC37L1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 42
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 39
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CDC37L1 p.Ala316Val Uncertain significance Single submitter
- CDC37L1 p.Arg104Thr Uncertain significance Single submitter
- CDC37L1 p.Arg111Gln Uncertain significance Single submitter
- CDC37L1 p.Arg15Pro Uncertain significance Single submitter
- CDC37L1 p.Asn286Asp Uncertain significance Single submitter
- CDC37L1 p.Asp151His Uncertain significance Single submitter
- CDC37L1 p.Asp153Gly Uncertain significance Single submitter
- CDC37L1 p.Cys233Tyr Uncertain significance Single submitter
- CDC37L1 p.Cys35Tyr Uncertain significance Single submitter
- CDC37L1 p.Gln164Arg Uncertain significance Single submitter
- CDC37L1 p.Gln275Leu Uncertain significance Single submitter
- CDC37L1 p.Gln91Glu Uncertain significance Single submitter
- CDC37L1 p.Glu109Val Uncertain significance Single submitter
- CDC37L1 p.Glu251Lys Uncertain significance Single submitter
- CDC37L1 p.Glu264Gln Uncertain significance Single submitter
- CDC37L1 p.Glu327Asp Uncertain significance Single submitter
- CDC37L1 p.Gly294Arg Uncertain significance Single submitter
- CDC37L1 p.Ile198Thr Uncertain significance Single submitter
- CDC37L1 p.Ile296Val Uncertain significance Single submitter
- CDC37L1 p.Leu13Val Uncertain significance Single submitter
- CDC37L1 p.Leu243Phe Uncertain significance Single submitter
- CDC37L1 p.Lys138Arg Uncertain significance Single submitter
- CDC37L1 p.Lys332Arg Uncertain significance Single submitter
- CDC37L1 p.Met159Val Uncertain significance Single submitter
- CDC37L1 p.Met282Ile Uncertain significance Single submitter
- CDC37L1 p.Met282Val Uncertain significance Single submitter
- CDC37L1 p.Pro281Arg Uncertain significance Single submitter
- CDC37L1 p.Pro30Arg Uncertain significance Single submitter
- CDC37L1 p.Pro39Ser Uncertain significance Single submitter
- CDC37L1 p.Pro39Thr Uncertain significance Single submitter
- CDC37L1 p.Pro8Leu Uncertain significance Single submitter
- CDC37L1 p.Ser24Asn Uncertain significance Single submitter
- CDC37L1 p.Ser278Thr Uncertain significance Single submitter
- CDC37L1 p.Ser319Arg Uncertain significance Single submitter
- CDC37L1 p.Ser31Thr Uncertain significance Single submitter
- CDC37L1 p.Thr128Ser Uncertain significance Single submitter
- CDC37L1 p.Tyr308Cys Uncertain significance Single submitter
- CDC37L1 p.Val284Phe Uncertain significance Single submitter
- CDC37L1 p.Val288Ile Uncertain significance Single submitter
Predictors split 3
The independent predictors disagree with each other — read with care.
All CDC37L1 variants
Likely benign 3
- p.Asp177= Single submitter
- p.Ser314Asn Single submitter
- p.Ser31Gly Single submitter
Uncertain significance 44
- p.Ala316Val Single submitter ⚠
- p.Arg104Thr Single submitter ⚠
- p.Arg111Gln Single submitter ⚠
- p.Arg15Pro Single submitter ⚠
- p.Arg180Ser Single submitter ⚠
- p.Asn286Asp Single submitter ⚠
- p.Asp151His Single submitter ⚠
- p.Asp153Gly Single submitter ⚠
- p.Cys233Tyr Single submitter ⚠
- p.Cys35Tyr Single submitter ⚠
- p.Gln164Arg Single submitter ⚠
- p.Gln275Leu Single submitter ⚠
- p.Gln91Glu Single submitter ⚠
- p.Glu109Val Single submitter ⚠
- p.Glu156fs Single submitter
- p.Glu251Lys Single submitter ⚠
- p.Glu264Gln Single submitter ⚠
- p.Glu300Ter Single submitter
- p.Glu327Asp Single submitter ⚠
- p.Gly294Arg Single submitter ⚠
- p.Ile166Met Single submitter ⚠
- p.Ile198Thr Single submitter ⚠
- p.Ile296Val Single submitter ⚠
- p.Leu13Val Single submitter ⚠
- p.Leu188Ile Single submitter ⚠
- p.Leu243Phe Single submitter ⚠
- p.Lys138Arg Single submitter ⚠
- p.Lys332Arg Single submitter ⚠
- p.Met159Val Single submitter ⚠
- p.Met282Ile Single submitter ⚠
- p.Met282Val Single submitter ⚠
- p.Pro281Arg Single submitter ⚠
- p.Pro30Arg Single submitter ⚠
- p.Pro39Ser Single submitter ⚠
- p.Pro39Thr Single submitter ⚠
- p.Pro8Leu Single submitter ⚠
- p.Ser24Asn Single submitter ⚠
- p.Ser278Thr Single submitter ⚠
- p.Ser319Arg Single submitter ⚠
- p.Ser31Thr Single submitter ⚠
- p.Thr128Ser Single submitter ⚠
- p.Tyr308Cys Single submitter ⚠
- p.Val284Phe Single submitter ⚠
- p.Val288Ile Single submitter ⚠