CDC42SE1 — 12 ClinVar variants
All ClinVar germline CDC42SE1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 12 flagged for review →
12 Uncertain significance
Full CDC42SE1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 12
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 7
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CDC42SE1 p.Arg24Trp Uncertain significance Single submitter
- CDC42SE1 p.Arg27Trp Uncertain significance Single submitter
- CDC42SE1 p.Arg69Gln Uncertain significance Single submitter
- CDC42SE1 p.Asp26Asn Uncertain significance Single submitter
- CDC42SE1 p.Cys11Tyr Uncertain significance Single submitter
- CDC42SE1 p.Glu46Asp Uncertain significance Single submitter
- CDC42SE1 p.Met55Thr Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All CDC42SE1 variants
Uncertain significance 12
- p.Arg24Trp Single submitter ⚠
- p.Arg27Trp Single submitter ⚠
- p.Arg69Gln Single submitter ⚠
- p.Asp26Asn Single submitter ⚠
- p.Cys11Tyr Single submitter ⚠
- p.Gln17Arg Single submitter ⚠
- p.Glu14Lys Single submitter ⚠
- p.Glu46Asp Single submitter ⚠
- p.Met55Thr Single submitter ⚠
- p.Pro18Leu Single submitter ⚠
- p.Ser76Phe Single submitter ⚠
- p.Thr56Arg Single submitter ⚠