CDC42BPG — 295 ClinVar variants

All ClinVar germline CDC42BPG variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 273 flagged for review →

4 Benign · 22 Likely benign · 269 Uncertain significance

Full CDC42BPG gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 273

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 134

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 139

The independent predictors disagree with each other — read with care.

All CDC42BPG variants

Benign 4

p.Ile77= Multiple submitters
p.Lys467Asn Multiple submitters
p.Pro1257= Multiple submitters
p.Glu170= Single submitter

Likely benign 22

p.Ala1318Val Single submitter
p.Ala1325Thr Single submitter
p.Ala792Thr Single submitter
p.Ala861Val Single submitter
p.Arg1120His Single submitter
p.Arg417Gln Single submitter
p.Arg444Gln Single submitter
p.Arg488Gln Single submitter
p.Arg493Gln Single submitter ⚠
p.Arg496Gln Single submitter
p.Arg541Gln Single submitter
p.Arg566Gln Single submitter
p.Arg643Gln Single submitter
p.Arg647Gln Single submitter
p.Arg935His Single submitter
p.Asn1122= Single submitter
p.Glu521Lys Single submitter ⚠
p.Met1320Thr Single submitter
p.Pro1463Arg Single submitter ⚠
p.Thr569Met Single submitter ⚠
p.Thr673= Single submitter
p.His438Gln No assertion criteria EBV-positive nodal T- and NK-cell lymphoma

Uncertain significance 269

p.Ala1013Val Single submitter ⚠
p.Ala1036Val Single submitter ⚠
p.Ala1071Val Single submitter ⚠
p.Ala1098Thr Single submitter ⚠
p.Ala1242Val Single submitter ⚠
p.Ala1243Thr Single submitter ⚠
p.Ala1247Gly Single submitter ⚠
p.Ala1255Pro Single submitter ⚠
p.Ala1262Thr Single submitter ⚠
p.Ala1458Ser Single submitter ⚠
p.Ala172Thr Single submitter ⚠
p.Ala266Thr Single submitter ⚠
p.Ala308Thr Single submitter ⚠
p.Ala346Val Single submitter ⚠
p.Ala413Thr Single submitter ⚠
p.Ala414Val Single submitter ⚠
p.Ala499Thr Single submitter ⚠
p.Ala503Thr Single submitter ⚠
p.Ala585Pro Single submitter ⚠
p.Ala591Asp Single submitter ⚠
p.Ala615Thr Single submitter ⚠
p.Ala634Val Single submitter ⚠
p.Ala682Thr Single submitter ⚠
p.Ala780Thr Single submitter ⚠
p.Ala7Ser Single submitter ⚠
p.Ala7Thr Single submitter ⚠
p.Ala835Asp Single submitter ⚠
p.Arg1029Lys Single submitter ⚠
p.Arg1056Cys Single submitter ⚠
p.Arg1056His Single submitter ⚠
p.Arg1066Gln Single submitter ⚠
p.Arg1066Trp Single submitter ⚠
p.Arg1072Gln Single submitter ⚠
p.Arg1072Trp Single submitter ⚠
p.Arg1076Leu Single submitter ⚠
p.Arg1076Trp Single submitter ⚠
p.Arg1105Gln Single submitter ⚠
p.Arg1131Gln Single submitter ⚠
p.Arg1132Cys Single submitter ⚠
p.Arg1156Cys Single submitter ⚠
p.Arg1177Gly Single submitter ⚠
p.Arg117Leu Single submitter ⚠
p.Arg117Pro Single submitter ⚠
p.Arg1191Gly Single submitter ⚠
p.Arg120Gln Single submitter ⚠
p.Arg120Trp Single submitter ⚠
p.Arg1217Cys Single submitter ⚠
p.Arg1217His Single submitter ⚠
p.Arg1218Cys Single submitter ⚠
p.Arg1218His Single submitter ⚠
p.Arg129His Single submitter ⚠
p.Arg1306Cys Single submitter ⚠
p.Arg1379Gly Single submitter ⚠
p.Arg1399His Single submitter ⚠
p.Arg1423Cys Single submitter ⚠
p.Arg1455Trp Single submitter ⚠
p.Arg1470Gln Single submitter ⚠
p.Arg1488Trp Single submitter ⚠
p.Arg1489Gly Single submitter ⚠
p.Arg1507Lys Single submitter ⚠
p.Arg1537Trp Single submitter ⚠
p.Arg210Cys Single submitter ⚠
p.Arg313Cys Single submitter ⚠
p.Arg318Cys Single submitter ⚠
p.Arg318Leu Single submitter ⚠
p.Arg332Gln Single submitter ⚠
p.Arg417Trp Single submitter ⚠
p.Arg431Gly Single submitter ⚠
p.Arg444Trp Single submitter ⚠
p.Arg450Trp Single submitter ⚠
p.Arg496Trp Single submitter ⚠
p.Arg566Leu Single submitter ⚠
p.Arg578Cys Single submitter ⚠
p.Arg578Gly Single submitter ⚠
p.Arg578His Single submitter ⚠
p.Arg617Gln Single submitter ⚠
p.Arg643Trp Single submitter ⚠
p.Arg651Gln Single submitter ⚠
p.Arg65His Single submitter ⚠
p.Arg670Gln Single submitter ⚠
p.Arg671Trp Single submitter ⚠
p.Arg723Gln Single submitter ⚠
p.Arg723Trp Single submitter ⚠
p.Arg799Gln Single submitter ⚠
p.Arg799Trp Single submitter ⚠
p.Arg850Cys Single submitter ⚠
p.Arg853Cys Single submitter ⚠
p.Arg860Ile Single submitter ⚠
p.Arg882Cys Single submitter ⚠
p.Arg884Gln Single submitter ⚠
p.Arg904Cys Single submitter ⚠
p.Arg935Cys Single submitter ⚠
p.Arg963Trp Single submitter ⚠
p.Arg964Gln Single submitter ⚠
p.Arg987Thr Single submitter ⚠
p.Asn1380Asp Single submitter ⚠
p.Asn1396Ser Single submitter ⚠
p.Asn1442Lys Single submitter ⚠
p.Asn1442Ser Single submitter ⚠
p.Asn200Ser Single submitter ⚠
p.Asn689Ser Single submitter ⚠
p.Asp1015Glu Single submitter ⚠
p.Asp1389Asn Single submitter ⚠
p.Asp1395His Single submitter ⚠
p.Asp199Asn Single submitter ⚠
p.Asp204Gly Single submitter ⚠
p.Asp341Asn Single submitter ⚠
p.Asp474His Single submitter ⚠
p.Asp484Asn Single submitter ⚠
p.Asp683Tyr Single submitter ⚠
p.Asp70Tyr Single submitter ⚠
p.Asp910His Single submitter ⚠
p.Cys1149Tyr Single submitter ⚠
p.Cys1179Tyr Single submitter ⚠
p.Cys217Phe Single submitter ⚠
p.Cys421Ser Single submitter ⚠
p.Cys916Tyr Single submitter ⚠
p.Gln1103His Single submitter ⚠
p.Gln139Arg Single submitter ⚠
p.Gln1522Glu Single submitter ⚠
p.Gln434Glu Single submitter ⚠
p.Gln489Arg Single submitter ⚠
p.Gln577Pro Single submitter ⚠
p.Gln765Arg Single submitter ⚠
p.Gln789Arg Single submitter ⚠
p.Gln923Glu Single submitter ⚠
p.Glu1111Lys Single submitter ⚠
p.Glu1485Lys Single submitter ⚠
p.Glu1516Lys Single submitter ⚠
p.Glu164Lys Single submitter ⚠
p.Glu170Asp Single submitter ⚠
p.Glu320Lys Single submitter ⚠
p.Glu425Asp Single submitter ⚠
p.Glu500Lys Single submitter ⚠
p.Glu533Gln Single submitter ⚠
p.Glu63Gly Single submitter ⚠
p.Glu640Gly Single submitter ⚠
p.Glu672Ala Single submitter ⚠
p.Glu752Ala Single submitter ⚠
p.Glu781Lys Single submitter ⚠
p.Glu796Lys Single submitter ⚠
p.Glu834Lys Single submitter ⚠
p.Glu943Lys Single submitter ⚠
p.Gly1062Cys Single submitter ⚠
p.Gly1185Glu Single submitter ⚠
p.Gly1209Val Single submitter ⚠
p.Gly1211Ser Single submitter ⚠
p.Gly1245Asp Single submitter ⚠
p.Gly1263Ser Single submitter ⚠
p.Gly1274Arg Single submitter ⚠
p.Gly1281Arg Single submitter ⚠
p.Gly1363Asp Single submitter ⚠
p.Gly1450Ala Single submitter ⚠
p.Gly1454Trp Single submitter ⚠
p.Gly1457Asp Single submitter ⚠
p.Gly249Asp Single submitter ⚠
p.Gly388Ser Single submitter ⚠
p.Gly504Glu Single submitter ⚠
p.Gly596Arg Single submitter ⚠
p.Gly630Arg Single submitter ⚠
p.Gly668Ser Single submitter ⚠
p.Gly802Arg Single submitter ⚠
p.Gly855Glu Single submitter ⚠
p.Gly901Ser Single submitter ⚠
p.Gly913Ser Single submitter ⚠
p.His1311Tyr Single submitter ⚠
p.His1445Arg Single submitter ⚠
p.His33Pro Single submitter ⚠
p.His438Tyr Single submitter ⚠
p.His589Tyr Single submitter ⚠
p.His838Arg Single submitter ⚠
p.His879Arg Single submitter ⚠
p.His879Gln Single submitter ⚠
p.Ile1173Thr Single submitter ⚠
p.Leu1035Pro Single submitter ⚠
p.Leu1047Arg Single submitter ⚠
p.Leu1145Pro Single submitter ⚠
p.Leu1252Phe Single submitter ⚠
p.Leu1353Phe Single submitter ⚠
p.Leu1367Phe Single submitter ⚠
p.Leu1393Phe Single submitter ⚠
p.Leu156Val Single submitter ⚠
p.Leu211Met Single submitter ⚠
p.Leu28Val Single submitter ⚠
p.Leu470Phe Single submitter ⚠
p.Leu526Ile Single submitter ⚠
p.Leu844Gln Single submitter ⚠
p.Leu881Pro Single submitter ⚠
p.Leu8Pro Single submitter ⚠
p.Leu933His Single submitter ⚠
p.Leu933Val Single submitter ⚠
p.Lys1506Arg Single submitter ⚠
p.Lys250Asn Single submitter ⚠
p.Met1426Ile Single submitter ⚠
p.Met246Val Single submitter ⚠
p.Met737Thr Single submitter ⚠
p.Met854Ile Single submitter ⚠
p.Met854Val Single submitter ⚠
p.Phe116Cys Single submitter ⚠
p.Phe1366Val Single submitter ⚠
p.Phe1410Val Single submitter ⚠
p.Phe1483Cys Single submitter ⚠
p.Phe331Val Single submitter ⚠
p.Phe953Leu Single submitter ⚠
p.Pro1004Leu Single submitter ⚠
p.Pro1038Ala Single submitter ⚠
p.Pro1090Leu Single submitter ⚠
p.Pro1193Leu Single submitter ⚠
p.Pro1210Leu Single submitter ⚠
p.Pro1361Arg Single submitter ⚠
p.Pro1430Arg Single submitter ⚠
p.Pro1504Ala Single submitter ⚠
p.Pro1527Arg Single submitter ⚠
p.Pro302Ser Single submitter ⚠
p.Pro380Leu Single submitter ⚠
p.Pro56Leu Single submitter ⚠
p.Pro724Thr Single submitter ⚠
p.Pro808Arg Single submitter ⚠
p.Pro808Leu Single submitter ⚠
p.Pro829Ala Single submitter ⚠
p.Pro842Thr Single submitter ⚠
p.Pro846Leu Single submitter ⚠
p.Pro889Leu Single submitter ⚠
p.Pro928Leu Single submitter ⚠
p.Pro990Leu Single submitter ⚠
p.Ser1272Phe Single submitter ⚠
p.Ser1286Asn Single submitter ⚠
p.Ser1364Tyr Single submitter ⚠
p.Ser1406Asn Single submitter ⚠
p.Ser1462Thr Single submitter ⚠
p.Ser185Leu Single submitter ⚠
p.Ser307Asn Single submitter ⚠
p.Ser407Ile Single submitter ⚠
p.Ser538Asn Single submitter ⚠
p.Ser582Leu Single submitter ⚠
p.Ser646Ile Single submitter ⚠
p.Ser820Asn Single submitter ⚠
p.Ser851Arg Single submitter ⚠
p.Ser878Ala Single submitter ⚠
p.Ser897Leu Single submitter ⚠
p.Thr1041Met Single submitter ⚠
p.Thr1441Ser Single submitter ⚠
p.Thr473Ala Single submitter ⚠
p.Thr673Met Single submitter ⚠
p.Thr703Ile Single submitter ⚠
p.Thr719Met Single submitter ⚠
p.Thr880Met Single submitter ⚠
p.Thr918Ala Single submitter ⚠
p.Trp1215Arg Single submitter ⚠
p.Tyr1085Cys Single submitter ⚠
p.Tyr1206Cys Single submitter ⚠
p.Tyr150Cys Single submitter ⚠
p.Tyr277Cys Single submitter ⚠
p.Val1078Met Single submitter ⚠
p.Val1155Met Single submitter ⚠
p.Val1168Ile Single submitter ⚠
p.Val1199Ile Single submitter ⚠
p.Val1265Leu Single submitter ⚠
p.Val131Leu Single submitter ⚠
p.Val1351Met Single submitter ⚠
p.Val1414Leu Single submitter ⚠
p.Val1432Glu Single submitter ⚠
p.Val1471Ala Single submitter ⚠
p.Val264Ile Single submitter ⚠
p.Val304Met Single submitter ⚠
p.Val58Ile Single submitter ⚠
p.Val87Met Single submitter ⚠
p.Val929Met Single submitter ⚠
p.Val969Met Single submitter ⚠